Novel lipid-interaction motifs within the C-terminal domain of Septin10 from Schistosoma mansoni Italo A. Cavini, Marina G. Fontes, Ana Eliza Zeraik, Jose L. S. Lopes, Ana Paula U. Araujo
Biochimica Et Biophysica Acta (bba) - Biomembranes, 1866 Oct 2024 DOI: 10.1016/j.bbamem.2024.184371 Ending the cold chain: novel hydrogel set to improve access to vital medicines Diamond Light Source
Oct 2024 Science Highlight B21-High Throughput SAXS I22-Small angle scattering & Diffraction
Mutations in the N-domain of aryl hydrocarbon receptor interacting protein affect interactions with heat shock protein 90β and phosphodiesterase 4A5 Marita Vella, Iain W. Manfield, Brandon C. Seychell, Chi H. Trinh, Robert Rambo, G. Nasir Khan, Josanne Vassallo, Therese Hunter, Gary J. Hunter
Biochimie, 272 Sept 2024 DOI: 10.1016/j.biochi.2024.09.005 Better together: Monolithic halide perovskite@metal-organic framework composites Elena Avila, Hayden Salway, Edoardo Ruggeri, Ceren Çamur, Nakul Rampal, Tiarnan A. S. Doherty, Oliver D. I. Moseley, Samuel D. Stranks, David Fairen-Jimenez, Miguel Anaya
Matter, 48 Sept 2024 DOI: 10.1016/j.matt.2024.08.022 Journal Paper B21-High Throughput SAXS labSAXS-Offline SAXS and Sample Environment Development open access Evolutionary and molecular basis of ADP-ribosylation reversal by zinc-dependent macrodomains Antonio Ariza, Qiang Liu, Nathan Cowieson, Ivan Ahel, Dmitri V. Filippov, Johannes Gregor Matthias Rack
Journal Of Biological Chemistry, 20 Sept 2024 DOI: 10.1016/j.jbc.2024.107770 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access Metal-free ring-opening polymerization for the synthesis of biocompatible star-shaped block copolymers with controllable architecture Wanwanut Chueasupcharoen, Puttinan Meepowpan, Kiattikhun Manokruang, Montira Sriyai, Chawan Manaspon, Brian J. Tighe, Matthew J. Derry, Paul D. Topham, Winita Punyodom
European Polymer Journal, 8 Sept 2024 DOI: 10.1016/j.eurpolymj.2024.113471 BRCA2 stabilises RAD51 and DMC1 nucleoprotein filaments through a conserved interaction mode James M. Dunce, Owen R. Davies
Nature Communications, 15 Sept 2024 DOI: 10.1038/s41467-024-52699-3 Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access The affinity towards the hydrophobic region of biomimicking bacterial membranes drives the antimicrobial activity of EFV12 peptide from Lactobacillus gasseri gut microbiota Giuseppe Vitiello, Alessandra Luchini, Michela Di Napoli, Noemi Gallucci, Domenico Cavasso, Alexandros Koutsioubas, Mario Varcamonti, Anna Zanfardino, Giovanna Fragneto, Luigi Paduano
Journal Of Molecular Liquids, 25 Sept 2024 DOI: 10.1016/j.molliq.2024.126086 An integrative characterisation of proline cis and trans conformers in a disordered peptide Alice J. Pettitt, Vaibhav Kumar Shukla, Angelo Miguel Figueiredo, Lydia S. Newton, Stephen Mccarthy, Alethea B. Tabor, Gabriella T. Heller, Christian D. Lorenz, Dennis Flemming Hansen
Biophysical Journal, Sept 2024 DOI: 10.1016/j.bpj.2024.09.028 The SCR-17 and SCR-18 glycans in human complement Factor H enhance its regulatory function Xin Gao, Hina Iqbal, Ding-Quan Yu, Jayesh Gor, Alun R. Coker, Stephen J. Perkins
Journal Of Biological Chemistry, 344 Aug 2024 DOI: 10.1016/j.jbc.2024.107624 Influence of chirality and sequence in lysine-rich lipopeptide biosurfactants and micellar model colloid systems Ian W. Hamley, Anindyasundar Adak, Valeria Castelletto
Nature Communications, 15 Aug 2024 DOI: 10.1038/s41467-024-51234-8 Understanding X-ray-induced isomerisation in photoswitchable surfactant assemblies Beatrice E. Jones, Camille Blayo, Jake L. Greenfield, Matthew J. Fuchter, Nathan P. Cowieson, Rachel C. Evans
