Fragment-based screening is now well-established as a powerful approach to early drug ("lead") discovery.
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The MiniFrags, designed by Astex, are a set of small molecules representing the minimal pharmacophores able to capture the maximum amount of interactions in a protein. Whilst this library is available, the soaking conditions are still under evaluation. Screens have so far been conducted at 1M in DMSO.
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SMILES:
O'Reilly, M., et al. Crystallographic screening using ultra-low molecular-weight ligands to guide drug design. Drug Discovery Today, (5) 1081-1086 (2019) (link to paper)
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Macromolecular Crystallography
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy