ARIA - Access to Research Infrastructure Administration
A collection of cloud services provided by Instruct to research infrastructures, facilities and user communities within structural biology and related fields.
BAGs - Block Allocation Groups
eBIC - the Electron Bio-Imaging Centre (cryo-EM)
ERIC - European Research Infrastructure Consortium
HEDC - High End Data Collection
Expert users who can use synchrotron beamlines, high frequency NMR magnets and state-of-the-art cryo-EM instruments
iNEXT - Infrastructure for NMR, EM and X-rays for Translational Research
JRA - Joint Research Activity
These are intended to maximise the output of fragment screening, standardise conditions for lamella preparation using cryo-focussed ion beam microscopes, and work towards the development of 3D cryo super-resolution visible light fluorescence microscopy designs as well as scripts for the automatisation of 3D referencing (fiducialisation) in super resolution correlative light x-ray microscopy (SRCLXM).
ORCID - Open researcher and contributor identification
ORCID provides a persistent digital identifier that distinguishes you from every other researcher and, through integration in key research workflows such as manuscript and grant submission, supports automated linkages between you and your professional activities ensuring that your work is recognized. See https://orcid.org/
PBS - Principal Beamline Scientist
PID - Proposal Identification number (iNEXT / Instruct ARIA system)
UAS - User Adminstration System (Diamond Light Source)
VID - Visit Identification number (iNEXT / Instruct ARIA system)
VMXi - Versatile Macromolecular Xtallography In Situ (Diamond beamline)
VMXm - Versatile Macromolecular Xtallography Micro/nanofocus beamline
Fragment screening - iNEXT provides crystallographic screening for validated ligand-binding and fragment-based drug discovery. Access ranges from crystallization trials all the way to data for several crystal structures.
Instruct-ERIC - A pan-European research infrastructure in structural biology (part of the European Research Infrastructure Consortium).
Mail-in SAXS - A macromolecular sample is sent to iNEXT and a preliminary characterization by SAXS is performed to obtain low-resolution shape characterization and determination of interactions in macromolecular complexes.
Modality - type of access provided (e.g. signature access).
Rapids (rapid access) - Provides quick and urgent access to a beamline. Users must contact the Principal Beamline Scientist prior to submitting a proposal as some beamlines have a restricted amount of rapid access available.
Remote access - Access to experimental data using an internet connection without the need to visit the facility, for example the MX beamlines at Diamond, including I04-1 and I24, have been highly automated. Most experiments are feasible remotely with minor exceptions such as humidity control or those at biological containment level III.
Signature access - For when users have a specific application in mind for their research. Signature access is offering fragment screening (X-ray or NMR-based), biophysics to obtain details in kinetics and thermodynamics of macromolecular interactions, EM/CLEM tomography experiments, X-ray imaging, in-cell NMR, serial crystallography, long-wavelength crystallography, or nano-crystallography. Like for the Technology Tracks, these access possibilities do not require prior experience with the technology requested: the experiments will be supervised by skilled specialists. User research proposals can be submitted and will be peer-reviewed on a continuous basis.
Technology tracks - Users select this when they already know which technology they want to use: solid state or solution state NMR, single particle cryo-EM (either from sample to 2D classes to structure, or from 2D classes to structure), or X-ray crystallography or Small-Angle X-ray Scattering experiments. Background knowledge is not essential: if necessary, users will receive expert guidance. User research proposals can be submitted and will be peer-reviewed on a continuous basis.
Thematic calls - To attract extra researchers from non-structural biology communities, iNEXT-Discovery will organize Thematic Calls dedicated to Health, Food, Biotechnology or Biomaterials research. These Thematic Calls will be announced on the iNEXT-Discovery website with a clear deadline for proposal submission. If necessary, proposals will be pooled and prioritized before peer-review to optimize the available capacity.
Translational - The "translation" of basic scientific findings in a laboratory setting into potential treatments for human diseases.
Units of access - E.g. shifts, days, hours, campaigns.
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
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