Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy B23 Contact
Beamline Phone Number:
+44 (0) 1235 778889
Principal Beamline Scientist:
Giuliano Siligardi
Tel: +44 (0) 1235 778425
E-mail: [email protected]
Science Group Leader
Robert Rambo
Email: [email protected]
Tel: +44 (0)1235 56 7675
B23 Circular Dichroism
Status: Operational
Beamsize: 0.5mm² to 2mm x 4mm
Detector: PMT
Wavelength: 125 - 650 nm
Energy: 2 - 10 eV
Detector: PMT
Wavelength: 125 - 650 nm
Energy: 2 - 10 eV
User Publications
These papers are all based at least in part on data gathered on beamline B23. If you have published a paper based on data from B23 which doesn't appear here, please send a reference (ideally including a DOI) to us.
30 items found for 2018 [total: 374]
Characterisation of sensor kinase by CD spectroscopy: golden rules and tips Biochemical Society Transactions, 3 Dec 2018 DOI: 10.1042/BST20180222
Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism Lab On A Chip, 15 Nov 2018 DOI: 10.1039/C8LC00757H
Journal Paper B23-Circular Dichroism
The role of serum amyloid P in amyloidosis Sept 2018
Thesis B23-Circular Dichroism
High yielding synthesis of chiral donor-acceptor catenanes The Journal Of Organic Chemistry, Aug 2018 DOI: 10.1021/acs.joc.8b01629
Journal Paper B23-Circular Dichroism
Recent developments in nucleobase cation symporter-1 (NCS1) family transport proteins from bacteria, archaea, fungi and plants Journal Of Biosciences, 101 Jul 2018 DOI: 10.1007/s12038-018-9780-3
Journal Paper B23-Circular Dichroism
UV-denaturation assay to assess protein photostability and ligand-binding interactions using the high photon flux of Diamond B23 beamline for SRCD Molecules, 23 Jul 2018 DOI: 10.3390/molecules23081906
Biophysical & crystallographic studies of DNA i-motifs June 2018
Thesis B23-Circular Dichroism I02-Macromolecular Crystallography
Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression Cellular & Molecular Immunology, 368 June 2018 DOI: 10.1038/s41423-018-0053-8
Journal Paper B23-Circular Dichroism
Non-aqueous homogenous biocatalytic conversion of polysaccharides in ionic liquids using chemically modified glucosidase Nature Chemistry, 311 June 2018 DOI: 10.1038/s41557-018-0088-6
Structural and dynamic characterization of the Golgi Reassembly and Stacking Protein (GRASP) in solution June 2018
Thesis B23-Circular Dichroism
Enhancing enzyme activity in ionic solvents June 2018
Science Highlight B23-Circular Dichroism I22-Small angle scattering & Diffraction
Rational design of multi-functional gold nanoparticles with controlled biomolecule adsorption: a multi-method approach for in-depth characterization Nanoscale, 124 May 2018 DOI: 10.1039/C8NR00973B
Insights into the origin of distinct medin fibril morphologies induced by incubation conditions and seeding International Journal Of Molecular Sciences, 19 May 2018 DOI: 10.3390/ijms19051357
Self-assembled porphyrazine-nucleoside on DNA templates: highly fluorescent chromophore arrays and sizing forensic tandem repeat sequences European Journal Of Organic Chemistry, May 2018 DOI: 10.1002/ejoc.201800683
Site-specific glycations of apolipoprotein A-I lead to differentiated functional effects on lipid-binding and on glucose metabolism Biochimica Et Biophysica Acta (bba) - Molecular Basis Of Disease, May 2018 DOI: 10.1016/j.bbadis.2018.05.014
