This very large Mpro screening experiment yielded an exceptionally rich set information, with very extensive opportunities for fragment growing and merging; we are thus anxious to ensure the high quality data is effective as possible at seeding anti-COVID-19 efforts around the world.
On our end, we have initiated efforts to develop these hits into compounds potent enough to have an impact:
Beyond that, we are now joining forces with a new and urgent, fully open initiative to drive these results as far towards clinical impact as possible, by crowdsourcing molecule design from medicinal chemists worldwide, with the hope of converting these into physical compounds and assays.
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