Neil Paterson


Neil Paterson has joined I03 as a Beamline Scientist following 3 years as a PDRA on I24. Prior to joining Diamond at the end of 2012, Neil spent 5 years at the University of Auckland studying Gram-positive bacterial pili and their post-translational modifications using X-ray crystallography and mass spectrometry.

Tel: +44 (0) 1235 778929

Key Research Area

  • Experimental phasing
  • Beamline developments

Current Research Interests


Who: Dr Miriam Sharpe (University of Otago, NZ) and Associate Professor Peter Metcalf (University of Auckland, NZ).

Title: Bioluminescent microcrystals from the Firefly squid

Summary: Watasenia scintillans, firefly squid or 'hotaru-ika', is a deep water resident of the waters around Japan which rises to shallow waters in the Spring to spawn and die. The squid is noticeable for the intense bioluminescent light it produces from sets of three, luciferase-containing, light organs located at the tips of two tentacles. Recent research has shown the luciferase in these light organs takes the form of numerous microcrystals of between two and six microns in length. We aim to characterise these microcrystals using the facilities at I24.

This project is supported by a grant from The Royal Society of New Zealand Marsden Fund.


  • Aller, P., Sanchez-Weatherby, J., Foadi, J., Winter, G., Lobley, C.M.C., Axford, D., Ashton, A., Bellini, D., Brandao-Neto, L., Culurgioni, S., Douangamath, A., Duman, R., Evans, G., Fisher, S., Flaig, R., Hall, D.R., Lukacik, P., Mazzorana, M., McAuley, K.E., Mykhaylyk, V., Owen, R.L., Paterson, N.G., Romano, P., Sandy, J., Sorenson, T., von Delft, F., Wagner, A., Warren, A., Williams, M., Stuart, D.I. & Walsh, M.A. Application of in-situ diffraction in high-throughput structure determination platforms. Methods Mol. Biol. 1261, 233-253. (2015)
  • Paterson, N.G. & Baker, E.N. Three-dimensional Structures of Pilin Subunits and their Role in Gram-positive Pilus Assembly and Stability. In Bacterial Pili: Structure, Synthesis and Role in Disease. (eds. Barocchi, M. & Telford, J.L.), CABI. 112-124. (2014)
  • Paterson, N.G., Kang, H.J. & Baker, E.N. Intramolecular isopeptide bonds: novel post-translational modifications in bacterial pili and cell-surface adhesins. In Biomolecular Forms and Functions: A Celebration of 50 years of the Ramachandran Map. (eds. Manju Bansal & N. Srinivasan), IISc Press/World Scientific. 417-427. (2013)


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