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Aurora-A is an essential enzyme which is required for human cells to multiply. Aurora-A has higher activity than normal in many human cancers and is a target for the development of anti-cancer drugs, some of which are in clinical trials. X-ray crystallography is used to characterise how these small molecules interact with Aurora-A, and these data provide information on how they work and allow the production of a new generation of more potent inhibitors.
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Over one hundred members of the Oxfordshire Federation of Woman’s Institutes (WI) gathered together at Diamond Light Source this week to mark the finale of one of the largest art/science projects in the UK.
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The Institution of Mechanical Engineers (IMechE) has joined forces with 100 of the UK’s leading engineering companies, universities and colleges, including Diamond Light Source, in a drive to crack a skills shortage in the profession.
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The first paper to be published on research carried out at Diamond has appeared in the Proceedings of the National Academy of Sciences.
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Scientific links between Diamond Light Source Ltd, the UK's new synchrotron science facility, and two Russian science institutes – the Kurchatov Institute and the Shubnikov Institute of Crystallography - were strengthened this week when these partners signed a Memorandum of Understanding (MoU) on collaborative research.
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Her Majesty The Queen, accompanied by His Royal Highness The Duke of Edinburgh, officially opened Diamond Light Source, the UK’s new national synchrotron facility today (Friday 19 October 2007). Diamond is the largest science facility to be built in the UK for 40 years and is set to play a major role in facilitating ground breaking science that is carried out in this country over the coming decades.
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The first publication from Diamond Light Source utilised the synchrotron’s high intensity x-rays and a diamond-anvil cell on the Extreme Conditions beamline I15, to study the unique behaviour of sodium at high pressures. This research was carried out by a team from the Centre for Science at Extreme Conditions at the University of Edinburgh, working in collaboration with the I15 beamline team.1
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Dr Paul Schofield is a researcher in mineral sciences in the Department of Mineralogy at the Natural History Museum (NHM). Paul used I18 to study a range of earth and life science specimens from the collections at the NHM. The spectroscopic data he obtained should provide an insight into natural processes, environmental systems and Earth and planetary history.
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The first users on the I22 Non-Crystalline Diffraction beamline, Professor Tim Wess and his team at the University of Cardiff, have been able to analyse the state of the collagen within parchment and its degenerative change to gelatine. Understanding the deterioration process will allow them how to preserve parchment for future generations. In cases where precious parchments may be too damaged or at risk, they have developed techniques to image written work without unrolling the fragile ...
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David Eastwood is a post-graduate student working with Professor Brian Tanner at the University of Durham. David used I16 to carry out detailed examinations of new sensors to be used in computer components that ‘read’ the magnetic information stored in its memory.
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Synchrotron-based Earth and Environmental Science Research Initiative (Enirosynch2): Travel and Subsistence Funding
Applications are invited for travel and subsistence awards to fund research trips to international synchrotron radiation facilities. This small initiative is jointly funded by the NERC and Diamond Light Source (DLS) and aims to build and develop the use of synchrotron radiation techniques in all fields of Earth and Environmental sciences research.
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The first users on the I22 Non-Crystalline Diffraction beamline, Professor Tim Wess and his team at the University of Cardiff, have been able to analyse the state of the collagen within parchment and its degenerative change to gelatine.
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Superoxide Dismutase (SOD) is a key enzyme that is responsible for removing harmful oxygen radicals from cells by catalysing their breakdown into hydrogen peroxide and water. The synchrotron radiation at Diamond was used to determine the molecular structure of a SOD which contains the metal manganese from the parasitic worm C. elegans. The structure will help us understand how the enzyme works and how it chooses manganese over other metals. The picture shows the four protein chains in ...
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Diamond has appointed a trio of artists to have a presence on site and work with members of the science team over the next 12 months.
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This week marks the dawn of a new era of scientific endeavour as Diamond Light Source, the UK’s brand new synchrotron facility, opens its doors for business and welcomes its very first scientific users. Top academic teams from Durham, Oxford, Leicester and London have been selected to be the first users of one of the brightest sources of light in the world that will enable them to find out more than ever before about the secret structure of the world around us.
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Three short months after celebrating the first generation of synchrotron light, Diamond Light Source announced today that it has reached the final milestone in the construction of a facility that is destined to change the landscape of UK science.
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Diamond Light Source Ltd is now eligible for funding from Facility Development Project Grant Scheme, managed by STFC. This scheme was developed to encourage academic researchers and others to put forward innovative and creative ideas for development of facility instrumentation, detectors, analytical capabilities and sample environments among others.
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On the night of September 4th 2006 Diamond succeeding in circulating the first electrons in the storage ring at 3 GeV.
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At 2.00am on Tuesday 30th May 2006 (Spring Bank Holiday Monday night shift!), Diamond's accelerator team achieved stored beam in the 561.6 metre Storage Ring, which in turn allowed the first observation of synchrotron light.
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Diamond's accelerator team had a fantastic reason to celebrate last night, Thursday 4th May 2006.
