Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy B23 Contact
Beamline Phone Number:
+44 (0) 1235 778889
Principal Beamline Scientist:
Giuliano Siligardi
Tel: +44 (0) 1235 778425
E-mail: [email protected]
Science Group Leader
Robert Rambo
Email: [email protected]
Tel: +44 (0)1235 56 7675
B23 Circular Dichroism
Status: Operational
Beamsize: 0.5mm² to 2mm x 4mm
Detector: PMT
Wavelength: 125 - 650 nm
Energy: 2 - 10 eV
Detector: PMT
Wavelength: 125 - 650 nm
Energy: 2 - 10 eV
User Publications
These papers are all based at least in part on data gathered on beamline B23. If you have published a paper based on data from B23 which doesn't appear here, please send a reference (ideally including a DOI) to us.
20 items found for 2014 [total: 374]
Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism Analytical Methods, Dec 2014 DOI: 10.1039/C4AY02618G
Journal Paper B23-Circular Dichroism
A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide Nature Structural & Molecular Biology, Dec 2014 DOI: 10.1038/nsmb.2935
Journal Paper B23-Circular Dichroism I04-1-Macromolecular Crystallography (fixed wavelength) open access
Scientists gain first glimpse of one of nature's measuring 'rulers' Dec 2014
Science Highlight B23-Circular Dichroism I04-Macromolecular Crystallography
Dynamic mirror-symmetry breaking in bicontinuous cubic phases Angewandte Chemie International Edition, 53 (48) Nov 2014 DOI: 10.1002/anie.201406907
Journal Paper B23-Circular Dichroism I16-Materials and Magnetism I22-Small angle scattering & Diffraction open access
Combined use of capillary electrophoresis and X-ray crystallography in fragment-based drug discovery Nov 2014
Thesis B23-Circular Dichroism
Enzyme activity in liquid lipase melts as a step towards solvent-free biology at 150°C Nature Communications, 5 Oct 2014 DOI: 10.1038/ncomms6058
Self-organization of glucose oxidase-polymer surfactant nanoconstructs in solvent-free soft solids and liquids The Journal Of Physical Chemistry B, 118 (39) Oct 2014 DOI: 10.1021/jp507566u
Journal Paper B23-Circular Dichroism
Heparin derivatives for the targeting of multiple activities in the inflammatory response Carbohydrate Polymers, 117 Oct 2014 DOI: 10.1016/j.carbpol.2014.09.079
Journal Paper B23-Circular Dichroism
Structural studies of Chlamydophila pneumoniae major outer membrane protein (MOMP) and MOMP-derived peptides : candidate vaccine targets for human inflammatory diseases Oct 2014
Thesis B23-Circular Dichroism
Glycosaminoglycans in Autosomal genetic disorders: investigation on multiple hereditary exostoses and cystic fibrosis Sept 2014
Thesis B23-Circular Dichroism
The effect of palmitoylation on the conformation and physical stability of a model peptide hormone International Journal Of Pharmaceutics, 472 Sept 2014 DOI: 10.1016/j.ijpharm.2014.06.008
Journal Paper B23-Circular Dichroism
Electronic circular dichroism of the chiral rigid tricyclic dilactam with nonplanar tertiary amide groups The Journal Of Physical Chemistry B, 118 (38) Sept 2014 DOI: 10.1021/jp5063463
Journal Paper B23-Circular Dichroism
Development of techniques for the analysis of protein: glycosaminoglycan interactions in solution Sept 2014
Thesis B23-Circular Dichroism
Electric charge against antimicrobial resistance Jul 2014
Science Highlight B23-Circular Dichroism
TROSY NMR with a 52 kDa sugar transport protein and the binding of a small-molecule inhibitor Molecular Membrane Biology, 31 (4) June 2014 DOI: 10.3109/09687688.2014.911980
Journal Paper B23-Circular Dichroism
Interactions of the Glial Fibrillary Acidic Protein with ceftriaxone revealed through SRCD May 2014
Poster B23-Circular Dichroism
Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life Proceedings Of The National Academy Of Sciences, 111 Mar 2014 DOI: 10.1073/pnas.1317317111
Influence of elastase on alanine-rich peptide hydrogels Biomaterials Science, Jan 2014 DOI: 10.1039/c4bm00001c
Ligand- and drug-binding studies of membrane proteins revealed through circular dichroism spectroscopy Biochimica Et Biophysica Acta (bba) - Biomembranes, 1838 (1) Jan 2014 DOI: 10.1016/j.bbamem.2013.06.019
Journal Paper B23-Circular Dichroism
Finding the key to combating bacterial resistance to a common antiseptic Jan 2014
Science Highlight B23-Circular Dichroism
- Ashley J. Hughes, Timothy R. Rudd, Gareth S. A. Wright, David Garth Fernig, Giuliano Siligardi, Edwin Yates, "Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism", Analytical Methods (2014), DOI: 10.1039/C4AY02618G
