eBIC
PDRA at the electron Bio-Imaging Centre (eBIC)
Gangshun joined eBIC in May 2024.
Email: [email protected]Gangshun Yi
Gangshun earned his Ph.D. degree from the University of Oxford in 2023 and joined eBIC Diamond Light Source in May 2024. He is interested in developing novel methods for structure determination of small proteins based on the utilization of engineered dimeric nanobody, named Di-Gluebodies, which is covalently-rigidified, modular protein assemblies enable simultaneous determination of high-resolution, low-size, cryo- EM structures. Gangshun also works on tumor-suppressor let-7 pre-microRNAs regulation by determination the structures of uridylyltransferases TUT7 and TUT4.
Gangshun Yi†, Dimitrios Mamalis†, Mingda Ye†, Loic Carrique, Michael Fairhead, Huanyu Li, Katharina L. Duerr, Peijun Zhang, David B. Sauer, Frank von Delft, Benjamin G. Davis, Robert J. C. Gilbert. (2024) Di-Gluebodies as covalently-rigidified, modular protein assemblies enable simultaneous determination of high-resolution, low-size, cryo-EM structures. bioRxiv, 2024.6.13
Gang-Shun Yi, Mingda Ye, Loic Carrique, Afaf El-Sagheer, Tom Brown, Chris J. Norbury, Peijun Zhang, Robert J. C. Gilbert. (2024) Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs. Nature Structure & Molecular Biology, doi.org/10.1038/s41594-024-01357-9
Wang Weiwei†,Gang-Shun Yi†, Huan Zhou†, Feng Yu, Jia-Nan Chen, Feng-Ping Wang, Xiang Xiao, Jian-Hua He, Xi- Peng Liu. Structural basis for DNA 3´-end resection by RecJ2. Journal of Biological Chemistry, Joint First Authors.
Gang-Shun Yi, Wei-Wei Wang, Wei-Guo Cao, Feng-Ping Wang, Xi-Peng Liu. (2017) Sulfolobus acidocaldarius UDG Can Remove dU from the RNA Backbone: Insight into the Specific Recognition of Uracil Linked with Deoxyribose. GENES 2017.1.18
Gang-Shun Yi, Yang Song, Wei-Wei Wang, Jia-Nan Chen, Wei Deng, Wei-guo Cao, Feng-Ping Wang, Xiang Xiao, Xi-Peng Liu. (2017) Two Archaeal RecJ Nucleases from Methanocaldococcus jannaschii Show Reverse Hydrolysis Polarity: Implication to Their Unique Function in Archaea. GENES 2017.8.24
Min-Jun Li,† Gang-Shun Yi,† Feng Yu, Huan Zhou, Jia-Nan Chen, Chun-Yan Xu, Feng-Ping Wang, Xiang Xiao, Jian-Hua He, Xi-Peng Liu. (2017) The crystal structure of Pyrococcus furiosus RecJ implicates it as an ancestor of eukaryotic Cdc45. Nucleic Acids Research 2017.10.10, Joint First Authors.
