Designing ultrafast electron tomography

This project focuses on the development of new methods for cryo-Electron Tomography (cryo-ET). New electron detectors allow saving up to 250 frames per second at full sensor size. However, the potential benefits from higher frame rates are not yet entirely utilised in cryo-ET due to the current data collection schemes. We aim to develop ultrafast cryo-ET, which would significantly speed up data collection and improve the quality of collected tomograms.

Tomography and cryo-ET in particular are fast developing fields with potential to change many aspects of science and technology, while programming skills are generally prized by many employers. You will work in a state-of-the-art facility for cryo-ET data acquisition and analysis and will help to develop algorithms to improve the speed of data collection, tomogram alignment and the quality of 3D-reconstruction. You will learn general methods used in tomography, specifically cryo-ET and will design new algorithms with built-in potential for the accommodation of emerging novel techniques. The project will be coordinated with microscope developers, Thermo Fisher Scientific.