Beamline VMXm - sub-micron crystallography

VMXm is a micro/nanofocus Macromolecular Crystallography (MX) beamline aimed at atomic structure determination in cases where the production of significant quantities of protein material and crystals is problematic. Indeed this is the case for many challenging protein complexes and medically important macromolecules that yield only very small crystals.

The X-ray beam size on VMXm will be less that 0.5 microns and with the use of novel X-ray optics and electron beam imaging methods we will be able to precisely align the tiniest protein crystals into this X-ray beam, in vacuo, and measure X-ray diffraction data from them.

The ability to tune the X-ray energy will allow us to obtain additional information from heavy atoms with in the macromolecules to aid in structure determination by multicrystal SAD or MAD methods.

VMXm is now accepting applications for use of commissioning beamtime (as of 2022). During this period beamline staff will be working to optimize the performance of VMXm and will work closely with users to obtain the best possible results from user samples within the current operating envelope.

 A Sample Preparation Pipeline for Microcrystals at the VMXm Beamline