Lorna Malone


Electron Microscope Scientist & Training Coordinator at the electron Bio-Imaging Centre (eBIC)

Lorna joined eBIC in January 2022.

Email: [email protected]
Tel: +44 (0) 1235 39 4182

Dr Lorna Malone is an experienced cryoEM scientist & training coordinator with a PhD in Biochemistry and Structural Biology.

Lorna obtained her PhD from the University of Sheffield (2021), where she conducted studies in the labs of Professor Neil Hunter (FRS) and Professor Matt Johnson. In her doctoral research, she utilised single-particle cryo-EM to investigate the internal mechanics of cytochrome b6f complex from plants and cyanobacteria. This work identified several new and interesting targets for genetic modification, potentially resulting in improved global crop yields, larger uptake of atmospheric CO2, and enhanced crop efficiency under changeable environmental conditions.

After completing her doctoral studies, Lorna joined eBIC in January 2022 as an Electron Microscope Scientist then took over the position of Training Coordinator in 2023. Lorna's research interests are diverse and she is involved in a range of collaborative single-particle projects. Lorna is also responsible for the coordination and development of training at eBIC, organising user meetings and managing the day-to-day operations and maintenance of a 200kV Talos Arctica.

Tyagi, G.1, Greenfield, J.L., Jones, B.E., Sharratt, W.N., Khan, K., Seddon, D., Malone, L.A., Cowieson, N., Evans, R.C., Fuchter, M.J., Cabral, J.T. (2022) Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles. JACS Au.  2, 12, 2670–2677. DOI: 10.1021/jacsau.2c00453.

Proctor, M.S.1Malone, L.A.1*, Farmer, D.A.1, Swainsbury, D.J.K., Hawkings, F.R., Pastorelli, F., Emrich-Mills, T.Z., Siebert, C.A., Hunter, C.N., Johnson, M.P., Hitchcock, A. (2022) Cryo-EM structures of the Synechocystis sp. PCC 6803 cytochrome b6f complex with and without the regulatory PetP subunit. Biochemical Journal. 479(13) 1487-1503. DOI: 10.1042/BCJ20220124
(*awarded front cover)

Swainsbury, D.J.K.1, Qian, P., Jackson, P.J., Faries, K.M., Niedzwiedzki, D.M., Martin, E.C., Farmer, D.A., Malone, L.A., Thompson, R.F., Ranson, N.A., Canniffe, D.P., Dickman, M.J., Holten, D., Kirmaier, C., Hitchcock, A. and Hunter, C.N. (2021) Structures of Rhodopseudomonas palustris RC-LH1 complexes with open or closed quinone channels. Science Advances. 7(3), eabe2631. DOI: 10.1126/sciadv.abe2631.

Malone, L.A.1, Proctor, M.S., Hitchcock, A., Hunter, C.N., and Johnson, M.P. (2021) Cytochrome b6f – orchestrator of photosynthetic electron transfer. Biochimica et Biophysica Acta - Bioenergetics. 1862(5), 1-21. DOI: 10.1016/j.bbabio.2021.148380.

Malone, L.A.1, Qian, P., Mayneord, G.E., Hitchcock, A., Farmer, D.A., Thompson, R., Swainsbury, D.J.K., Ranson, N.A., Hunter, C.N. and Johnson, M.P. (2019) Cryo-EM structure of the spinach cytochrome b6f complex at 3.6 Å resolution. Nature 575, 535-539. DOI: 10.1038/s41586-019-1746-6.

Mayneord, G.E.1, Vasilev, C., Malone, L.A., Swainsbury, D.J.K., Hunter, C.N. & Johnson M.P. (2019) Single-molecule study of redox control involved in establishing the spinach plastocyanin-cytochrome b6f electron transfer complex. Biochimica et Biophysica Acta - Bioenergetics, 1860(7), 591-599. DOI: 10.1016/j.bbabio.2019.06.013.

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