A combination of soft X-ray and laser light sources offer 3D high content information on the native state of the cellular environment Chidinma A. Okolo, Thomas M. Fish, Kamal L. Nahas, Archana C. Jadhav, Nina Vyas, Adam Taylor, Maria Harkiolaki
Journal Of Physics: Conference Series, 2380 Dec 2022 DOI: 10.1088/1742-6596/2380/1/012042 Synchrotron radiation and laser light microscopy partnership for the study of biological systems: the case of Soft X-ray Tomography and structured illumination microscopy at cryogenic temperatures Maria Harkiolaki, Nina Vyas, Claire Pizzey, Thomas Fish, Archana Jadhav, Kamal Nahas, Chidinma Okolo
Microscopy & Microanalysis 2022: B04 - Correlative And Multimodal Microscopy And Analysis , Aug 2022 DOI: 10.1017/S1431927622005463 How does the herpes virus hijack our cells? Cryo-SXT can show us Diamond Light Source
Aug 2022 Science Highlight B24-Cryo Soft X-ray Tomography
Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection Kamal Nahas, Viv Connor, Katharina M. Scherer, Clemens F. Kaminski, Maria Harkiolaki, Colin M. Crump, Stephen C. Graham
Plos Pathogens, 18 Jul 2022 DOI: 10.1371/journal.ppat.1010629 Contour : A semi-automated segmentation and quantitation tool for cryo-soft-X-ray tomography Kamal Nahas, João Ferreira Fernandes, Nina Vyas, Colin Crump, Stephen Graham, Maria Harkiolaki
Biological Imaging, 2 May 2022 DOI: 10.1017/S2633903X22000046 SuRVoS 2: accelerating annotation and segmentation for large volumetric bioimage workflows across modalities and scales Avery Pennington, Oliver N. F. King, Win Min Tun, Elaine M. L. Ho, Imanol Luengo, Michele C. Darrow, Mark Basham
Frontiers In Cell And Developmental Biology, 10 Apr 2022 DOI: 10.3389/fcell.2022.842342 Journal Paper B24-Cryo Soft X-ray Tomography I13-2-Diamond Manchester Imaging Krios I-Titan Krios I at Diamond open access Epitope length variants balance protective immune responses and viral escape in HIV-1 infection Phillip Pymm, Stefan Tenzer, Edmund Wee, Mirjana Weimershaus, Anne Burgevin, Simon Kollnberger, Jan Gerstoft, Tracy M. Josephs, Kristin Ladell, James E. Mclaren, Victor Appay, David A. Price, Lars Fugger, John I. Bell, Hansjörg Schild, Peter Van Endert, Maria Harkiolaki, Astrid K. N. Iversen
Cell Reports, 38 Mar 2022 DOI: 10.1016/j.celrep.2022.110449 Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes Hsin-Fang Chang, Claudia Schirra, Momchil Ninov, Ulrike Hahn, Keerthana Ravichandran, Elmar Krause, Ute Becherer, Stefan Balint, Maria Harkiolaki, Henning Urlaub, Salvatore Valitutti, Cosima T. Baldari, Michael L. Dustin, Reinhard Jahn, Jens Rettig
Nature Communications, 13 Feb 2022 DOI: 10.1038/s41467-022-28596-y