___________________________________
Industrial Liaison Group:
Tel: +44 (0) 1235 778797
E-mail: industry@diamond.ac.uk
Blocking the process of apoptosis (which results in cell death) is a way in which cancer cells are able to survive and proliferate. Inhibitors of key pro-survival proteins (of which BCL-2, BCL-xL, MCL-1 have been identified as key targets) have long been recognised as providing an effective therapeutic approach to eliminate cancer cells.
In a study using Macromolecular Crystallography at Diamond, a team of researchers from Vernalis explore the effect of core replacement on S64315, a selective MCL-1 inhibitor.
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
Copyright © 2022 Diamond Light Source
Diamond Light Source Ltd
Diamond House
Harwell Science & Innovation Campus
Didcot
Oxfordshire
OX11 0DE
Diamond Light Source® and the Diamond logo are registered trademarks of Diamond Light Source Ltd
Registered in England and Wales at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom. Company number: 4375679. VAT number: 287 461 957. Economic Operators Registration and Identification (EORI) number: GB287461957003.
Industrial Liaison Office
