Symposium in Membrane Protein Crystallization

Sep 27.

Symposium in Membrane Protein Crystallization

The aim of this symposium is to address the recent advances in membrane protein crystallization

Date
27/09/20122012-09-27
Location
Research Complex at Harwell – Harwell Campus
Membrane proteins are important pharmaceutical targets as they are associated with many diseases. The knowledge of their atomic structure it is critical in drug discovery and thus to the well-being of our global society. X-ray crystallography is the common method of choice to obtain structural information at atomic level. However, crystallization of well ordered membrane protein crystals for X-ray diffraction studies remains a challenge. The aim of this symposium is to address the recent advances in membrane protein crystallization
 

Event details

Organizer:
Isabel Moraes (Diamond-MPL)
Momi Iwata    (Diamond-MPL)
 
Venue:  
Research Complex at Harwell – Harwell Campus
 
Fees:
£50 Academia
£150 Industry

Programme

    Symposium in Membrane Protein Crystallization
9:45 - 10:15 arrival/registration
10:15 - 10:30 welcome
Session 1 Chair: Prof. Steve Mathews - Imperial College London
10:30 -11:00 Introduction to Membrane Protein Crystallization
Isabel Moraes - Diamond - MPL
11:00 -11:30 Stabilising Membrane Protein Samples for Crystallization
Paul Thaw and Jeanette Hobbs - Molecular Dimensions
11:30 - 12:00 lipidic Cubic Phase Technologies for Membrane Protein Structural Studies 
Vadim Cherezov - The Scripps Research Institute - USA 
12:00 - 12:30 Membrane Protein Nano and Macro Crystallization using Lipidic Sponge Phases
Linda Johansson - University of Gothenburg - Sweden
12:30 - 13:30 lunch
Session 2 Chair: Prof. Thomas Sorensen - Diamond Light Source
13:30 - 14:00 The Use of Bicelles in Membrane Protein Crystallization
Jeff Abramson - University of California, Los Angeles - USA
14:00 - 14:30 Current Trends in Alpha Helical Membrane Protein crystallization - The Rationale Behind MemGold, MemGold2 and MemAdvantage Screens
Simon Newstead - University of Oxford
14:30 - 15:00 Advances in Automated Imaging and Liquid Handling to Support Membrane Protein Research
Olivia Sleator - Rigaku
15:00 - 15:30 Crystallizing GPCRs for Drug Discovery
João Dias - Heptares
15:30 - 16:00 Break
session 3 Chair: Dr Alex Cameron - Imperial College London
16:00 - 16:30 Imaging Protein Crystals with Ultrafast Lasers
Ellen Gualtieri - Formulatrix
16:30 - 17:00 Exploiting Microfocused X-rays for Challenging Problems in MX
Robin Owen - Diamond Light Source
17:00 - 17:30 BLEND - The systematic Scaling and Merging of Multiple Datasets in Macromolecular crystallography
James Foadi - Diamond - MPL
17:30 Closing remarks