Following the emergence of the new coronavirus SARS-CoV-2 in late 2019 which quickly developed into a pandemic, the race soon began to discover more about the virus and prevent its spread.
Building on the knowledge gained from the SARS outbreak in 2003, it is hoped that by studying the structure of the proteins in SARS-CoV-2 scientists will identify potential lead compounds and develop therapies to prevent viral infection and replication.
In the past two decades, fragment based drug discovery has emerged as a powerful method to discover and develop new drugs. Such strategy relies on the identification of low molecular weight compounds that bind weakly to a target. The structural information gained on fragment-target complexes provides an excellent starting point for the development of potent and selective drugs.Read more...
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