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  1. Diamond Light Source
  2. News and Literature
  3. Annual Review
  4. Diamond Annual Review 2018
  5. Science Group Updates
  6. Spectroscopy Group

Spectroscopy Group

  • annual review
    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist

    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist Jun 1, 2018

    To design such small molecules, a detailed map of the interactions between GLP-1 and its receptor was needed.

  • annual review
    Structural insights into the mechanism of bacterial ABC transporters

    Structural insights into the mechanism of bacterial ABC transporters Jun 1, 2018

    Bacteria utilise ATP-binding cassette (ABC) transporters to import nutrients and detoxify themselves. These transporters have been shown to exist in wide open conformations that permit the access of many substrates in the binding pocket.

  • annual review
    Structure of the surface layer surrounding Caulobacter crescentus bacteria

    Structure of the surface layer surrounding Caulobacter crescentus bacteria Jun 1, 2018

    Many types of single-celled microorganisms such as bacteria are covered with a protective outer layer of proteins known as the S-layer.

  • annual review
    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint.

    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint. Jun 1, 2018

    In all cells derived from animals, plants, fungi and protozoa a single protein called UGGT acts as a quality control checkpoint that inspects secreted glycoproteins.

  • annual review
    Insights into the mechanism of colistin resistance from crystal structures of MCR-1

    Insights into the mechanism of colistin resistance from crystal structures of MCR-1 Jun 1, 2018

    Gram-negative bacteria that are extensively resistant to multiple antibiotics are an ever-increasing global threat. Colistin is an antibiotic used as the last line of defence against highly resistant Gram-negative bacteria. However, in recent years bacteria have emerged with resistance to this crucial antibiotic.

  • annual review
    How human endoglin captures its ligand BMP9

    How human endoglin captures its ligand BMP9 Jun 1, 2018

    Endoglin (ENG)/CD105 is a mammalian glycoprotein that is found in the membranes of cells that line blood vessels. It is essential for healthy heart development and blood vessel growth, but conversely it is also involved in preeclampsia and can help tumours establish their blood supply.

Update

Following the restructuring of the Diamond Science Division, the Diamond Spectroscopy Group is built around four beamlines; the Microfocus Spectroscopy beamline (I18) the Core X-ray Absorption Spectroscopy (XAS) beamline (B18) and the two independently operating branches of the Versatile X-ray Absorption Spectroscopy beamline, I20-scanning and I20-EDE. Read more ...

  • annual review
    Phosphorylation Enhances Cytochrome c Dynamics to Modulate its Function

    Phosphorylation Enhances Cytochrome c Dynamics to Modulate its Function Jun 1, 2018

    Some diseases, including cancer and ischemia (an inadequate blood supply to an organ or part of the body), involve reversible phosphorylation at a given site on the cytochrome c protein. Cytochrome c is essential for human metabolism and contains a heme iron, which allows it to function as an electron carrier. To understand the molecular basis underlying the effects of phosphorylation, an international team of researchers has used several methods to analyse the structure, dynamics and ...

  • annual review
    Atomically Dispersed Gold Species Can Act as Catalysts

    Atomically Dispersed Gold Species Can Act as Catalysts Jun 1, 2018

    Current production process for vinyl chloride, the monomer used in PVC and everything from piping and tubing to gels and lubricants, relies on a mercury-based catalyst. Mercury is one of the most toxic substances on the planet, and the UN recently ratified the Minamata Convention, meaning that a more environmentally-friendly alternative is required.

  • annual review
    Nanocrystallites on micro-catalysts brought into focus

    Nanocrystallites on micro-catalysts brought into focus Jun 1, 2018

    The Fischer-Tropsch process is used to convert hydrogen and carbon monoxide to hydrocarbons. It relies on the use of catalysts, which make the process more efficient and can control which products are produced, from long hydrocarbon chains to heavy waxes.

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Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.

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