Journal Paper B23-Circular Dichroism
Characterisation of the enterococcal sensor kinase VanSA and its ligand binding properties May 2018
Thesis B23-Circular Dichroism
Spectroscopy data of ceftriaxone-lysozyme interaction and computational studies Data In Brief, Apr 2018 DOI: 10.1016/j.dib.2018.04.079
Modular assembly of proteins on nanoparticles Nature Communications, 9 Apr 2018 DOI: 10.1038/s41467-018-03931-4
Circular dichroism studies of low molecular weight hydrogelators: The use of SRCD and addressing practical issues Chirality, 15 Apr 2018 DOI: 10.1002/chir.22850
Journal Paper B23-Circular Dichroism
The war on leukaemia Apr 2018
Science Highlight B23-Circular Dichroism
Chaperone-like effect of ceftriaxone on HEWL aggregation: A spectroscopic and computational study Biochimica Et Biophysica Acta (bba) - General Subjects, Mar 2018 DOI: 10.1016/j.bbagen.2018.02.014
Journal Paper B23-Circular Dichroism
Discovery and characterization of ZUFSP/ZUP1, a distinct deubiquitinase class important for genome stability Molecular Cell, Mar 2018 DOI: 10.1016/j.molcel.2018.02.023
To boil an egg: substrate binding affects critical stability in thermal unfolding of proteins The Journal Of Physical Chemistry B, Feb 2018 DOI: 10.1021/acs.jpcb.7b10643
Journal Paper B23-Circular Dichroism
Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter Scientific Reports, 8 Feb 2018 DOI: 10.1038/s41598-018-21740-z
The conformation and aggregation of proline-rich surfactant-like peptides The Journal Of Physical Chemistry B, Feb 2018 DOI: 10.1021/acs.jpcb.7b11463
Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates Nanoscale, 25 Feb 2018 DOI: 10.1039/C7NR09436A
High mobility group box 1 (HMGB1) acts as an "alarmin" to promote acute myeloid leukaemia progression Oncoimmunology, 2 Feb 2018 DOI: 10.1080/2162402X.2018.1438109
With help from a few friends Feb 2018
Science Highlight B23-Circular Dichroism
Peptide 'bullets' as new antibiotics Feb 2018
Science Highlight B23-Circular Dichroism
The stoichiometric interaction of the Hsp90-Sgt1-Rar1 complex by CD and SRCD spectroscopy Frontiers In Molecular Biosciences, 4 Jan 2018 DOI: 10.3389/fmolb.2017.00095
- Giuliano Siligardi, Charlotte S. Hughes, Rohanah Hussain, "Characterisation of sensor kinase by CD spectroscopy: golden rules and tips", Biochemical Society Transactions, 3 (2018), DOI: 10.1042/BST20180222
- Christian Bortolini, Tadas Kartanas, Davor Copic, Itzel Condado Morales, Yuewen Zhang, Pavan K. Challa, Quentin Peter, Tamas Javorfi, Rohanah Hussain, Mingdong Dong, Giuliano Siligardi, Tuomas P. J. Knowles, Jerome Charmet, "Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism", Lab On A Chip, 15 (2018), DOI: 10.1039/C8LC00757H
- [Thesis] Rebecca Coker, "The role of serum amyloid P in amyloidosis" (2018)
- Mehrafarin Eilbigi Dehkordi, Vijay Luxami, G. Dan Pantos, "High yielding synthesis of chiral donor-acceptor catenanes", The Journal Of Organic Chemistry (2018), DOI: 10.1021/acs.joc.8b01629
- Simon G. Patching, "Recent developments in nucleobase cation symporter-1 (NCS1) family transport proteins from bacteria, archaea, fungi and plants", Journal Of Biosciences, 101 (2018), DOI: 10.1007/s12038-018-9780-3
- Rohanah Hussain, Edoardo Longo, Giuliano Siligardi, "UV-denaturation assay to assess protein photostability and ligand-binding interactions using the high photon flux of Diamond B23 beamline for SRCD", Molecules, 23 (2018), DOI: 10.3390/molecules23081906
