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  • Integrated Structural Biology
    • Macromolecular Crystallography (MX)
      • User Guide
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      • MX Beamlines
      • Access Modes
      • Meet the MX team
      • MX case studies
    • Crystallisation Services
    • Fragment Screening - XChem
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  • Spectroscopy
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  • High Resolution TEM (ePSIC)
  • Hard X-ray Nanoprobe

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  1. Industry Services
  2. Techniques Available
  3. Integrated Structural Biology
  4. Macromolecular Crystallography (MX)
  5. MX Beamlines

MX Beamlines

Diamond's offers a portfolio of highly specialised MX beamlines to suit a wide range of experiments. We follow a programme of continuous upgrades and additions to our portfolio, to maintain our world-leading position for structural biology research.

Beamline specifications are updated frequently as upgrades are introduced onto the beamlines, so check for our very latest specifications. Click on the beamline links below for further details.

  • I03 High throughput
  • I04 Microfocus
  • I04-1 Fixed wavelength
  • I23 Long-Wavelength
  • I24 Microfocus
  • VMXi In-situ
  • VMXm Nanofocus

I03I03 is a high throughput tuneable beamline. Its containment infrastructure also allows experiments on biological agents in Hazard Groups 2 and 3.

Best for: 

  • Standard data collection
  • Experimental SAD and MAD phasing
  • Unattended data collection (UDC) experiments
  • Experiments using Hazard Groups 2/3 biological samples

Key benefits:

  • High photon flux
  • Fast data collection, up to 24 samples per hour with UDC
  • Fully automated data collection with X-ray centring (UDC) 
  • Next generation Eiger2 detector

Find out more

I04I04 is a high throughput tuneable beamline with a variable beam size from 5 to 100 microns.  

Best for:

  • Standard data collection
  • Experimental SAD and MAD phasing
  • Unattended data collection (UDC)
  • Small or disordered crystals
  • Samples in LCP

Key benefits:

  • Micro focus beam
  • Fast data collection, up to 24 samples per hour with UDC
  • Fully automated data collection with X-ray centring (UDC)
  • Next generation Eiger2 detector

Find out more

I04-1 is a high throughput fixed wavelength beamline associated with the XChem platform.

Best for:

  • Standard data collection
  • Experimental SAD phasing (optimal for Br, good for Se)
  • Fragment screening (XChem)

Key Benefits:

  • Fast and fully automated data collection, up to 32 samples per hour

Find out more

I23I23 is a long-wavelength tuneable beamline dedicated to phasing experiments. The whole endstation, including I23 bespoke Pilatus detector, is under vacuum to minimise absorption and scattering effects.

Best for: 

  • Experimental phasing on native samples (i.e. S and P)
  • Phasing of large macrolecular complexes
  • Ion binding characterisation (e.g. Ca, K or Cl)

Key benefits:

  • Operational wavelength range from 1.5 to 4 Å
  • Access to the absorption edges of physiologically important elements

Find out more

 

I24I24 is a high throughput tuneable beamline with a variable microfocus beam from 5 to 50 microns. The beamline has a dual goniometer endstation allowing for both cryo and in situ modes of data collection.

Best for:

  • Standard data collection
  • Experimental SAD and MAD phasing
  • Small and disordered samples
  • Samples in LCP
  • Serial synchrotron crystallography (SSX)

Key Benefits:

  • Microfocus beam
  • High photon flux density
  • Serial and Fixed target crystallography
  • Eiger2 CdTe detector for high energy microfocus data collection

Find out more

 

VMXiThis Versatile Macromolecular Crystallography in situ (VMXi) beamline is an entirely automated facility for characterisation of, and data collection directly from, crystallisation experiments in situ.

Best for: 

  • Characterisation of crystallisation experiments
  • In situ room temperature data collection

Key Benefits: 

  • Experiments carried out without manipulation of individual crystals
  • Provides feedback on the crystal quality and diffraction
  • Structural data collected at near physiological conditions
  • Fully automated

Find out more

 

 

 

 

VMXm

VMXm is a micro/nanofocus MX beamline aimed at atomic structure determination in cases where the production of significant quantities of protein material and crystals is problematic. 

Best for:

  • Atomic structure determination in cases where the production of significant quantities of protein material and crystals is problematic
  • Very small crystals
  • Experimental SAD and MAD phasing

Benefits:

  • < 500 nm beam size
  • X-ray energies from 7 - 25 keV
  • In vacuum sample environment

Find out more

 

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