MX Beamlines

I03 is a high throughput tuneable beamline. Its containment infrastructure also allows experiments on biological agents in Hazard Groups 2 and 3.

Best for: 

• Standard data collection
• Experimental SAD and MAD phasing
• Unattended data collection (UDC) experiments
• Experiments using Hazard Groups 2/3 biological samples

Key benefits:

• High photon flux
• Fast data collection, up to 24 samples per hour with UDC
• Fully automated data collection with X-ray centring (UDC) 
• Next generation Eiger2 detector

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I04 is a high throughput tuneable beamline with a variable beam size from 5 to 100 microns.  

Best for:

• Standard data collection
• Experimental SAD and MAD phasing
• Unattended data collection (UDC)
• Small or disordered crystals
• Samples in LCP

Key benefits:

• Micro focus beam
• Fast data collection, up to 24 samples per hour with UDC
• Fully automated data collection with X-ray centring (UDC)
• Next generation Eiger2 detector

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I04-1 is a high throughput fixed wavelength beamline associated with the XChem platform.

Best for:

• Standard data collection
• Experimental SAD phasing (optimal for Br, good for Se)
• Fragment screening (XChem)

Key Benefits:

• Fast and fully automated data collection, up to 32 samples per hour

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I23 is a long-wavelength tuneable beamline dedicated to phasing experiments. The whole endstation, including I23 bespoke Pilatus detector, is under vacuum to minimise absorption and scattering effects.

Best for: 

• Experimental phasing on native samples (i.e. S and P)
• Phasing of large macrolecular complexes
• Ion binding characterisation (e.g. Ca, K or Cl)

Key benefits:

• Operational wavelength range from 1.5 to 4 Å
• Access to the absorption edges of physiologically important elements

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I24 is a high throughput tuneable beamline with a variable microfocus beam from 5 to 50 microns. The beamline has a dual goniometer endstation allowing for both cryo and in situ modes of data collection.

Best for:

• Standard data collection
• Experimental SAD and MAD phasing
• Small and disordered samples
• Samples in LCP
• Serial synchrotron crystallography (SSX)

Key Benefits:

• Microfocus beam
• High photon flux density
• Serial and Fixed target crystallography
• Eiger2 CdTe detector for high energy microfocus data collection

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This Versatile Macromolecular Crystallography in situ (VMXi) beamline is an entirely automated facility for characterisation of, and data collection directly from, crystallisation experiments in situ.

Best for: 

• Characterisation of crystallisation experiments
• In situ room temperature data collection

Key Benefits: 

• Experiments carried out without manipulation of individual crystals
• Provides feedback on the crystal quality and diffraction
• Structural data collected at near physiological conditions
• Fully automated

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VMXm is a micro/nanofocus MX beamline aimed at atomic structure determination in cases where the production of significant quantities of protein material and crystals is problematic. 

Best for:

• Atomic structure determination in cases where the production of significant quantities of protein material and crystals is problematic
• Very small crystals
• Experimental SAD and MAD phasing

Benefits:

• < 500 nm beam size
• X-ray energies from 7 - 25 keV
• In vacuum sample environment

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