- [Thesis] S. P. Gurung, "Biophysical & crystallographic studies of DNA i-motifs" (2018)
- Svetlana S. Sakhnevych, Inna M. Yasinska, Alison M. Bratt, Ouafa Benlaouer, Isabel Gonçalves Silva, Rohanah Hussain, Giuliano Siligardi, Walter Fiedler, Jasmin Wellbrock, Bernhard F. Gibbs, Yuri A. Ushkaryov, Vadim V. Sumbayev, "Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression", Cellular & Molecular Immunology, 368 (2018), DOI: 10.1038/s41423-018-0053-8
- Alex P. S. Brogan, Liem Bui-Le, Jason P. Hallett, "Non-aqueous homogenous biocatalytic conversion of polysaccharides in ionic liquids using chemically modified glucosidase", Nature Chemistry, 311 (2018), DOI: 10.1038/s41557-018-0088-6
- [Thesis] Luis Felipe Santos Mendes, "Structural and dynamic characterization of the Golgi Reassembly and Stacking Protein (GRASP) in solution" (2018)
- [Science Highlight] Diamond Light Source, "Enhancing enzyme activity in ionic solvents" (2018)
- Isaac Ojea-Jimenez, Robin Capomaccio, Inês Osório, Dora Mehn, Giacomo Ceccone, Rohanah Hussain, Giuliano Siligardi, Pascal Colpo, François Rossi, Douglas Gilliland, Luigi Calzolai, "Rational design of multi-functional gold nanoparticles with controlled biomolecule adsorption: a multi-method approach for in-depth characterization", Nanoscale, 124 (2018), DOI: 10.1039/C8NR00973B
- Hannah A. Davies, Chiu Fan Lee, Leanne Miller, Lu-Ning Liu, Jillian Madine, "Insights into the origin of distinct medin fibril morphologies induced by incubation conditions and seeding", International Journal Of Molecular Sciences, 19 (2018), DOI: 10.3390/ijms19051357
- Mariia V. Ishutkina, Alice R. Berry, Rohanah Hussain, Olga G. Khelevina, Giuliano Siligardi, Eugen Stulz, "Self-assembled porphyrazine-nucleoside on DNA templates: highly fluorescent chromophore arrays and sizing forensic tandem repeat sequences", European Journal Of Organic Chemistry (2018), DOI: 10.1002/ejoc.201800683
- Joan Domingo-Espin, Oktawia Nilsson, Katja Bernfur, Rita Del Giudice, Jens O. Lagerstedt, "Site-specific glycations of apolipoprotein A-I lead to differentiated functional effects on lipid-binding and on glucose metabolism", Biochimica Et Biophysica Acta (bba) - Molecular Basis Of Disease (2018), DOI: 10.1016/j.bbadis.2018.05.014
- [Thesis] Charlotte Sarah Hughes, "Characterisation of the enterococcal sensor kinase VanSA and its ligand binding properties" (2018)
- Paolo Ruzza, Rosa Maria Vitale, Rohanah Hussain, Alessia Montini, Claudia Honisch, Alice Pozzebon, Charlotte S. Hughes, Barbara Biondi, Pietro Amodeo, Gianpietro Sechi, Giuliano Siligardi, "Spectroscopy data of ceftriaxone-lysozyme interaction and computational studies", Data In Brief (2018), DOI: 10.1016/j.dib.2018.04.079
- Wenwei Ma, Angela Saccardo, Danilo Roccatano, Dorothy Aboagye-Mensah, Mohammad Alkaseem, Matthew Jewkes, Francesca Di Nezza, Mark Baron, Mikhail Soloviev, Enrico Ferrari, "Modular assembly of proteins on nanoparticles", Nature Communications, 9, 1489 (2018), DOI: 10.1038/s41467-018-03931-4
- Efstratios D. Sitsanidis, Carmen C. Piras, Bruce D. Alexander, Giuliano Siligardi, Tamas Javorfi, Andrew J. Hall, Alison A. Edwards, "Circular dichroism studies of low molecular weight hydrogelators: The use of SRCD and addressing practical issues", Chirality, 15 (2018), DOI: 10.1002/chir.22850
