Jitka Waterman

Jitka Waterman is a Senior Industrial Liaison Scientist assisting industrial clients with structural biology and protein crystallography projects. 

She joined the Industrial Liaison Office in 2011 and brings over 25 years of expertise in the area of structural biology and macromolecular X-ray crystallography.

Jitka completed her PhD in Biophysics at the Masaryk University in the Czech Republic and at Lund University in Sweden, focusing on the structural analysis of pollutant-degrading haloalkane dehalogenases and maize beta-glucosidase involved in the regulation of plant development.

Jitka then worked as a postdoctoral research scientist at the University of York, where she studied the cobalamin biosynthetic pathway in Pseudomonas sp. in Keith Wilson's group, and later participated in collaborative projects within the biotech industry. Prior to joining Diamond, she worked as a postdoctoral fellow in Dave Stuart's group at the University of Oxford, where she researched influenza RNA-polymerase.

1. Structural and functional analyses of Burkholderia pseudomallei BPSL1038 reveal a Cas-2/VapD 
nuclease sub- family S. Shaibullah, N. Shuhaimi, D-S. Ker, N. Mohd-Sharif, K. L. Ho, A-H. Teh, J. 
Waterman, T-H. Tang, R-R. Wong, S. Nathan, R. Mohamed, M. J. Ng, S-Y. Fung, M. A. Jonet, M. 
Firdaus-Raih, C. L. Ng, Commun Biol. 6 (2023) 920-933. DOI: 10.1038/s42003-023-05265-4

2. Structural and functional characterization of three novel fungal amylases with enhanced stability and 
pH tolerance C. Roth, O.V. Moroz, J.P. Turkenburg, E. Blagova, J. Waterman, A. Ariza, L. Ming, S. 
Tianqi, C. Andersen, G.J. Davies, K. S. Wilson, Int J Mol Sci. 20 (2019) 4902-4916.
DOI: 10.3390/ijms20194902

3. Light-emitting Dehalogenases: Reconstruction of Multi-functional Biocatalysts R. Chaloupková, V. 
Lisková, M. Toul, K. Marková, E. Sebestová, L. Hernychová, M. Marek, G. Pinto, D. Pluskal, J. 
Waterman, Z. Prokop, J. Damborský, ACS Catal. 9 (2019) 4810-4823. DOI:
10.1021/acscatal.9b01031

4. Crystal structure and epitope analysis of house dust mite allergen Der f 21 S.L. Pang, K.L. Ho, J. 
Waterman, R.P. Rambo, A.H. Teh, I. Mathavan, G. Harris, K. Beis, Y.H. Say, M.S. Anusha, Y.Y. Sio, 
F.T. Chew, C.L. Ng, Sci Rep. 9 (2019) 4933-4945. DOI: 10.1038/s41598-019-40879-x

5. Evolutionary analysis as a powerful complement to energy calculations for protein stabilization K. 
Beerens, S. Mazurenko, A. Kunka, S.M. Marques, N. Hansen, M. Musil, R. Chaloupkova, J. 
Waterman, J. Brezovsky, D. Bednar, Z. Prokop, J. Damborsky ACS Catal. 8 (2018) 9420-9428. DOI: 
10.1021/acscatal.8b01677

6. Crystal structure and functional analysis of human C1ORF123 S.N. Rahaman, J. Mat Yusop, Z.A. 
Mohamed-Hussein, W.M. Aizat, K.L. Ho, A.H. Teh, J. Waterman, B.K. Tan, H.L. Tan, A.Y. Li, E.S. 
Chen, C.L. Ng, PeerJ. 6 (2018) e5377 1-25. DOI: 10.7717/peerj.5377

7. Crystallization and X-ray crystallographic analysis of recombinant TylP, a putative γ-butyrolactone 
receptor protein from Streptomyces fradiae N. Mohd-Sharif, S. Shaibullah, V. Givajothi, C.S. Tan, K.L. 
Ho, A.H. Teh, S.N. Baharum, J. Waterman, C.L. Ng, Acta Crystallogr F 73 (2017) 109-115.
DOI:10.1107/S2053230X17001212

8. Cloning, expression, purification, crystallization and X-ray crystallographic analysis of recombinant 
human C1ORF123 protein S.N. Rahaman, J. Mat Yusop, Z.A. Mohamed-Hussein, K.L. Ho, A.H. Teh, J. 
Waterman, C.L. Ng, Acta Crystallogr F, 72 (2016) 207-213. DOI: 10.1107/S2053230X16002016

9. Cloning, expression, purification, characterization, crystallization and X-ray crystallographic analysis 
of recombinant Der f 21 (rDer f 21) from Dermatophagoides farinae S.L. Pang, K.L. Ho, J. Waterman, 
A.H.Teh, F.T. Chew, C.L. Ng, Acta Crystallogr F, 71 (2015) 1396-1400.
DOI: 10.1107/S2053230X1501818X

