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  1. Diamond Light Source
  2. News and Literature
  3. Annual Review
  4. Diamond Annual Review 2018
  5. Science Group Updates
  6. Crystallography Group

Crystallography Group

  • annual review
    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist

    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist Jun 1, 2018

    To design such small molecules, a detailed map of the interactions between GLP-1 and its receptor was needed.

  • annual review
    Structural insights into the mechanism of bacterial ABC transporters

    Structural insights into the mechanism of bacterial ABC transporters Jun 1, 2018

    Bacteria utilise ATP-binding cassette (ABC) transporters to import nutrients and detoxify themselves. These transporters have been shown to exist in wide open conformations that permit the access of many substrates in the binding pocket.

  • annual review
    Structure of the surface layer surrounding Caulobacter crescentus bacteria

    Structure of the surface layer surrounding Caulobacter crescentus bacteria Jun 1, 2018

    Many types of single-celled microorganisms such as bacteria are covered with a protective outer layer of proteins known as the S-layer.

  • annual review
    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint.

    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint. Jun 1, 2018

    In all cells derived from animals, plants, fungi and protozoa a single protein called UGGT acts as a quality control checkpoint that inspects secreted glycoproteins.

  • annual review
    Insights into the mechanism of colistin resistance from crystal structures of MCR-1

    Insights into the mechanism of colistin resistance from crystal structures of MCR-1 Jun 1, 2018

    Gram-negative bacteria that are extensively resistant to multiple antibiotics are an ever-increasing global threat. Colistin is an antibiotic used as the last line of defence against highly resistant Gram-negative bacteria. However, in recent years bacteria have emerged with resistance to this crucial antibiotic.

  • annual review
    How human endoglin captures its ligand BMP9

    How human endoglin captures its ligand BMP9 Jun 1, 2018

    Endoglin (ENG)/CD105 is a mammalian glycoprotein that is found in the membranes of cells that line blood vessels. It is essential for healthy heart development and blood vessel growth, but conversely it is also involved in preeclampsia and can help tumours establish their blood supply.

Update

The Crystallography Science Group comprises beamlines I11, I15, I15-1, and I19, members of the former Engineering & Environment and the Materials Villages. The reorganisation of the beamlines into Science Groups will enhance the collaboration across Diamond. Furthermore, the technical and scientific expertise within the Crystallography Science Group can be fully exploited to provide the basis for future development and pioneering experiments. Read more ...

  • annual review
    Putting the squeeze on Re<sup>IV</sup>

    Putting the squeeze on ReIV Jun 1, 2018

    Materials that have long range magnetic order are fundamental to modern technologies, including data storage devices, space research, cancer therapy and biomedical imaging techniques. Future miniaturisation of these components depends on designing molecules that behave in the same way as larger magnets, and to do this we need an improved understanding of the connection between molecular structures and their resulting properties. Although high-temperature- and high-magnetic-field-based ...

  • annual review
    Metal Organic Framework Liquids and Glass: Moving Away From the Ordered Domain

    Metal Organic Framework Liquids and Glass: Moving Away From the Ordered Domain Jun 1, 2018

    Building on previous work conducted at Diamond, researchers have used X-ray Pair Distribution Function (XPDF) on the I15-1 beamline to probe the structure of a Metal Organic Framework (MOF) in its glassy state, from which they inferred the structure of its liquid form. MOFs are crystalline materials, which are receiving a lot of interest due to their porous nature, which allows them to accommodate guest molecules within their structure. Potential applications include drug delivery, ...

  • annual review
    Using high temperature and pressure to form novel materials

    Using high temperature and pressure to form novel materials Jun 1, 2018

    Chemistry drastically changes at very high pressures, allowing exotic types of chemical interactions leading to the formation of novel materials. For mixtures of iron (Fe) with a significant amount of nitrogen (N), theoretical calculations suggested that new Fe-N compounds could be synthesised at high pressures, and are expected to have enhanced properties such as increased hardness, superconductivity, or the ability to act as a catalyst. A team of researchers used I15 to carry out this ...

  • annual review
    Moving towards renewable raw material sources

    Moving towards renewable raw material sources Jun 1, 2018

    The world currently relies on coal, oil and gas, not only for fuel but also as raw materials for the production of chemicals. With reserves of these fossil fuels running out, and a growing awareness of the CO2 pollution their use causes, it is becoming increasingly important to develop sustainable carbon sources.

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