___________________________________
Industrial Liaison Group:
Tel: +44 (0) 1235 778797
E-mail: industry@diamond.ac.uk
Nitrogen-containing heterocyclic compounds form the basis of many drugs due to their useful physiological and pharmacological properties, including the ability to easily form hydrogen bonds with biological targets; currently, 75% of all FDA-approved drugs fall into this category.
A quinoline or isoquinoline moiety is a key building block for many of these drugs, due to its ability to inhibit cell growth. Functionalised quinolinium and isoquinolinium salt moieties are key to the function of many treatments for conditions such as cancer, HIV, malaria, and diabetes.
In a recent study at Diamond, we see scientists from AstraZeneca study a novel method for the reductive functionalisation of quinolinium and isoquinolinium salts using an extended range of electrophiles. The mild reaction conditions include the use of a low-loaded rhodium catalyst and an inexpensive formic acid as the terminal reductant. The team used in situ small molecule single crystal diffraction to identify the species formed.
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
Copyright © 2022 Diamond Light Source
Diamond Light Source Ltd
Diamond House
Harwell Science & Innovation Campus
Didcot
Oxfordshire
OX11 0DE
Diamond Light Source® and the Diamond logo are registered trademarks of Diamond Light Source Ltd
Registered in England and Wales at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom. Company number: 4375679. VAT number: 287 461 957. Economic Operators Registration and Identification (EORI) number: GB287461957003.
Industrial Liaison Office
