These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
Design of novel mercapto-3-phenylpropanoyl dipeptides as dual angiotensin-converting enzyme C–domain-selective/neprilysin inhibitors Gyles E. Cozier, Lauren B. Coulson, Charles J. Eyermann, Gregory S. Basarab, Sylva L. Schwager, Kelly Chibale, Edward D. Sturrock, K. Ravi Acharya
Journal Of Medicinal Chemistry, Apr 2025 DOI: 10.1021/acs.jmedchem.5c00329 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access Microcrystallization and room-temperature serial crystallography structure of human cytochrome P450 3A4 Owens Uwangue, Johan Glerup, Andreas Dunge, Monika Bjelcic, Gabrielle Wehlander, Gisela Branden
Archives Of Biochemistry And Biophysics, 28 Apr 2025 DOI: 10.1016/j.abb.2025.110419 Comparative analysis of STP6 and STP10 unravels molecular selectivity in sugar transport proteins Camilla Gottlieb Andersen, Laust Bavnhøj, Søren Brag, Anastasiia Bohush, Adriana Chrenkova, Jan Heiner Driller, Bjorn Panyella Pedersen
Proceedings Of The National Academy Of Sciences, 122 Apr 2025 DOI: 10.1073/pnas.2417370122 Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography De novo design of parallel and antiparallel A3B3heterohexameric α-helical barrels Joel J. Chubb, Katherine I. Albanese, Alison Rodger, Derek N. Woolfson
Biochemistry, Apr 2025 DOI: 10.1021/acs.biochem.4c00584 Journal Paper I24-Microfocus Macromolecular Crystallography open access Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors Chiara Bosetti, Dionysis Kampasis, Shoshy A. Brinch, Albert Galera-Prat, Maria Karelou, Saurabh S. Dhakar, Juho Alaviuhkola, Jo Waaler, Lari Lehtio, Ioannis K. Kostakis
European Journal Of Medicinal Chemistry, 288 Apr 2025 DOI: 10.1016/j.ejmech.2025.117397 Journal Paper I24-Microfocus Macromolecular Crystallography open access Structure and catalytic mechanism of methylisocitrate lyase, a potential drug target against Coxiella burnetii William S. Stuart, Christopher H. Jenkins, Philip M. Ireland, Michail N. Isupov, Isobel H. Norville, Nicholas J. Harmer
Journal Of Biological Chemistry, 42 Apr 2025 DOI: 10.1016/j.jbc.2025.108517 Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Structural plasticity of Plasmodium falciparum plasmepsin X to accommodate binding of potent macrocyclic hydroxyethylamine inhibitors Chrislaine Withers-Martinez, Roger George, Roksana Ogrodowicz, Simone Kunzelmann, Andrew G. Purkiss, Svend Kjaer, Philip A. Walker, Vadims Kovada, Aigars Jirgensons, Michael J. Blackman
Journal Of Molecular Biology, 16 Mar 2025 DOI: 10.1016/j.jmb.2025.169062 Journal Paper I24-Microfocus Macromolecular Crystallography open access Structure of the outer membrane transporter fema and its role in the uptake of ferric dihydro-aeruginoic acid and ferric aeruginoic acid in Pseudomonas aeruginosa Virginie Will, Lucile Moynie, Elise Si Ahmed Charrier, Audrey Le Bas, Lauriane Kuhn, Florian Volck, Johana Chicher, Hava Aksoy, Morgan Madec, Cyril Antheaume, Gaëtan L. A. Mislin, Isabelle J. Schalk
Acs Chemical Biology, Mar 2025 DOI: 10.1021/acschembio.4c00820 Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography Crystal structure of ferric recombinant horseradish peroxidase Mst Luthfun Nesa, Suman K. Mandal, Christine Toelzer, Diana Humer, Peter C. E. Moody, Imre Berger, Oliver Spadiut, Emma L. Raven
Jbic Journal Of Biological Inorganic Chemistry, 2 Mar 2025 DOI: 10.1007/s00775-025-02103-2 Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access The conserved Spd-2/CEP192 domain adopts a unique protein fold to promote centrosome scaffold assembly Liuyi Hu, Alan Wainman, Antonina Andreeva, Muladili Apizi, Ines Alvarez-Rodrigo, Siu-Shing Wong, Saroj Saurya, Devon Sheppard, Matthew Cottee, Steven Johnson, Susan M. Lea, Jordan W. Raff, Mark Van Breugel, Zhe Feng
Science Advances, 11 Mar 2025 DOI: 10.1126/sciadv.adr5744 Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access Structure and unusual binding mechanism of the hyaluronan receptor LYVE-1 mediating leucocyte entry to lymphatics Fouzia Bano, Suneale Banerji, Tao Ni, Dixy E. Green, Kalila R. Cook, Iain W. Manfield, Paul L. Deangelis, Emanuele Paci, Martin Lepšík, Robert J. C. Gilbert, Ralf P. Richter, David G. Jackson
