Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04-1 Contact
Beamline Phone Number:
+44 (0) 1235 778979
Principal Beamline Scientist:
Frank von Delft
Tel: +44 (0) 1235 778997
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04-1 Fixed wavelength MX
Status: Operational
Beamsize: 60 x 50
Detector: Eiger2 XE 9M
Wavelength: 0.92Å (fixed)
Energy: 13.445 keV
Detector: Eiger2 XE 9M
Wavelength: 0.92Å (fixed)
Energy: 13.445 keV
These publications are based on data gathered on beamline I04-1. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
117 items found for 2015 [total: 1244]
Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome Bmc Biology, 13 Dec 2015 DOI: 10.1186/s12915-015-0136-2
Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family Nature Communications, 6 Dec 2015 DOI: 10.1038/ncomms10172
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin Nature Communications, 6 Dec 2015 DOI: 10.1038/ncomms10048
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain Chemical Science, Dec 2015 DOI: 10.1039/C5SC03115J
Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology- mediated end-joining pathway Structure, 23 (12) Dec 2015 DOI: 10.1016/j.str.2015.10.014
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Unraveling the B. pseudomalleiheptokinase WcbL: from structure to drug discovery Chemistry & Biology, 22 Dec 2015 DOI: 10.1016/j.chembiol.2015.10.015
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis Cancer Research, Dec 2015 DOI: 10.1158/0008-5472.CAN-15-0701-T
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Docking and linking of fragments to discover Jumonji histone demethylase inhibitors Journal Of Medicinal Chemistry, Dec 2015 DOI: 10.1021/acs.jmedchem.5b01527
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Structural studies of alpha2 macroglobulin from Limulus polyphemus Dec 2015
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Application of in situ diffraction in high-throughput structure determination platforms Methods In Molecular Biology, 1261 Nov 2015 DOI: 10.1007/978-1-4939-2230-7_13
Book Chapter I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The oxygenating constituent of 3,6-diketocamphane monooxygenase from the CAM plasmid of Pseudomonas putida: the first crystal structure of a type II Baeyer-Villiger monooxygenase Acta Crystallographica Section D Biological Crystallography, 71 (11) Nov 2015 DOI: 10.1107/S1399004715017939
The structure of a novel thermophilic esterase from the planctomycetes species, Thermogutta terrifontis reveals an open active site due to a minimal ‘cap’ domain Frontiers In Microbiology, 6 Nov 2015 DOI: 10.3389/fmicb.2015.01294
Structures of yeast peroxisomal [Delta]3,[Delta]2-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole Acta Crystallographica Section D Biological Crystallography, 71 Nov 2015 DOI: 10.1107/S139900471501559X
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities Nucleic Acids Research, Nov 2015 DOI: 10.1093/nar/gkv1256
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Crystal structure of the anion exchanger domain of human erythrocyte band 3 Science, 350 (6261) Nov 2015 DOI: 10.1126/science.aaa4335
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Mechanism of hydrogen activation by [NiFe] hydrogenases Nature Chemical Biology, Nov 2015 DOI: 10.1038/nchembio.1976
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Structural determinants of reductive terpene cyclization in iridoid biosynthesis Nature Chemical Biology, Nov 2015 DOI: 10.1038/nchembio.1955
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Structure of a Kunitz-type potato cathepsin D inhibitor Journal Of Structural Biology, 192 (3) Nov 2015 DOI: 10.1016/j.jsb.2015.10.020
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural basis for the binding of tryptophan-based motifs by δ-COP Proceedings Of The National Academy Of Sciences, Nov 2015 DOI: 10.1073/pnas.1506186112
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism Scientific Reports, 5 Nov 2015 DOI: 10.1038/srep17144
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Development of crystallographic techniques and their application to several protein targets Nov 2015
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystal structure of an antifungal osmotin-like protein from Calotropis procera and its effects on Fusarium solani spores, as revealed by atomic force microscopy: Insights into the mechanism of action Phytochemistry, Oct 2015 DOI: 10.1016/j.phytochem.2015.09.012
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structure of ATP synthase from Paracoccus denitrificans determined by X-ray crystallography at 4.0 Å resolution Proceedings Of The National Academy Of Sciences, Oct 2015 DOI: 10.1073/pnas.1517542112
