Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy B23 Contact
Beamline Phone Number:
+44 (0) 1235 778889
Principal Beamline Scientist:
Giuliano Siligardi
Tel: +44 (0) 1235 778425
E-mail: [email protected]
Science Group Leader
Robert Rambo
Email: [email protected]
Tel: +44 (0)1235 56 7675
B23 Circular Dichroism
Status: Operational
Beamsize: 0.5mm² to 2mm x 4mm
Detector: PMT
Wavelength: 125 - 650 nm
Energy: 2 - 10 eV
Detector: PMT
Wavelength: 125 - 650 nm
Energy: 2 - 10 eV
User Publications
These papers are all based at least in part on data gathered on beamline B23. If you have published a paper based on data from B23 which doesn't appear here, please send a reference (ideally including a DOI) to us.
26 items found for 2016 [total: 374]
Heparin and methionine oxidation promote the formation of apolipoprotein A-I amyloid comprising α-helical and β-sheet structures. Biochemistry, Dec 2016 DOI: 10.1021/acs.biochem.6b01120
Journal Paper B23-Circular Dichroism
Gold nanoparticles increases UV and thermal stability of human serum albumin Biointerphases, 11 Dec 2016 DOI: 10.1116/1.4972113
High-throughput SRCD using multi-well plates and its applications Scientific Reports, 6 Dec 2016 DOI: 10.1038/srep38028
Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study Organic & Biomolecular Chemistry, Nov 2016 DOI: 10.1039/C6OB01954D
Autonomously folded α-helical lockers promote RNAi* Scientific Reports, 6 Oct 2016 DOI: 10.1038/srep35012
Molecular level characterisation of apolipoprotein A-I aggregation leading to fibrils comprising of both α-helical and β-sheet structures Oct 2016
Thesis B23-Circular Dichroism
Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism Oct 2016
Conference Paper B23-Circular Dichroism
Structural study of of a semiconducting polymer F8BT via Fibre Diffraction Oct 2016
Thesis B23-Circular Dichroism
Body-centred cubic packing of spheres – the ultimate thermotropic assembly mode for highly divergent dendrons Nanoscale Horizons, 2 Sept 2016 DOI: 10.1039/C6NH00155F
A de novo virus-like topology for synthetic virions Journal Of The American Chemical Society, Sept 2016 DOI: 10.1021/jacs.6b05751
Spectroscopy reveals that ethyl esters interact with proteins in wine Food Chemistry, Sept 2016 DOI: 10.1016/j.foodchem.2016.08.133
Journal Paper B23-Circular Dichroism
LOW MOLECULAR WEIGHT GELATORS: SYNTHESIS AND SELF-ASSEMBLY OF SUGAR AMPHIPHILES Sept 2016
Thesis B23-Circular Dichroism
Structural and functional basis for lipid synergy on the activity of the antibacterial peptide ABC transporter McjD Journal Of Biological Chemistry, Aug 2016 DOI: 10.1074/jbc.M116.732107
Characterisation of conformational and ligand binding properties of membrane proteins using Synchrotron Radiation Circular Dichroism (SRCD) Aug 2016 DOI: 10.1007/978-3-319-35072-1_4
Proteins in white wines: their interaction with tannins and aroma compounds Aug 2016
Thesis B23-Circular Dichroism
Raman optical activity of biomolecules: From simple models to complex systems Aug 2016
Thesis B23-Circular Dichroism open access
Making gold metamaterials with a twist Aug 2016
Diamond Annual Review Highlight B23-Circular Dichroism I16-Materials and Magnetism I22-Small angle scattering & Diffraction
Genetic analysis reveals a hierarchy of interactions between polycystin-encoding genes and genes controlling cilia function during left-right determination Plos Genetics, 12 June 2016 DOI: 10.1371/journal.pgen.1006070
Selective uptake and refolding of globular proteins in coacervate microdroplets Langmuir, 32 (23) June 2016 DOI: 10.1021/acs.langmuir.6b01271
Journal Paper B23-Circular Dichroism
Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions Biochemical Society Transactions, 44 June 2016 DOI: 10.1042/BST20160023
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity Journal Of Clinical Investigation, 126 May 2016 DOI: 10.1172/JCI85679
Journal Paper B23-Circular Dichroism I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation Biochimica Et Biophysica Acta (bba) - General Subjects, May 2016 DOI: 10.1016/j.bbagen.2016.04.021
Unpicking nanoparticle-protein structures Apr 2016
Science Highlight B23-Circular Dichroism
Ca-dependent folding of human calumenin Plos One, 11 Mar 2016 DOI: 10.1371/journal.pone.0151547
Journal Paper B21-High Throughput SAXS B23-Circular Dichroism I22-Small angle scattering & Diffraction open access
Solubilizing and stabilizing proteins in anhydrous ionic liquids through formation of protein–polymer surfactant nanoconstructs Journal Of The American Chemical Society, Mar 2016 DOI: 10.1021/jacs.5b13425
Synchrotron radiation circular dichroism (SRCD) spectroscopy investigations of the structure and orientation of membrane proteins in oriented lipid bilayers Biophysical Journal, 110 (3) Feb 2016 DOI: 10.1016/j.bpj.2015.11.1064
Journal Paper B23-Circular Dichroism
- David Townsend, Eleri Hughes, Rohanah Hussain, Giuliano Siligardi, Sara J. Baldock, Jillian Madine, David A. Middleton, "Heparin and methionine oxidation promote the formation of apolipoprotein A-I amyloid comprising α-helical and β-sheet structures.", Biochemistry (2016), DOI: 10.1021/acs.biochem.6b01120
- Robin Capomaccio, Inês Osório, Isaac Ojea-Jimenez, Giacomo Ceccone, Pascal Colpo, Douglas Gilliland, Rohanah Hussain, Giuliano Siligardi, Francois Rossi, Sylvie Ricard-Blum, Luigi Calzolai, "Gold nanoparticles increases UV and thermal stability of human serum albumin", Biointerphases, 11 (2016), DOI: 10.1116/1.4972113
- Rohanah Hussain, Tamas Javorfi, Timothy R. Rudd, Giuliano Siligardi, "High-throughput SRCD using multi-well plates and its applications", Scientific Reports, 6 (2016), DOI: 10.1038/srep38028
- E. De Santis, A. A. Edwards, B. D. Alexander, S. J. Holder, A.-S. Biesse-Martin, B. V. Nielsen, D. Mistry, L. Waters, G. Siligardi, R. Hussain, S. Faure, C. Taillefumier, "Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study", Organic & Biomolecular Chemistry (2016), DOI: 10.1039/C6OB01954D
- Christian P. E. Guyader, Baptiste Lamarre, Emiliana De Santis, James E. Noble, Nigel K. Slater, Maxim G. Ryadnov, "Autonomously folded α-helical lockers promote RNAi*", Scientific Reports, 6 (2016), DOI: 10.1038/srep35012
- [Thesis] David Townsend, "Molecular level characterisation of apolipoprotein A-I aggregation leading to fibrils comprising of both α-helical and β-sheet structures" (2016)
- [Conference Paper] Jerome Charmet, Christian Bortolini, Davor Copic, Itzel Condado Morales, Yuewen Zhang, Tamas Javorfi, Rohanah Hussain, Giuliano Siligardi, Tuomas Knowles, "Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism" (2016)
- [Thesis] Yan Hao, "Structural study of of a semiconducting polymer F8BT via Fibre Diffraction" (2016)
- Xiaohong Yao, Liliana Cseh, Xiangbing Zeng, Min Xue, Yongsong Liu, Goran Ungar, "Body-centred cubic packing of spheres – the ultimate thermotropic assembly mode for highly divergent dendrons", Nanoscale Horizons, 2, 43 - 49 (2016), DOI: 10.1039/C6NH00155F
- James Noble, Emiliana De Santis, Jascindra Ravi, Baptiste Lamarre, Valeria Castelletto, Judith Mantell, Santanu Ray, Maxim G. Ryadnov, "A de novo virus-like topology for synthetic virions", Journal Of The American Chemical Society (2016), DOI: 10.1021/jacs.6b05751
