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The vast majority of the electronic devices today are based on silicon technology and their performance and operation depend on the movement and mobility of electronic charge. This mode of operation sets the limits on power consumption, operation speed and results in potential device overheating, particularly at fast switching speeds. At the same time, it is well-known that electrons also possess a spin and the idea of manipulating this property led to a relatively new field of
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With the arrival of World Alzheimer’s Day (21st September), Diamond Light Source takes a closer look at the research taking place at the synchrotron into the disease that is the most common cause of dementia and affects over 400,000 people in the UK.
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Great Britain is an island nation, with over 11,000 miles of coastline*. But the coastline is continually changing, due to the process of coastal erosion. A group of scientists have been using Diamond Light Source to study the weathering of shale cliffs in North Yorkshire to understand physical and chemical interactions on the molecular scale that could cause weakening of the cliffs , including the intriguing possibility that a novel microbial community might be responsible.
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Metal-on-metal hip replacement is a treatment for “wear and tear” arthritis (osteoarthritis) – one of the commonest diseases in the world. These hip replacements use cobalt chrome alloy for both bearing surfaces and are the only type that can be made thin enough to enable resurfacing of both sides of the worn hip joint, called a hip resurfacing. The most common type was developed 13 years ago in the UK and has been adopted world wide. One million people now have a metal-on-metal hip ...
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Battlefield use of depleted uranium (DU) weapons has generated considerable controversy because of the potential long-term effects on the environment and on the health of people exposed to it. DU projectiles have been used as armour-piercing weapons by both the British and American militaries and deployed in the Balkans and both Gulf wars. Upon impact the metal combusts and a fraction is dispersed as uranium oxide particulates. Inhalation of these particulates constitutes the main long-term ...
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Framework structures are molecular cages which are capable of selectively trapping atoms, ions and molecules within the cage. Materials that adopt framework structures have attracted significant attention recently as they have potential applications in a wide range of areas, including catalysis and the pharmaceutical industry. Currently almost all existing framework structures are neutral or negatively charged, but a group led by researchers from the University of Liverpool in collaboration ...
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During a visit to Diamond Light Source, the UK’s national synchrotron science facility, on Friday 9th July, Prof. Venki Ramakrishnan, winner of the 2009 Nobel Prize for Chemistry, unveiled the World’s largest diffraction pattern – an innovative textile project which has had stitches added to it by over 5000 people in the UK, Europe and America.
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Peptoids are analogues of α-peptides where the backbone is achiral due to the proteinogenic side chains being relocated from the α-C to the amide nitrogen. In the peptoids discussed here, chiral centres are present in the side chains thus making them suitable for chiroptical analysis. The presence of tertiary amides complicates NMR interpretation which means that circular dichroism (CD) becomes an invaluable tool for the study of peptoid conformation. Understanding of the spatial orientation ...
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Diamond is taking part in the 350th Anniversary of the Royal Society and their special Science Exhibition at the Southbank Centre in London.
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The two prototypical members of the Fibroblast growth factors (FGF) family, FGF-1 and-2, have fundamentally distinct binding requirements and the secondary structures induced by binding of polysaccharides are also distinct. Analogues of HS, which are active with FGF-1 act in essentially the same way as the natural ligand, but not in the case of FGF-2. This improves our understanding of the structural basis of the signalling complexes and is vital for the design of analogues, which can be ...
