Harish Cheruvara

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Harish Cheruvara is a Research Assistant working in the Membrane Protein Laboratory.  Harish joined Diamond in 2017.

Email: harish.cheruvara@diamond.ac.uk
Tel: +44 (0) 1235 567571

Key Research

Expression, purification and crystallisation of membrane proteins

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Acerra, N. , Kad, N. M., Cheruvara, H. and Mason, J. M. (2014), Intracellular selection of peptide inhibitors that target disulphide‐bridged Aβ42 oligomers. Protein Science, 23: 1262-1274.

doi:10.1002/pro.2509

Cheruvara H, Allen-Baume VL, Kad NM, Mason JM. (2015), Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation. J. Biol. Chem. 290(12):7426-35

doi: 10.1074/jbc.M114.620484

 Prior to joining Diamond I worked at the University of Essex as a Post-doctoral researcher on a project aimed at validating the suitability of detergent-free solubilisation (using SMA; styrene maleic acid co-polymer) compared to detergent based solubilisation of membrane proteins for crystallisation and EM studies.  My PhD project was focused on α-synuclein; a soluble protein associated with Parkinson’s disease where I used atomic force microscopy and circular dichroism to show a new region of α-syn for inhibitor targeting.  I have experience of membrane protein expression, purification and crystallisation as well as basic molecular biology techniques.  At Diamond I support users in the MPL and developed new methods to work with membrane proteins.

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