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“Type 1 diabetes is a result of the body’s own immune system attacking and destroying the cells in the pancreas that manufacture the hormone insulin. Insulin controls blood sugar levels and a lack of insulin is fatal if untreated. The mechanism by which the body attacks its own insulin producing cells in the pancreas is not fully understood. Our findings show how killer T-cells might play an important role in autoimmune diseases like diabetes and we’ve secured the first ever glimpse of the mechanism by which killer T-cells can attack our own body cells to cause disease.”Professor Andy Sewell, School of Medicine, Cardiff University
Diabetes describes diseases where a person has high blood sugar. Treatment of diabetes and its complications represents a major health burden and accounts for over 10% of the National Health Service’s annual budget.
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“Structural basis of human b-cell killing by preproinsulin-specific CD8+ T-cells in type 1 diabetes” was published in the journal, Nature Immunology (15/01/12). “A single autoimmune T-cell receptor recognises over a million different peptides” was published in the Journal of Biological Chemistry (06/01/12)
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