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  1. Diamond Light Source
  2. News and Literature
  3. Annual Review
  4. Diamond Annual Review 2019
  5. Science Group Updates
  6. Spectroscopy Group

Spectroscopy Group

  • annual review
    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist

    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist Jun 1, 2018

    To design such small molecules, a detailed map of the interactions between GLP-1 and its receptor was needed.

  • annual review
    Structural insights into the mechanism of bacterial ABC transporters

    Structural insights into the mechanism of bacterial ABC transporters Jun 1, 2018

    Bacteria utilise ATP-binding cassette (ABC) transporters to import nutrients and detoxify themselves. These transporters have been shown to exist in wide open conformations that permit the access of many substrates in the binding pocket.

  • annual review
    Structure of the surface layer surrounding Caulobacter crescentus bacteria

    Structure of the surface layer surrounding Caulobacter crescentus bacteria Jun 1, 2018

    Many types of single-celled microorganisms such as bacteria are covered with a protective outer layer of proteins known as the S-layer.

  • annual review
    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint.

    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint. Jun 1, 2018

    In all cells derived from animals, plants, fungi and protozoa a single protein called UGGT acts as a quality control checkpoint that inspects secreted glycoproteins.

  • annual review
    Insights into the mechanism of colistin resistance from crystal structures of MCR-1

    Insights into the mechanism of colistin resistance from crystal structures of MCR-1 Jun 1, 2018

    Gram-negative bacteria that are extensively resistant to multiple antibiotics are an ever-increasing global threat. Colistin is an antibiotic used as the last line of defence against highly resistant Gram-negative bacteria. However, in recent years bacteria have emerged with resistance to this crucial antibiotic.

  • annual review
    How human endoglin captures its ligand BMP9

    How human endoglin captures its ligand BMP9 Jun 1, 2018

    Endoglin (ENG)/CD105 is a mammalian glycoprotein that is found in the membranes of cells that line blood vessels. It is essential for healthy heart development and blood vessel growth, but conversely it is also involved in preeclampsia and can help tumours establish their blood supply.

Sofia Díaz-Moreno, Science Group Leader

Following the restructuring of the Diamond Science Division, the Diamond Spectroscopy Group is built around four beamlines; the Microfocus Spectroscopy beamline (I18) the Core X-ray Absorption Spectroscopy (XAS) beamline (B18) and the two independently operating branches of the Versatile X-ray Absorption Spectroscopy beamline, I20-scanning and I20-EDE. Read more ...

  • annual review
    Identifying active iron sites for NO<sub>x</sub> pollution control in porous matrices

    Identifying active iron sites for NOx pollution control in porous matrices Aug 8, 2019

    Diesel is the fuel of choice for heavy goods vehicles, but diesel combustion generates nitrogen oxides (NOx) that are known to be harmful to human health;

  • annual review
    Tumour penetration by novel precious-metal anticancer drug candidate

    Tumour penetration by novel precious-metal anticancer drug candidate Aug 8, 2019

    Some of the most effective cancer treatments involve platinum-based drugs, but resistance to platinum compounds is increasing and there is an urgent need to find alternatives. A team from the University of Warwick has discovered a new osmium-based (Os-based) anti-cancer agent, FY26, which exhibits high potency against a range of cancer cell lines and is capable of overcoming platinum resistance. Before it can be tested in clinical trials, the team needs to understand fully how it works.

  • annual review
    Atomic insights into new fast-charging lithium-ion battery materials

    Atomic insights into new fast-charging lithium-ion battery materials Aug 8, 2019

    The increasing energy storage needs of electric vehicles and mobile devices is driving research into higher performance batteries. One particular challenge for some applications is safely charging/discharging fast enough, and most materials that offer both high power and fast charging require nanoparticles that are expensive to make and difficult to produce in large quantities.

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Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.

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