10. Industrial Applications at Diamond E.J. Shotton, L.D. Connor, A. Dias, A.B. Kroner, C. Pizzey, T. 
Richter, J. Waterman, Synchrotron Radiation News, 27(3) (2014) 7-10. DOI: 
10.1080/08940886.2014.908698

11. Degradation of phytate by the 6-phytase from Hafnia alvei: a combined structural and solution study
A. Ariza, O.V. Moroz, E.V. Blagova, J.P. Turkenburg, J. Waterman, S.M. Roberts, J. Vind, C. Sjøholm, 
S.F. Lassen, L. De Maria, V. Glitsoe, L.K. Skov, K.S. Wilson, PLoS One, 8 (2013) e65062 1-13.
DOI: 10.1371/journal.pone.0065062

12. An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis E. Deery, S. 
Schroeder, A.D. Lawrence, S.L. Taylor, A. Seyedarabi, J. Waterman, K.S. Wilson, D. Brown, M.A. 
Geeves, M.J. Howard, R.W. Pickersgill, M.J. Warren, Nat Chem Biol, 11 (2012) 933-940.
DOI: 10.1038/nchembio.1086

13. Diamond: Open for Business E.J. Shotton, A. Dias, A.B. Kroner, C. Pizzey, J. Waterman, Synchrotron 
Radiation News, 24(6) (2011) 30-33. DOI:10.1080/08940886.2011.634316

14. Crystal structure of an intracellular subtilisin reveals novel structural features unique to this 
subtilisin family J. Vévodová, M. Gamble, G. Künze, A. Ariza, E. Dodson, D.D. Jones, K.S. Wilson,
Structure, 18 (2010), 744-755. DOI: 10.1016/j.str.2010.03.008

15. Structural and mutational analyses of the interaction between the barley alpha-amylase/subtilisin 
inhibitor and the subtilisin savinase reveal a novel mode of inhibition P.O. Micheelsen, J. Vévodová, 
L. De Maria, P.R. Ostergaard, E.P. Friis, K.S. Wilson, M. Skjøt, J Mol Biol, 380 (2008) 681-690.
DOI: 10.1016/j.jmb.2008.05.034

16. Weak activity of haloalkane dehalogenase LinB with 1,2,3-trichloropropane revealed by X-ray 
crystallography and microcalorimetry M. Monincová, Z. Prokop, J. Vévodová, Y. Nagata, J. 
Damborský, App Environ Microbiology, 73 (2007) 2005-2008. DOI: 10.1128/AEM.02416-06

17. Crystallization and preliminary structure analysis of CobE, an essential protein of cobalamin (vitamin 
B12) biosynthesis J. Vévodová, R.M. Graham, E. Raux, M.J. Warren, K.S. Wilson, Acta Crystallogr F,
61 (2005) 442-444. DOI: 10.1107/S1744309105006731

18. Structure/function studies on a S-adenosyl-L-methionine dependent uroporphyrinogen-III-C-methyltransferase (SUMT), a key regulatory enzyme of the tetrapyrrole biosynthesis J. Vévodová, 
R.M. Graham, E. Raux, H.L. Schubert, D.I. Roper, A.A. Brindley, A.I. Scott, C.A. Roessner, N.P.J. 
Stamford, M.E. Stroupe, E.D. Getzoff, M.J. Warren, K.S. Wilson J Mol Biol, 344 (2004) 419-433.
DOI: 10.1016/j.jmb.2004.09.020

19. Crystallization and preliminary X-ray analysis of an alkaline serine protease from Nesterenkonia sp S. 
Bakhtiar, J. Vévodová, R. Hatti-Kaul, X.-D. Su, Acta Crystallogr D, 59 (2003) 529-531.
DOI: 10.1107/s0907444902020747

20. Insights into the Functional Architecture of the Catalytic Center of a Maize Beta-Glucosidase Zm-p60.1 J. Vévodová, J. Zouhar, J. Marek, J. Damborský, X.-D. Su, B. Brzobohatý, Plant Physiology, 127 
(2001) 973-985. DOI: 10.1104/pp.010712

21. Purification, Crystallization and Preliminary X-ray Analysis of a Maize Cytokinin-glucoside-specific b-Glucosidase J.    Vévodová, J. Marek, J. Zouhar, B. Brzobohatý, X.-D. Su, Acta Crystallogr D 57 (2001) 
140-142. DOI: 10.1107/s0907444900014001

22. Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26 J. Marek, J. 
Vévodová, I. Kutá-Smatanová, Y. Nagata, L.A. Svensson, J. Newman, M. Takagi, J. Damborský, 
Biochemistry, 39 (2000) 14082-14086. DOI: 10.1021/bi001539c