Beilstein Journal Of Organic Chemistry, 20 Aug 2024 DOI: 10.3762/bjoc.20.176 MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombination Manickam Gurusaran, Jingjing Zhang, Kexin Zhang, Hiroki Shibuya, Owen R. Davies
Nature Communications, 15 Aug 2024 DOI: 10.1038/s41467-024-50920-x Journal Paper B21-High Throughput SAXS I04-Macromolecular Crystallography open access Minimal peptide sequences that undergo liquid–liquid phase separation via self-coacervation or complex coacervation with ATP Valeria Castelletto, Jani Seitsonen, Alice Pollitt, Ian W. Hamley
Biomacromolecules, 49 Jul 2024 DOI: 10.1021/acs.biomac.4c00738 Mechanical release of homogenous proteins from supramolecular gels Simona Bianco, Muhammad Hasan, Ashfaq Ahmad, Sarah-Jane Richards, Bart Dietrich, Matthew Wallace, Qiao Tang, Andrew J. Smith, Matthew I. Gibson, Dave Adams
Nature, 631 Jul 2024 DOI: 10.1038/s41586-024-07580-0 Journal Paper B21-High Throughput SAXS I22-Small angle scattering & Diffraction open access Developing an in situ LED irradiation system for small-angle X-ray scattering at B21, Diamond Light Source Beatrice E. Jones, Ann Fitzpatrick, Kieran Fowell, Charlotte J. C. Edwards-Gayle, Nikul Khunti, Katsuaki Inoue, Steven Daniels, Eugene Williams, Camille Blayo, Rachel C. Evans, Nathan Cowieson
Journal Of Synchrotron Radiation, 31 Jul 2024 DOI: 10.1107/S1600577524003205 Molecular basis for different substrate‐binding sites and chaperone functions of the BRICHOS domain Gefei Chen, Yu Wang, Zihan Zheng, Wangshu Jiang, Axel Leppert, Xueying Zhong, Anna Belorusova, Gregg Siegal, Caroline Jegerschold, Philip J. B. Koeck, Axel Abelein, Hans Hebert, Stefan D. Knight, Jan Johansson
Protein Science, 33 Jul 2024 DOI: 10.1002/pro.5063 Partitioning of an enzyme-polymer surfactant nanocomplex into lipid-rich cellular compartments drives in situ hydrolysis of organophosphates Benjamin M. Carter, Graham J. Day, William H. Zhang, Richard B. Sessions, Colin J. Jackson, Adam W. Perriman
Small, 259 Jul 2024 DOI: 10.1002/smll.202401982 Journal Paper B21-High Throughput SAXS B23-Circular Dichroism open access Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs Patrick E. Konold, Leonardo Monrroy, Alfredo Bellisario, Diogo Filipe, Patrick Adams, Roberto Alvarez, Richard Bean, Johan Bielecki, Szabolcs Bódizs, Gabriel Ducrocq, Helmut Grubmueller, Richard A. Kirian, Marco Kloos, Jayanath C. P. Koliyadu, Faisal H. M. Koua, Taru Larkiala, Romain Letrun, Fredrik Lindsten, Michael Maihöfer, Andrew Martin, Petra Mészáros, Jennifer Mutisya, Amke Nimmrich, Kenta Okamoto, Adam Round, Tokushi Sato, Joana Valerio, Daniel Westphal, August Wollter, Tej Varma Yenupuri, Tong You, Filipe Maia, Sebastian Westenhoff
Nature Methods, 17 Jul 2024 DOI: 10.1038/s41592-024-02344-0 The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes Oda C. Krokengen, Christine Touma, Anna Mularski, Aleksi Sutinen, Ryan Dunkel, Marie Ytterdal, Arne Raasakka, Haydyn D. T. Mertens, Adam Cohen Simonsen, Petri Kursula
Biochimica Et Biophysica Acta (bba) - Biomembranes, 79 Jul 2024 DOI: 10.1016/j.bbamem.2024.184368 Gonococcal mimitope vaccine candidate forms a beta-hairpin turn and binds hydrophobically to a therapeutic monoclonal antibody Peter T. Beernink, Cristina Di Carluccio, Roberta Marchetti, Linda Cerofolini, Sara Carillo, Alessandro Cangiano, Nathan Cowieson, Jonathan Bones, Antonio Molinaro, Luigi Paduano, Marco Fragai, Benjamin P. Beernink, Sunita Gulati, Jutamas Shaughnessy, Peter A. Rice, Sanjay Ram, Alba Silipo