Nature Communications, 16 Mar 2025 DOI: 10.1038/s41467-025-57866-8 Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access Sequence rules for a long SPOP-binding degron required for protein ubiquitylation Linda Makhlouf, Mukul Mishra, Hannah Makhlouf, Iain Manfield, Luca Busino, Elton Zeqiraj
Biochemical Journal, Mar 2025 DOI: 10.1042/BCJ20253041 Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Reversible small molecule multivariant ras inhibitors display tunable affinity for the active and inactive forms of Ras Charles W. Parry, Francesca Pellicano, Alexander W. Schuettelkopf, Kim S. Beyer, Justin Bower, Amy Bryson, Kenneth Cameron, Nichole M. Cerutti, Jonathan P. Clark, Stuart C. Davidson, Keneth Davies, Martin J. Drysdale, Jeffrey Engelman, Anna Estevan-Barber, Andrea Gohlke, Christopher H. Gray, Daniel A. Guthy, Min Hong, Alana Hopkins, Luke D. Hutchinson, Jennifer Konczal, Michel Maira, Duncan Mcarthur, Mokdad Mezna, Heather Mckinnon, Ridvan Nepravishta, Nils Ostermann, Camila C. Pasquali, Katie Pollock, Angelo Pugliese, Nicholas Rooney, Niko Schmiedeberg, Paul Shaw, Camilo Velez-Vega, Christopher West, Ryan West, Frederic Zecri, John B. Taylor
Journal Of Medicinal Chemistry, 49 Mar 2025 DOI: 10.1021/acs.jmedchem.4c02929 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Solid-state NMR of membrane peptides and proteins in the lipid cubic phase Kiefer O. Ramberg, Coilin Boland, Hamed Kooshapur, Olivier Soubias, Maciej Wiktor, Chia-Ying Huang, Jonathan Bailey, Klaus Gawrisch, Martin Caffrey
Biophysical Journal, Mar 2025 DOI: 10.1016/j.bpj.2025.03.012 Journal Paper I24-Microfocus Macromolecular Crystallography open access Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel Mélanie Loiodice, Elodie Drula, Zak Mciver, Svetlana Antonyuk, Arnaud Basle, Marcelo Lima, Edwin A. Yates, Dominic P. Byrne, Jamie Coughlan, Andrew Leech, Shahram Mesdaghi, Daniel J. Rigden, Sophie Drouillard, William Helbert, Bernard Henrissat, Nicolas Terrapon, Gareth S. A. Wright, Marie Couturier, Alan Cartmell
Proceedings Of The National Academy Of Sciences, 122 Feb 2025 DOI: 10.1073/pnas.2421623122 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Virtual fragment screening for DNA repair inhibitors in vast chemical space Andreas Luttens, Duc Duy Vo, Emma R. Scaletti, Elisée Wiita, Ingrid Almlöf, Olov Wallner, Jonathan Davies, Sara Kosenina, Liuzhen Meng, Maeve Long, Oliver Mortusewicz, Geoffrey Masuyer, Flavio Ballante, Maurice Michel, Evert Homan, Martin Scobie, Christina Kalderén, Ulrika Warpman Berglund, Andrii V. Tarnovskiy, Dmytro S. Radchenko, Yurii S. Moroz, Jan Kihlberg, Pål Stenmark, Thomas Helleday, Jens Carlsson
Nature Communications, 16 Feb 2025 DOI: 10.1038/s41467-025-56893-9 Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Trojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics Shangwen Luo, Xin-Rong Li, Xiao-Tong Gong, Alexey Kulikovsky, Feng Qu, Konstantinos Beis, Konstantin Severinov, Svetlana Dubiley, Xinxin Feng, Shi-Hui Dong, Satish K. Nair
Proceedings Of The National Academy Of Sciences, 122 Jan 2025 DOI: 10.1073/pnas.2319483121 Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide Audrey Le Bas, Bradley R. Clarke, Tanisha Teelucksingh, Micah Lee, Kamel El Omari, Andrew M. Giltrap, Stephen A. Mcmahon, Hui Liu, John H. Beale, Vitaliy Mykhaylyk, Ramona Duman, Neil G. Paterson, Philip N. Ward, Peter J. Harrison, Miriam Weckener, Els Pardon, Jan Steyaert, Huanting Liu, Andrew Quigley, Benjamin G. Davis, Armin Wagner, Chris Whitfield, James H. Naismith
Open Biology, 15 Jan 2025 DOI: 10.1098/rsob.240310 Journal Paper I03-Macromolecular Crystallography I23-Long wavelength MX I24-Microfocus Macromolecular Crystallography Krios II-Titan Krios II at Diamond open access 
Macromolecular Crystallography
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy