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  1. Diamond Light Source
  2. News & Literature
  3. Annual Review
  4. Diamond Annual Review 2019
  5. Science Group Updates
  6. Biological Cryo-Imaging Group

Biological Cryo-Imaging Group

  • Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist

    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist Jun 1, 2018

    To design such small molecules, a detailed map of the interactions between GLP-1 and its receptor was needed.

  • Structural insights into the mechanism of bacterial ABC transporters

    Structural insights into the mechanism of bacterial ABC transporters Jun 1, 2018

    Bacteria utilise ATP-binding cassette (ABC) transporters to import nutrients and detoxify themselves. These transporters have been shown to exist ...

  • Structure of the surface layer surrounding Caulobacter crescentus bacteria

    Structure of the surface layer surrounding Caulobacter crescentus bacteria Jun 1, 2018

    Many types of single-celled microorganisms such as bacteria are covered with a protective outer layer of proteins known as the S-layer.

  • How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint.

    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint. Jun 1, 2018

    In all cells derived from animals, plants, fungi and protozoa a single protein called UGGT acts as a quality control checkpoint that inspects ...

  • Insights into the mechanism of colistin resistance from crystal structures of MCR-1

    Insights into the mechanism of colistin resistance from crystal structures of MCR-1 Jun 1, 2018

    Gram-negative bacteria that are extensively resistant to multiple antibiotics are an ever-increasing global threat. Colistin is an antibiotic used ...

  • How human endoglin captures its ligand BMP9

    How human endoglin captures its ligand BMP9 Jun 1, 2018

    Endoglin (ENG)/CD105 is a mammalian glycoprotein that is found in the membranes of cells that line blood vessels. It is essential for healthy ...

Martin Walsh, Deputy Director of Life Sciences

The Biological Cryo-Imaging Group was established a little over a year ago and brings together dedicated facilities for X-ray, light and electron microscopy at Diamond. The bending magnet B24 is the source of X-rays for the full field cryo-transmission X-ray microscope dedicated to biological X-ray imaging. The beamline has also established a cryo-super resolution fluorescence microscopy facility, which is a joint venture between Diamond and the University of Oxford. Exploiting electrons for imaging, the electron BioImaging Centre (eBIC) is the national centre for cryo-Electron Microscopy (cryo-EM) in the UK and provides a range of capabilities and supporting facilities for cryo-EM. The first year of the Biological Cryo-Imaging Group at Diamond has been a busy one, with both B24 and eBIC developing and expanding their capabilities. This has meant installation, commissioning of new instrumentation, and a major focus on recruitment. Read more  ...

  • Unveiling RNA polymerase III transcription initiation with cryo-EM

    Unveiling RNA polymerase III transcription initiation with cryo-EM Jul 26, 2019

    RNA polymerase (Pol) III is a major determinant of lifespan in eukaryotes (organisms whose cells have a nucleus enclosed within membranes, unlike ...

  • Insight into work of molecular machines supporting genome stability

    Insight into work of molecular machines supporting genome stability Jul 23, 2019

    The work recently published in the journal Science by a team of scientists from Imperial College London featured the structure of the ...

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