Nerves and blood vessels grow to the right places because they receive instructions to keep them on the correct path. These instructions come from pairs of molecules: receptors and ligands on the surface of different cells. When a matched pair makes contact in a specific ‘handshake’ it directs the cell carrying the receptor right or left, just like SatNav. If we understand what different handshakes look like, we can design drugs that to strengthen them – to help nerve regeneration, or stop them - possibly preventing cancer cells spreading. To see the handshake in detail we need a synchrotron. Using Diamond we found (see below) that the ligand (Ephrin, blue) presents a loop grasped by the receptor (Eph), a beautifully specific interaction that defines the cell navigation signal.
|Eph receptor||Ephrin ligand|
Tom Bowden, Radu Aricescu, Jo Nettleship, Christian Siebold, Weixian Lu,Nahid Rahman, Karl Harlos, Jon Grimes, Stephen Graham, Ray Owens, Yvonne Jones & Dave Stuart Structural Biology, Nuffield Department of Medicine, Oxford University. Funded by CRUK and MRC.
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