- [Science Highlight] Diamond Light Source, "The war on leukaemia" (2018)
- Paolo Ruzza, Rosa Maria Vitale, Rohanah Hussain, Alessia Montini, Claudia Honisch, Alice Pozzebon, Charlotte S. Hughes, Barbara Biondi, Pietro Amodeo, Gianpietro Sechi, Giuliano Siligardi, "Chaperone-like effect of ceftriaxone on HEWL aggregation: A spectroscopic and computational study", Biochimica Et Biophysica Acta (bba) - General Subjects (2018), DOI: 10.1016/j.bbagen.2018.02.014
- Dominika Kwasna, Syed Arif Abdul Rehman, Jayaprakash Natarajan, Stephen Matthews, Ross Madden, Virginia De Cesare, Simone Weidlich, Satpal Virdee, Ivan Ahel, Ian Gibbs-Seymour, Yogesh Kulathu, "Discovery and characterization of ZUFSP/ZUP1, a distinct deubiquitinase class important for genome stability", Molecular Cell (2018), DOI: 10.1016/j.molcel.2018.02.023
- Rohanah Hussain, Charlotte S. Hughes, Tamas Javorfi, Giuliano Siligardi, Paul Williams, Boyan B. Bonev, "To boil an egg: substrate binding affects critical stability in thermal unfolding of proteins", The Journal Of Physical Chemistry B (2018), DOI: 10.1021/acs.jpcb.7b10643
- Raghavendra Sashi Krishna Nagampalli, José Edwin Neciosup Quesñay, Douglas Adamoski, Zeyaul Islam, James Birch, Heitor Gobbi Sebinelli, Richard Marcel Bruno Moreira Girard, Carolline Fernanda Rodrigues Ascenção, Angela Maria Fala, Bianca Alves Pauletti, Sílvio Roberto Consonni, Juliana Ferreira De Oliveira, Amanda Cristina Teixeira Silva, Kleber Gomes Franchini, Adriana Franco Paes Leme, Ariel Mariano Silber, Pietro Ciancaglini, Isabel Moraes, Sandra Martha Gomes Dias, Andre Luis Berteli Ambrosio, "Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter", Scientific Reports, 8 (2018), DOI: 10.1038/s41598-018-21740-z
- Ian W. Hamley, Valeria Castelletto, Ashkan Dehsorkhi, Juan Torras, Carlos Aleman, Irina Portnaya, Dganit Danino, "The conformation and aggregation of proline-rich surfactant-like peptides", The Journal Of Physical Chemistry B (2018), DOI: 10.1021/acs.jpcb.7b11463
- Inna M. Yasinska, Giacomo Ceccone, Isaac Ojea-Jimenez, Jessica Ponti, Rohanah Hussain, Giuliano Siligardi, Steffen M. Berger, Elizaveta Fasler-Kan, Marco Bardelli, Luca Varani, Walter Fiedler, Jasmin Wellbrock, Ulrike Raap, Bernhard F. Gibbs, Luigi Calzolai, Vadim V. Sumbayev, "Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates", Nanoscale, 25 (2018), DOI: 10.1039/C7NR09436A
- Inna M. Yasinska, Isabel Gonçalves Silva, Svetlana S. Sakhnevych, Laura Ruegg, Rohanah Hussain, Giuliano Siligardi, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Ulrike Raap, Steffen Berger, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev, "High mobility group box 1 (HMGB1) acts as an "alarmin" to promote acute myeloid leukaemia progression", Oncoimmunology, 2, 0 - 0 (2018), DOI: 10.1080/2162402X.2018.1438109
- [Science Highlight] Diamond Light Source, "With help from a few friends" (2018)
- [Science Highlight] Diamond Light Source, "Peptide 'bullets' as new antibiotics" (2018)
- Giuliano Siligardi, Minghao Zhang, Chrisostomos Prodromou, "The stoichiometric interaction of the Hsp90-Sgt1-Rar1 complex by CD and SRCD spectroscopy", Frontiers In Molecular Biosciences, 4 (2018), DOI: 10.3389/fmolb.2017.00095
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