Jacs Au, Jul 2024 DOI: 10.1021/jacsau.4c00359 Structural basis for Mis18 complex assembly and its implications for centromere maintenance Reshma Thamkachy, Bethan Medina-Pritchard, Sang Ho Park, Carla G. Chiodi, Juan Zou, Maria De La Torre-Barranco, Kazuma Shimanaka, Maria Alba Abad, Cristina Gallego Páramo, Regina Feederle, Emilija Ruksenaite, Patrick Heun, Owen R. Davies, Juri Rappsilber, Dina Schneidman-Duhovny, Uhn-Soo Cho, A. Arockia Jeyaprakash
Embo Reports, 21 Jul 2024 DOI: 10.1038/s44319-024-00183-w Cross-link of telechelic diacrylate polyethylene-glycol in peptide-based Fmoc-FF hydrogel matrices Elisabetta Rosa, Paolo Pellegrino, Mariafrancesca Cascione, Rosaria Rinaldi, Eliana Gianolio, Charlotte J. C. Edwards-Gayle, Ian W. Hamley, Giancarlo Morelli, Antonella Accardo, Carlo Diaferia
Acs Applied Polymer Materials, June 2024 DOI: 10.1021/acsapm.4c01059 A de novo designed coiled coil-based switch regulates the microtubule motor kinesin-1 Jessica A. Cross, William M. Dawson, Shivam R. Shukla, Johannes F. Weijman, Judith Mantell, Mark P. Dodding, Derek N. Woolfson
Nature Chemical Biology, 53 June 2024 DOI: 10.1038/s41589-024-01640-2 The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans Saima Rehman, Anna Katarina Antonovic, Ian E. Mcintire, Huaixin Zheng, Leanne Cleaver, Maria Baczynska, Carlton O. Adams, Theo Portlock, Katherine Richardson, Rosie Shaw, Alain Oregioni, Giulia Mastroianni, Sara B-M. Whittaker, Geoff Kelly, Christian D. Lorenz, Arianna Fornili, Nicholas P. Cianciotto, James A. Garnett
Nature Communications, 15 June 2024 DOI: 10.1038/s41467-024-49255-4 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography open access Development of a single‐domain antibody to target a G‐quadruplex located on the hepatitis B virus covalently closed circular DNA genome Gerardo B. Figueroa, Simmone D'Souza, Higor S. Pereira, Gunjan Vasudeva, Sara B. Figueroa, Zachary E. Robinson, Maulik D. Badmalia, Vanessa Meier‐stephenson, Jennifer A. Corcoran, Guido Van Marle, Yi Ni, Stephan Urban, Carla S. Coffin, Trushar R. Patel
Journal Of Medical Virology, 96 June 2024 DOI: 10.1002/jmv.29692 Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2 Abhishek Jamwal, Florent Colomb, Henry J. Mcsorley, Matthew K. Higgins
Nature Communications, 15 June 2024 DOI: 10.1038/s41467-024-49550-0 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access Exploring the use of a lipopeptide in dipalmitoylphosphatidylcholine monolayers for enhanced detection of glyphosate in aqueous environments Priscila S. Ferreira, Barbara B. Gerbelli, Ana C. H. Castro-Kochi, Bruna Cortez, Fabiola L. Castro, Jorge Cantero, Federico Iribarne, Ian W. Hamley, Wendel A. Alves
Langmuir, June 2024 DOI: 10.1021/acs.langmuir.4c01089 Rationally seeded computational protein design of ɑ-helical barrels Katherine I. Albanese, Rokas Petrenas, Fabio Pirro, Elise A. Naudin, Ufuk Borucu, William M. Dawson, D. Arne Scott, Graham. J. Leggett, Orion D. Weiner, Thomas A. A. Oliver, Derek N. Woolfson
Nature Chemical Biology, 53 June 2024 DOI: 10.1038/s41589-024-01642-0 Journal Paper B21-High Throughput SAXS I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Unravelling biochemical and structural features of Bacillus licheniformis GH5 mannanase using site-directed mutagenesis and high-resolution protein crystallography studies Lorenzo Briganti, Livia R. Manzine, Caio Cesar De Mello Capetti, Evandro Ares De Araújo, Vanessa De Oliveira Arnoldi Pellegrini, Francisco Eduardo Gontijo Guimaraes, Mario De Oliveira Neto, Igor Polikarpov
