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  1. Diamond Light Source
  2. News and Literature
  3. Annual Review
  4. Diamond Annual Review 2019
  5. Science Group Updates
  6. Soft Condensed Matter Group

Soft Condensed Matter Group

  • annual review
    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist

    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist Jun 1, 2018

    To design such small molecules, a detailed map of the interactions between GLP-1 and its receptor was needed.

  • annual review
    Structural insights into the mechanism of bacterial ABC transporters

    Structural insights into the mechanism of bacterial ABC transporters Jun 1, 2018

    Bacteria utilise ATP-binding cassette (ABC) transporters to import nutrients and detoxify themselves. These transporters have been shown to exist in wide open conformations that permit the access of many substrates in the binding pocket.

  • annual review
    Structure of the surface layer surrounding Caulobacter crescentus bacteria

    Structure of the surface layer surrounding Caulobacter crescentus bacteria Jun 1, 2018

    Many types of single-celled microorganisms such as bacteria are covered with a protective outer layer of proteins known as the S-layer.

  • annual review
    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint.

    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint. Jun 1, 2018

    In all cells derived from animals, plants, fungi and protozoa a single protein called UGGT acts as a quality control checkpoint that inspects secreted glycoproteins.

  • annual review
    Insights into the mechanism of colistin resistance from crystal structures of MCR-1

    Insights into the mechanism of colistin resistance from crystal structures of MCR-1 Jun 1, 2018

    Gram-negative bacteria that are extensively resistant to multiple antibiotics are an ever-increasing global threat. Colistin is an antibiotic used as the last line of defence against highly resistant Gram-negative bacteria. However, in recent years bacteria have emerged with resistance to this crucial antibiotic.

  • annual review
    How human endoglin captures its ligand BMP9

    How human endoglin captures its ligand BMP9 Jun 1, 2018

    Endoglin (ENG)/CD105 is a mammalian glycoprotein that is found in the membranes of cells that line blood vessels. It is essential for healthy heart development and blood vessel growth, but conversely it is also involved in preeclampsia and can help tumours establish their blood supply.

Robert Rambo, Science Group Leader

The Soft Condensed Matter (SCM) Group provides the infrared (IR) and Circular Dichroism (CD) microspectroscopy and both Small and Wide Angle X-ray Scattering (SAXS and WAXS) capabilities of Diamond. The group comprises of four beamlines: High Throughput SAXS (B21), the Multimode Infrared Imaging And Microspectroscopy (MIRIAM) beamline (B22), SAXS and Diffraction (I22) and the CD beamline (B23). This unique portfolio of beamlines can analyse a range of samples that include two-dimensional thin films (photovoltaics), living mammalian cells, three-dimensional matrices (e.g. metal-organic frameworks, gels and waxes) and nano-particles in non-crystalline states.

  • annual review
    Cancer cells hijack human body systems in order to spread

    Cancer cells hijack human body systems in order to spread Aug 9, 2019

    Acute myeloid leukaemia (AML) is a rapid and often fatal disease. The disease originates in the body’s system for producing white blood cells, where diseased AML cells (in common with many other types of cancer) will interfere with healthy human cytotoxic lymphoid cells, the body’s natural defence system against cancerous cells.

  • annual review
    A step towards earlier detection of multiple sclerosis

    A step towards earlier detection of multiple sclerosis Aug 9, 2019

    Using Diamond Light Source’s Small Angle Scattering & Diffraction beamline (I22), I911-SAXS at MAX IV Laboratory, SWING at SOLEIL synchrotron, and P12 at EMBL BioSAXS, a team of researchers from Tel Aviv University and the Technion-Israel Institute of Technology mapped, for the first time, the delicate and complicated force balance between the myelin sheath constituents and their effect on the myelin structure.

  • annual review
    A novel dynamic flow system for chemical analysis of live biological cells

    A novel dynamic flow system for chemical analysis of live biological cells Aug 9, 2019

    Analysing cells on a cell-by-cell basis using infrared microspectroscopy can reveal important biochemical information, providing insight into diseases, and drug-cell interactions. However, for visible and infrared microscopy, the cells have to be preserved and dried; also, water is a strong infrared absorber and obscures the spectrum of the cells under investigation.

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