Manikandan Karuppasamy

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Industrial Liaison Scientist, Cryo-Electron Microscopy

Email: industry@diamond.ac.uk
Tel: +44 (0)1235 394195

Manikandan Karuppasamy joined eBIC for Industry’s team of cryo-EM scientists early in 2022. He assists industrial clients in screening, collecting high-resolution single-particle cryo-EM data, and solving difficult structures.

He has a background in structural biology, having worked in academia to understand the biological functions of several macromolecular complexes using both crystallography and cryo-EM.

He gained his PhD in protein crystallography at the Indian Institute of Science in Bangalore where he identified the molecular factors responsible for the adaptation of temperature and salt stability of xylanases in extreme environments from their atomic structures.

Following this, he joined EMBL-Hamburg as a Humboldt Research Fellow and deciphered X-ray crystal structures of Leucine biosynthesis pathway enzymes of Mycobacterium tuberculosis before moving to EMBL-Grenoble to apply cryo-EM techniques to solve structures of pharmaceutically important macromolecular complexes.

His research interests centre on solving challenging smaller pharmaceutical targets and membrane proteins by cryo-EM and he has a keen interest in contributing to method development for faster screening of grids for high-resolution data collection.

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