JoVE (the Journal of Visualized Experiments)
The iNEXT Discovery Methods Collection introduces the most important methods for the structural analysis of macromolecules, applications in fragment-based lead drug discovery, the investigation of macromolecular structures in their native environment, and high throughput approaches for structural determination. It is funded by iNEXT Discovery.
Click here to see the full iNEXT Methods catalogue.
Fragment screening (XChem /I04-1):
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
Long wavelength phasing (I23):
Serial and in situ crystallography (I24):
Fixed Target Serial Data Collection at Diamond Light Source
Serial and in situ crystallography (VMXi): TBC
Sub-micron crystallography (VMXm):
A Sample Preparation Pipeline for Microcrystals at the VMXm Beamline
Biological small angle X-ray scattering (B21): TBC
Cryo electron microscopy (eBIC):
Single Particle Cryo-Electron Microscopy: From Sample to Structure
Cryo soft X-ray tomography (B24):
A 3D Cartographic Description of the Cell by Cryo Soft X-ray Tomography
Cryo-Structured Illumination Microscopic Data Collection from Cryogenically Preserved Cells
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
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