International Journal Of Biological Macromolecules, 87 June 2024 DOI: 10.1016/j.ijbiomac.2024.133182 Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling Samuel C. Griffiths, Jia Tan, Armin Wagner, Levi L. Blazer, Jarret J. Adams, Srisathya Srinivasan, Shayan Moghisaei, Sachdev S. Sidhu, Christian Siebold, Hsin-Yi Henry Ho
Elife, 13 May 2024 DOI: 10.7554/eLife.71980 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I23-Long wavelength MX open access Highlighting cubosome research at Diamond Diamond Light Source
May 2024 Science Highlight B21-High Throughput SAXS labSAXS-Offline SAXS and Sample Environment Development I22-Small angle scattering & Diffraction
Ordered hierarchical superlattice amplifies coated-CeO2 nanoparticles luminescence Noemi Gallucci, Marie-Sousai Appavou, Nathan P. Cowieson, Gerardino D'Errico, Rocco Di Girolamo, Stefano Lettieri, Filomena Sica, Giuseppe Vitiello, Luigi Paduano
Journal Of Colloid And Interface Science, 41 Apr 2024 DOI: 10.1016/j.jcis.2024.01.029 Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor Carlos Vela-Rodríguez, Chunsong Yang, Heli I. Alanen, Rebeka Eki, Tarek A. Abbas, Mirko M. Maksimainen, Tuomo Glumoff, Ramona Duman, Armin Wagner, Bryce M. Paschal, Lari Lehtio
Protein Science, 33 Apr 2024 DOI: 10.1002/pro.4945 Journal Paper B21-High Throughput SAXS I23-Long wavelength MX open access Using atomistic solution scattering modelling to elucidate the role of the Fc glycans in human IgG4 Valentina A. Spiteri, James Doutch, Robert P. Rambo, Jayesh S. Bhatt, Jayesh Gor, Paul A. Dalby, Stephen J. Perkins
Plos One, 19 Apr 2024 DOI: 10.1371/journal.pone.0300964 Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein Hasana Baber, Arega Aghajani, B. Harold Gallimore, Cassandra Bethel, James G. Hyatt, Elizabeth F.b. King, Helen P. Price, Marissa L. Maciej-Hulme, Suat Sari, Anja Winter
Biochimie, 6 Apr 2024 DOI: 10.1016/j.biochi.2024.03.017 Light-driven hexagonal-to-cubic phase switching in arylazopyrazole lyotropic liquid crystals Beatrice E. Jones, Jake L. Greenfield, Nathan Cowieson, Matthew J. Fuchter, Rachel C. Evans
Journal Of The American Chemical Society, Apr 2024 DOI: 10.1021/jacs.4c02709 Combining scattering experiments and colloid theory to characterize charge effects in concentrated antibody solutions Alessandro Gulotta, Marco Polimeni, Samuel Lenton, Charles G. Starr, Anna Stradner, Emanuela Zaccarelli, Peter Schurtenberger
Molecular Pharmaceutics, Apr 2024 DOI: 10.1021/acs.molpharmaceut.3c01023 Factor-dependent internal ribosome entry site and -1 programmed frameshifting signal in the bemisia-associated dicistrovirus 2 Yihang Chen, Subash Chapagain, Jodi Chien, Higor Sette Pereira, Trushar R. Patel, Alice K. Inoue-Nagata, Eric Jan
Viruses, 16 Apr 2024 DOI: 10.3390/v16050695 A multi-scale numerical approach to study monoclonal antibodies in solution Marco Polimeni, Emanuela Zaccarelli, Alessandro Gulotta, Mikael Lund, Anna Stradner, Peter Schurtenberger
Apl Bioengineering, 8 Mar 2024 DOI: 10.1063/5.0186642 Structural insights into the C-terminus of the histone-lysine N-methyltransferase NSD3 by small-angle X-ray scattering Benny D. Belviso, Yunpeng Shen, Benedetta Carrozzini, Masayo Morishita, Eric Di Luccio, Rocco Caliandro
Frontiers In Molecular Biosciences, 11 Mar 2024 DOI: 10.3389/fmolb.2024.1191246 Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres
Rsc Medicinal Chemistry, Feb 2024 DOI: 10.1039/D3MD00724C Investigation of supramolecular structures in various aqueous solutions of an amyloid forming peptide using small-angle X-ray scattering Ellen Brunzell, Kalle Sigfridsson, Lars Gedda, Katarina Edwards, L. Magnus Bergström
