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  1. Science
  2. Research
  3. Science Highlights
  4. 2010

  • highlight
    The structure of polyhedra microcrystals

    The structure of polyhedra microcrystals Nov 15, 2010

    Virus infections in a number of insect families generally culminate in the occlusion of between one and several thousand virus particles within ...

  • highlight
    CD spectroscopy of DNA nano-materials

    CD spectroscopy of DNA nano-materials Nov 10, 2010

    The structure determination of biomolecules, in particular of DNA and of proteins, is of utmost importance to understand their function in ...

  • highlight
    Structural insight into M-band assembly and mechanics from the titinobscurin- like-1 complex

    Structural insight into M-band assembly and mechanics from the titinobscurin- like-1 complex Nov 5, 2010

    In muscle, assembly of ordered striated myofibrils requires the integration of hundreds of protein subunits in a sequential, regulated way by ...

  • highlight
    Architecture of a eukaryotic transpososome

    Architecture of a eukaryotic transpososome Nov 4, 2010

    Transposons are pieces of DNA that can jump from one place to another in the genome of a cell and they make up a surprisingly large proportion of ...

  • highlight
    Application of kinoform lens for X-ray reflectivity analysis

    Application of kinoform lens for X-ray reflectivity analysis Nov 2, 2010

    X-ray reflectivity (XRR) is a non-destructive technique widely used for thin layered materials characterization. The brilliance achieved by third ...

  • highlight
    Characterization of monocrystalline diamond films as X-ray detectors

    Characterization of monocrystalline diamond films as X-ray detectors Oct 27, 2010

    Monocrystalline diamond films with several metal contacts were characterized as radiation detectors in terms of responsivity as a function of ...

  • highlight
    Activation of a front line TB drug

    Activation of a front line TB drug Oct 26, 2010

    Nicotinamidase catalyzes hydrolysis of nicotinamide to nicotinic acid and ammonia, in the NAD(+) salvage pathway. This enzyme activity has a ...

  • highlight
    A multi-technique study of polymorphism in NaNb03

    A multi-technique study of polymorphism in NaNb03 Oct 14, 2010

    A polar phase of the perovskite NaNbO3 has been successfully synthesised using sol-gel techniques. Detailed characterisation of this phase has ...

  • highlight
    Cell Semaphore

    Cell Semaphore Oct 13, 2010

    Axons are the communication channels of the body. Up to a metre in length, they connect parts of the body to the brain, carrying signals from ...

  • highlight
    Crystallographic analysis of the interaction of splicing co-regulators polypyrimidine tract binding protein (PTB) and Raver1

    Crystallographic analysis of the interaction of splicing co-regulators polypyrimidine tract binding protein (PTB) and Raver1 Oct 13, 2010

    The regulation of the alternative splicing of messenger RNA allows mammals and other eukaryotic organisms to greatly enrich the diversity of the ...

  • highlight
    Nbs1 – a new framework for understanding DNA-damage signalling and repair

    Nbs1 – a new framework for understanding DNA-damage signalling and repair Oct 13, 2010

    A protein complex called MRE11-RAD50-NBS1 (MRN) coordinates the detection and repair of one of the most hazardous forms of DNA damage, the double ...

  • highlight
    Propagation of repressive chromatin marks by PRC2 - how EED recognises histone tails

    Propagation of repressive chromatin marks by PRC2 - how EED recognises histone tails Oct 13, 2010

    Polycomb group proteins have an essential role in maintaining repressive epigenetic states and silencing unwanted gene expression during ...

  • highlight
    Studying grain level deformation in polycrystalline engineering materials - micro-beam Laue and other micro diffraction methods

    Studying grain level deformation in polycrystalline engineering materials - micro-beam Laue and other micro diffraction methods Oct 13, 2010

    During the past 18 months, we have developed a novel micro-beam Laue diffraction setup on beamline B16 with a dedicated in situ loading ...

  • highlight
    High resolution powder diffraction studies of mixed-metal layered phosphates

    High resolution powder diffraction studies of mixed-metal layered phosphates Oct 12, 2010

    The search for new and improved ion-exchange materials for nuclear waste remediation continues to be an important topic, especially given the ...

  • highlight
    Moving towards a green, hydrogen-based economy: structure of an oxygen-tolerant, highly active hydrogenase

    Moving towards a green, hydrogen-based economy: structure of an oxygen-tolerant, highly active hydrogenase Oct 12, 2010

    The three-dimensional structure of [NiFeSe] hydrogenase from D. vulgaris Hildenborough in its oxidised, “as isolated” state has been determined ...

  • highlight
    Complex between Neisseria meningitidis factor H binding protein and two domains from human complement factor H

    Complex between Neisseria meningitidis factor H binding protein and two domains from human complement factor H Oct 12, 2010

    The structure of a protein complex between a bacterial and a human protein solved using data collected at Diamond Light Source (UK) and the ESRF ...

  • highlight
    X-ray crystal structure and time-resolved spectroscopy of the blue carotenoid violerythrin

    X-ray crystal structure and time-resolved spectroscopy of the blue carotenoid violerythrin Oct 11, 2010

    Violerythrin, a blue colored carotenoid, has been investigated by X-ray crystallography and by steady-state and ultrafast time-resolved absorption ...

  • highlight
    Structural Insights into the activation of phosphoinositide 3-kinase by influenza A viruses

    Structural Insights into the activation of phosphoinositide 3-kinase by influenza A viruses Oct 11, 2010

    Seasonal epidemics and worldwide pandemics caused by influenza A viruses are of continuous public health concern. During infection, the viral ...

  • highlight
    Heme-like coordination chemistry within nanoporous molecular crystals

    Heme-like coordination chemistry within nanoporous molecular crystals Oct 11, 2010

    Crystal engineering of nanoporous structures has not yet exploited the heme motif so widely found in proteins. X-ray diffraction (XRD) analysis on ...

  • highlight

    An Adaptable Peptide-Based Porous Material Oct 11, 2010

    Porous materials have wide ranging applications in areas such as hydrogen storage, catalysis and drug delivery. In rigid porous materials such as ...

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