Andrew Quigley

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Andrew is the Membrane Protein Laboratory coordinator/ Group Leader.

Email: andrew.quigley@diamond.ac.uk
Tel: +44 (0) 1235 778359

Key Research

Expression, purification and crystallisation of membrane proteins

Profile

  1. Profile
  2. Publications
Profile -

Andrew joined Diamond in 2018 from the SGC in Oxford where he was a Senior Post-Doctoral Researcher in the group of Prof. Liz Carpenter.  While at the SGC Andrew worked upon human integral membrane proteins including ion channels, GPCRs, transporters and membrane enzymes.  He helped to develop and manage the pipeline process that has led to 9 human membrane protein structures to date.  Specifically focusing on ZMPSTE24, GLUT3 and K2Ps.

Publications - +
  1. Birch, J, Cheruvara H, Gamage N, Harrison PJ, Lithgo R, Quigley, A. Changes in Membrane Protein Structural Biology. 2020. Biology 2020, 9, 401. doi: 10.3390/biology9110401
  2. Rödström KEJ, Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Müller T, Decher N & Carpenter EP. A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature 582, 443–447 (2020).doi: 10.1038/s41586-020-2250-8
  3. Mehmood S, Marcoux J, Gault J, Quigley A, Michaelis S, Young SG, Carpenter EP, Robinson CV. Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24.Nat Chem. 2016 Dec;8(12):1152-1158. doi: 10.1038/nchem.2591.
  4. Hresko RC, Kraft TE, Quigley A, Carpenter EP, Hruz PW. Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids. J Biol Chem. 2016 Aug 12;291(33):17271-82. doi: 10.1074/jbc.M116.730168.
  5. Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science. 2015 Mar 13;347(6227):1256-9. doi: 10.1126/science.1261512.
  6. Quigley KJ, Reynolds CJ, Goudet A, Raynsford EJ, Sergeant R, Quigley A, Worgall S, Bilton D, Wilson R, Loebinger MR, Maillere B, Altmann DM, Boyton RJ. Chronic Infection by Mucoid Pseudomonas aeruginosa Associated with Dysregulation in T-Cell Immunity to Outer Membrane Porin F. Am J Respir Crit Care Med. 2015 Jun 1;191(11):1250-64. doi: 10.1164/rccm.201411-1995OC.
  7. Quigley, A., Pryor EE Jr., Clark KM, Wiener MC, Carpenter EP, and Dumont ME. (2015) Ste24 Metalloproteases. In Encyclopedia of Inorganic and Bioinorganic Chemistry, R.A. Scott (Ed.). DOI: 10.1002/9781119951438.eibc2330
  8. Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP. The structural basis of ZMPSTE24-dependent laminopathies. Science. 2013 Mar 29;339(6127):1604-7. doi: 10.1126/science.1231513.

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