Soft Matter, 20 Feb 2024 DOI: 10.1039/D3SM01172K Block copolymer synthesis in ionic liquid via polymerisation-induced self-assembly: a convenient route to gel electrolytes Georgia L. Maitland, Mingyu Liu, Thomas J. Neal, James Hammerton, Yisong Han, Stephen D. Worrall, Paul D. Topham, Matthew J. Derry
Chemical Science, 22 Feb 2024 DOI: 10.1039/D3SC06717C From isolated polyelectrolytes to star-like assemblies: the role of sequence heterogeneity on the statistical structure of the intrinsically disordered neurofilament-low tail domain Mathar Kravikass, Gil Koren, Omar A. Saleh, Roy Beck
The European Physical Journal E, 47 Feb 2024 DOI: 10.1140/epje/s10189-024-00409-8 The pathogen-encoded signalling receptor Tir exploits host-like intrinsic disorder for infection Marta F. M. Vieira, Guillem Hernandez, Qiyun Zhong, Miguel Arbesú, Tiago Veloso, Tiago Gomes, Maria L. Martins, Hugo Monteiro, Carlos Frazão, Gad Frankel, Andreas Zanzoni, Tiago N. Cordeiro
Communications Biology, 7 Feb 2024 DOI: 10.1038/s42003-024-05856-9 Structural comparison of typical and atypical E2 pestivirus glycoproteins Hazel Aitkenhead, Christiane Riedel, Nathan Cowieson, Hans Tillmann Rümenapf, David I. Stuart, Kamel El Omari
Structure, 10 Jan 2024 DOI: 10.1016/j.str.2023.12.003 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I23-Long wavelength MX open access Self-assembly and antimicrobial activity of lipopeptides containing lysine-rich tripeptides Anindyasundar Adak, Valeria Castelletto, Ana De Sousa, Kimon-Andreas Karatzas, Callum Wilkinson, Nikul Khunti, Jani Seitsonen, Ian W. Hamley
Biomacromolecules, Jan 2024 DOI: 10.1021/acs.biomac.3c01184 Dynamic conformational changes of a tardigrade group-3 late embryogenesis abundant protein modulate membrane biophysical properties Xiao-Han Li, Conny W. H. Yu, Natalia Gomez-Navarro, Viktoriya Stancheva, Hongni Zhu, Andal Murthy, Michael Wozny, Ketan Malhotra, Christopher M. Johnson, Martin Blackledge, Balaji Santhanam, Wei Liu, Jinqing Huang, Stefan M. V. Freund, Elizabeth A. Miller, M. Madan Babu
Pnas Nexus, Jan 2024 DOI: 10.1093/pnasnexus/pgae006 Controlling aggregation of diketopyrrolopyrroles in water Valentina Gauci, Alex S. Loch, Daniel Mcdowall, Charlotte Edwards-Gayle, Dave J. Adams
Dyes And Pigments, 18 Jan 2024 DOI: 10.1016/j.dyepig.2024.111968 Structure-dynamics correlations in composite PF127-PEG-based hydrogels; cohesive/hydrophobic interactions determine phase and rheology and identify the role of micelle concentration in controlling 3D extrusion printability Krutika Singh, Jacek K. Wychowaniec, Charlotte J. C. Edwards-Gayle, Emmanuel G. Reynaud, Brian J. Rodriguez, Dermot F. Brougham
Journal Of Colloid And Interface Science, 25 Jan 2024 DOI: 10.1016/j.jcis.2023.12.151 Molecular mechanism of cellulose depolymerization by the two-domain BlCel9A enzyme from the glycoside hydrolase family 9 Evandro Ares De Araújo, Anelyse Abreu Cortez, Vanessa De Oliveira Arnoldi Pellegrini, Milena Moreira Vacilotto, Amanda Freitas Cruz, Paulo Ricardo Batista, Igor Polikarpov
Carbohydrate Polymers, 66 Jan 2024 DOI: 10.1016/j.carbpol.2023.121739 The crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion Manickam Gurusaran, Benedikte S. Erlandsen, Owen R. Davies
Communications Biology, 7 Jan 2024 DOI: 10.1038/s42003-024-05794-6 Journal Paper B21-High Throughput SAXS I24-Microfocus Macromolecular Crystallography open access 
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