- Gregor Hagelueken, Bradley R Clarke, Hexian Huang, Anne Tuukkanen, Iulia Danciu, Dmitri I Svergun, Rohanah Hussain, Huanting Liu, Chris Whitfield, James Naismith, "A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide", Nature Structural & Molecular Biology (2014), DOI: 10.1038/nsmb.2935
- [Science Highlight] Diamond Light Source, "Scientists gain first glimpse of one of nature's measuring 'rulers'" (2014)
- Christian Dressel, Feng Liu, Marko Prehm, Xiangbing Zeng, Goran Ungar, Carsten Tschierske, "Dynamic mirror-symmetry breaking in bicontinuous cubic phases", Angewandte Chemie International Edition, 53 (48), 13115 - 13120 (2014), DOI: 10.1002/anie.201406907
- [Thesis] Wenjie Chen, "Combined use of capillary electrophoresis and X-ray crystallography in fragment-based drug discovery" (2014)
- Alex P. S. Brogan, Kamendra P. Sharma, Adam W. Perriman, Stephen Mann, "Enzyme activity in liquid lipase melts as a step towards solvent-free biology at 150°C", Nature Communications, 5 (2014), DOI: 10.1038/ncomms6058
- Kamendra Sharma, Yixiong Zhang, Michael R. Thomas, Alex Brogan, Adam Perriman, Stephen Mann, "Self-organization of glucose oxidase-polymer surfactant nanoconstructs in solvent-free soft solids and liquids", The Journal Of Physical Chemistry B, 118 (39), 11573 - 11580 (2014), DOI: 10.1021/jp507566u
- Noemi Veraldi, Ashley J. Hughes, Timothy R. Rudd, Huw B. Thomas, Steven W. Edwards, Lynsay Hadfield, Mark A. Skidmore, Giuliano Siligardi, Cesare Cosentino, Janis K. Shute, Annamaria Naggi, Edwin A. Yates, "Heparin derivatives for the targeting of multiple activities in the inflammatory response", Carbohydrate Polymers, 117, 400 - 407 (2014), DOI: 10.1016/j.carbpol.2014.09.079
- [Thesis] Frank Atanu, "Structural studies of Chlamydophila pneumoniae major outer membrane protein (MOMP) and MOMP-derived peptides : candidate vaccine targets for human inflammatory diseases" (2014)
- [Thesis] Noemi Veraldi, "Glycosaminoglycans in Autosomal genetic disorders: investigation on multiple hereditary exostoses and cystic fibrosis" (2014)
- Edoardo Longo, Emiliana De Santis, Rohanah Hussain, Chris Van Der Walle, Jose Casas-Finet, Shahid Uddin, Ana Dos Santos, Giuliano Siligardi, "The effect of palmitoylation on the conformation and physical stability of a model peptide hormone", International Journal Of Pharmaceutics, 472, 156 - 164 (2014), DOI: 10.1016/j.ijpharm.2014.06.008
- Marketa Pazderkova, Vaclav Profant, Beata Seidlerova, Helena Dlouha, Jana Hodaèová, Tamas Javorfi, Giuliano Siligardi, Vladimír Baumruk, Lucie Bednarova, Petr Malon, "Electronic circular dichroism of the chiral rigid tricyclic dilactam with nonplanar tertiary amide groups", The Journal Of Physical Chemistry B, 118 (38), 11100 - 11108 (2014), DOI: 10.1021/jp5063463
- [Thesis] Ashley Hughes, "Development of techniques for the analysis of protein: glycosaminoglycan interactions in solution" (2014)
- [Science Highlight] Diamond Light Source, "Electric charge against antimicrobial resistance" (2014)
- Arnout P. Kalverda, James Gowdy, Gary S. Thompson, Steve W. Homans, Peter Henderson, Simon G. Patching, "TROSY NMR with a 52 kDa sugar transport protein and the binding of a small-molecule inhibitor", Molecular Membrane Biology, 31 (4), 131 - 140 (2014), DOI: 10.3109/09687688.2014.911980
- [Poster] Paolo Ruzza, Giuliano Siligardi, Rohanah Hussain, Barbara Biondi, Andrea Calderan, Gian Pietro Sechi, "Interactions of the Glial Fibrillary Acidic Protein with ceftriaxone revealed through SRCD" (2014)
- James A. Austin, Gareth S. A. Wright, Seiji Watanabe, J. Günter Grossmann, Svetlana V. Antonyuk, Koji Yamanaka, S. Samar Hasnain, "Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life", Proceedings Of The National Academy Of Sciences, 111, 4309 - 4314 (2014), DOI: 10.1073/pnas.1317317111
- V. Castelletto, R. J. Gouveia, C. J. Connon, I. W. Hamley, J. Seitsonen, J. Ruokolainen, E. Longo, G. Siligardi, "Influence of elastase on alanine-rich peptide hydrogels", Biomaterials Science (2014), DOI: 10.1039/c4bm00001c
- Giuliano Siligardi, Rohanah Hussain, Simon Patching, Mary. K Phillips-Jones, "Ligand- and drug-binding studies of membrane proteins revealed through circular dichroism spectroscopy", Biochimica Et Biophysica Acta (bba) - Biomembranes, 1838 (1), 34-42 (2014), DOI: 10.1016/j.bbamem.2013.06.019
- [Science Highlight] Diamond Light Source, "Finding the key to combating bacterial resistance to a common antiseptic" (2014)
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