- Mattia Di Gaspero, Paolo Ruzza, Rohanah Hussain, Simone Vincenzi, Barbara Biondi, Diana Gazzola, Giuliano Siligardi, Andrea Curioni, "Spectroscopy reveals that ethyl esters interact with proteins in wine", Food Chemistry (2016), DOI: 10.1016/j.foodchem.2016.08.133
- [Thesis] Carmen Piras, "LOW MOLECULAR WEIGHT GELATORS: SYNTHESIS AND SELF-ASSEMBLY OF SUGAR AMPHIPHILES" (2016)
- Shahid Mehmood, Valentina Corradi, Hassan Choudhury, Rohanah Hussain, Patrick Becker, Danny Axford, Severine Zirah, Sylvie Rebuffat, D. Peter Tieleman, Carol V. Robinson, Konstantinos Beis, "Structural and functional basis for lipid synergy on the activity of the antibacterial peptide ABC transporter McjD", Journal Of Biological Chemistry (2016), DOI: 10.1074/jbc.M116.732107
- [Book Chapter] Rohanah Hussain, Giuliano Siligardi, "Characterisation of conformational and ligand binding properties of membrane proteins using Synchrotron Radiation Circular Dichroism (SRCD)" (2016), DOI: 10.1007/978-3-319-35072-1_4
- [Thesis] Mattia Di Gaspero, "Proteins in white wines: their interaction with tannins and aroma compounds" (2016)
- [Thesis] Marketa Pazderkova, "Raman optical activity of biomolecules: From simple models to complex systems" (2016)
- [Diamond Annual Review Highlight] Diamond Light Source, "Making gold metamaterials with a twist" (2016)
- Daniel T. Grimes, Jennifer L. Keynton, Maria Teresa Buenavista, Xingjian Jin, Saloni H. Patel, Shinohara Kyosuke, Jennifer Vibert, Debbie J. Williams, Hiroshi Hamada, Rohanah Hussain, Surya M. Nauli, Dominic P. Norris, "Genetic analysis reveals a hierarchy of interactions between polycystin-encoding genes and genes controlling cilia function during left-right determination", Plos Genetics, 12 (2016), DOI: 10.1371/journal.pgen.1006070
- Nicolas Martin, Mei Li, Stephen Mann, "Selective uptake and refolding of globular proteins in coacervate microdroplets", Langmuir, 32 (23), 5881–5889 (2016), DOI: 10.1021/acs.langmuir.6b01271
- R. Hussain, S. E. Harding, C. S. Hughes, P. Ma, S. G. Patching, S. Edara, G. Siligardi, P. J. F. Henderson, M. K. Phillips-Jones, "Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions", Biochemical Society Transactions, 44, 810 - 823 (2016), DOI: 10.1042/BST20160023
- David Cole, Anna Bulek, Garry Dolton, Andrea J. Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John Miles, Mark Peakman, Linda Wooldridge, Pierre Rizkallah, Andrew K. Sewell, "Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity", Journal Of Clinical Investigation, 126, 2191 - 2204 (2016), DOI: 10.1172/JCI85679
- Paolo Ruzza, Rosa Maria Vitale, Rohanah Hussain, Barbara Biondi, Pietro Amodeo, Gianpietro Sechi, Giuliano Siligardi, "Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation", Biochimica Et Biophysica Acta (bba) - General Subjects (2016), DOI: 10.1016/j.bbagen.2016.04.021
- [Science Highlight] Diamond Light Source, "Unpicking nanoparticle-protein structures" (2016)
- Marco Mazzorana, Rohanah Hussain, Thomas Sorensen, "Ca-dependent folding of human calumenin", Plos One, 11 (2016), DOI: 10.1371/journal.pone.0151547
- Alex P. S. Brogan, Jason P. Hallett, "Solubilizing and stabilizing proteins in anhydrous ionic liquids through formation of protein–polymer surfactant nanoconstructs", Journal Of The American Chemical Society (2016), DOI: 10.1021/jacs.5b13425
- Luke S. Evans, Rohanah Hussain, Giuliano Siligardi, Phil Williamson, "Synchrotron radiation circular dichroism (SRCD) spectroscopy investigations of the structure and orientation of membrane proteins in oriented lipid bilayers", Biophysical Journal, 110 (3), 191a (2016), DOI: 10.1016/j.bpj.2015.11.1064
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