Keep up to date with the latest research and developments from Diamond. Sign up for news on our scientific output, facility updates and plans for the future.
Analysing cells on a cell-by-cell basis using infrared microspectroscopy can reveal important biochemical information, providing insight into diseases, and drug-cell interactions. However, for visible and infrared microscopy, the cells have to be preserved and dried; also, water is a strong infrared absorber and obscures the spectrum of the cells under investigation. Analysing dried fixed cells reduces the relevance of the results since they are not in their natural environment.
Researchers investigated building a sample environment that would allow the cells to be kept alive in water during infrared microspectroscopy analysis. The sample chamber needed an amount of water small enough to not be a major problem, but large enough to allow the correct flow of nutrients to the cells, to keep them alive for a prolonged period of time. It also had to be temperature-controlled.
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
Copyright © 2022 Diamond Light Source
Diamond Light Source Ltd
Harwell Science & Innovation Campus
Diamond Light Source® and the Diamond logo are registered trademarks of Diamond Light Source Ltd
Registered in England and Wales at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom. Company number: 4375679. VAT number: 287 461 957. Economic Operators Registration and Identification (EORI) number: GB287461957003.