Samuel is a Postdoctoral Research Associate working on both VMXm and HeXI. He completed his PhD in Molecular and Cell Biology at the University of Leicester in 2024, under the supervision of Professor Peter Moody. His research area is examining the complementarity between X-ray and electron diffraction instruments.
Email: [email protected]As new techniques are developed, the smallest crystal dimension amenable to X-ray diffraction is decreasing, whilst the maximum dimension available to electron diffraction increases. Therefore, overlap exists between these techniques. Being based at both the micro/nanofocus X-ray beamline, VMXm and the MeV electron diffraction instrument, HeXI, I am interested in exploring what information can be determined from samples prepared for MX or ED (3DED/ microED), and where the similarities and differences lie. Radiation damage caused by X-ray sources is widely studied and largely predictable as a function of dose and sample composition. Due to the inherent differences in the radiation source, I am also interested to study radiation damage with electron diffraction.
Foster, S. P., Warren, A. J., Siebert, C. A., Basran, J. & Moody, P. C. E. (2026). It started off as a Cys, how did it end up like this? Identifying the extent of unmodelled oxidatively modified cysteines within the Protein Data Bank. Acta Cryst. D82.
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