Peter Harrison

Peter joined eBIC as a Post-Doctoral Research Associate in September 2020 to work between eBIC and the Membrane Protein Laboratory (MPL) on the cryo-EM of membrane proteins.

Before moving to eBIC, Peter did his Ph.D. in Chemistry at the University of Warwick, before working in the Department of Chemistry at the University of Edinburgh and in the Division of Structural Biology at the University of Oxford. His research focused on the structural biology, biophysics and enzymology of higher order membrane enzyme complexes. His research interests include enzymology of membrane proteins and enzymes of natural product biosynthesis.

J. Huo, A. Le Bas, R. R. Ruza, H. M. E. Duyvesteyn, H. Mikolajek, T. Malinauskas, T. Kit Tan, P. Rijal, M. Dumoux, P. N. Ward, J. Ren, D. Zhou, P. J. Harrison, M. Weckener, D. K. Clare, V. K. Vogirala, J. Radeke, L. Moynié, Y. Zhao, J. Gilbert-Jaramillo, M. L. Knight, J. A. Tree, K. R. Buttigieg, N. Coombes, M. J. Elmore, M. W. Carroll, L. Carrique, P. N. M. Shah, W. James, A. R. Townsend, D. I. Stuart, R. J. Owens & J. H. Naismith, Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2. Nat. Struct. Mol. Biol., 2020, 27, 846.

P. J. Harrison, K. Gable, N. Somashkerappa, V. Kelly, D. J. Clarke, J. H. Naismith, T. M. Dunn & D. J. Campopiano, Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase. J. Lipid. Res., 2019, 60, 953.

P. J. Harrison, T. Dunn & D. J. Campopiano, Sphingolipid biosynthesis in man and microbes. Nat. Prod. Rep., 2018, 35, 921.

M. Wang, L. Moynié, P. J. Harrison, V. Kelly, A. Piper, J. H. Naismith & D. J. Campopiano, Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters. Nat. Chem. Biol., 2017, 13, 660.

S. Z. Awan, J. O. Chandler, P. J. Harrison, M. J. Sergeant, T. D. Bugg & A. J. Thompson, Promotion of Germination Using Hydroxamic Acid Inhibitors of 9-cis-Epoxycarotenoid Dioxygenase. Front. Plant Sci., 2017, 8, 357.

P. J. Harrison, S. A. Newgas, F. Descombes, S. A. Shepherd, A. J. Thompson & T. D. H. Bugg, Biochemical characterization and selective inhibition of β-carotene cis-trans isomerase D27 and carotenoid cleavage dioxygenase CCD8 on the strigolactone biosynthetic pathway. FEBS J., 2015, 282, 3986.

P. J. Harrison & T. D. H. Bugg, Enzymology of the carotenoid cleavage dioxygenases: reaction mechanisms, inhibition and biochemical roles. Arch. Biochem. Biophys., 2014, 544, 105.

J. M. Van Norman, J. Zhang, C. I. Cazzonelli, B. J. Pogson, P. J. Harrison, T. D. H. Bugg, K. X. Chan, A. J. Thompson & P. N. Benfey, Periodic root branching in Arabidopsis requires synthesis of an uncharacterized carotenoid derivative. Proc. Natl. Acad. Sci. USA, 2014, 111, E1300.

M. J. Sergeant, P. J. Harrison, R. Jenkins, G. R. Moran, T. D. H. Bugg & A. J. Thompson, Phytotoxic effects of selected N-benzyl-benzoylhydroxamic acid metallo-oxygenase inhibitors: investigation into mechanism of action. New J. Chem., 2013, 37, 3465.