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Industrial Liaison Group:
Tel: +44 (0) 1235 778797
E-mail: industry@diamond.ac.uk
The rise in antibiotic resistance has increased rapidly over the last decade, with pathogens such as pseudomonas aeruginosa carrying resistance to many drugs available. The recent COVID-19 pandemic has highlighted the importance of novel drugs to treat this species due to its association with ventilator-associated pneumonia, amongst other infections.
An attractive target for this pathogen is the LpxA enzyme which inhibits its growth. Although part of an existing series of enzymes in the same pathway – that have already been validated – this will represent a novel mode of action that circumvents existing target and class-based resistance mechanisms.
Optimised using macromolecular crystallography (MX) at Diamond, Evotec, X-Biotix Therapeutics and X-Chem explored this targeted therapy as an approach that is less likely to damage the healthy microbiota compared to broad-spectrum antibiotics. Find out what the study revealed.
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Industrial Liaison Office