Insights into collagen uptake by C-type mannose receptors from the crystal structure of Endo180 domains 1–4 Structure, Oct 2015 DOI: 10.1016/j.str.2015.09.004
Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex Acta Crystallographica Section F Structural Biology Communications, 71 Oct 2015 DOI: 10.1107/S2053230X1501643X
Three aromatic residues are required for electron transfer during iron mineralization in bacterioferritin Angewandte Chemie International Edition, Oct 2015 DOI: 10.1002/anie.201507486
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
High-resolution structures of Lactobacillus salivarius transketolase in the presence and absence of thiamine pyrophosphate Acta Crystallographica Section F Structural Biology Communications, 71 Oct 2015 DOI: 10.1107/S2053230X1501657X
The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer Scientific Reports, 5 Oct 2015 DOI: 10.1038/srep11234
Structural dissection of the maltodextrin disproportionation cycle of the arabidopsis plastidial enzyme DPE1 Journal Of Biological Chemistry, Oct 2015 DOI: 10.1074/jbc.M115.682245
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The crystal structure of pneumolysin at 2.0 Å resolution reveals the molecular packing of the pre-pore complex Scientific Reports, 5 Oct 2015 DOI: 10.1038/srep13293
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Extension of resolution and oligomerization-state studies of 2,4′-dihydroxyacetophenone dioxygenase from Acta Crystallographica Section F Structural Biology Communications, 71 Oct 2015 DOI: 10.1107/S2053230X15015873
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural and functional analysis of SleL, a peptidoglycan lysin involved in germination of Bacillus spores Proteins: Structure, Function, And Bioinformatics, 83 (10) Oct 2015 DOI: 10.1002/prot.24861
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Comprehensive characterization of the Published Kinase Inhibitor Set Nature Biotechnology, Oct 2015 DOI: 10.1038/nbt.3374
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis The Embo Journal, 34 Oct 2015 DOI: 10.15252/embj.201592337
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The active site of O-GlcNAc transferase imposes constraints on substrate sequence Nature Structural & Molecular Biology, 22 (9) Oct 2015 DOI: 10.1038/nsmb.3063
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers Antimicrobial Agents And Chemotherapy, Oct 2015 DOI: 10.1128/AAC.01335-15
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure and mechanism of a viral collagen prolyl hydroxylase Biochemistry, 54 (39) Oct 2015 DOI: 10.1021/acs.biochem.5b00789
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes Science, 350 Oct 2015 DOI: 10.1126/science.aac7365
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Iron binding to human heavy-chain ferritin Acta Crystallographica Section D Biological Crystallography, 71 Sept 2015 DOI: 10.1107/S1399004715013073
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
WONKA: objective novel complex analysis for ensembles of protein–ligand structures Journal Of Computer-Aided Molecular Design, Sept 2015 DOI: 10.1007/s10822-015-9866-z
Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors Medchemcomm, 6 (9) Sept 2015 DOI: 10.1039/C5MD00210A
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Streptococcus Pneumoniae NanC: structural insights into the specificity and mechanism of a sialidase that produces a sialidase inhibitor Journal Of Biological Chemistry, Sept 2015 DOI: 10.1074/jbc.M115.673632
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural basis for substrate and oxygen activation in homoprotocatechuate 2,3-dioxygenase: roles of conserved active site histidine 200 Biochemistry, 54 (34) Sept 2015 DOI: 10.1021/acs.biochem.5b00709
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structure and function of the Escherichia coli Tol-Pal stator protein TolR Journal Of Biological Chemistry, Sept 2015 DOI: 10.1074/jbc.M115.671586
Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design Human Molecular Genetics, 24 (20) Sept 2015 DOI: 10.1093/hmg/ddv280
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Identification and characterization of an irreversible inhibitor of CDK2 Chemistry & Biology, 22 (9) Sept 2015 DOI: 10.1016/j.chembiol.2015.07.018
Linkage of catalysis and 5′ end recognition in ribonuclease RNase J Nucleic Acids Research, 43 (16) Sept 2015 DOI: 10.1093/nar/gkv732
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain Plos One, 10 (7) Sept 2015 DOI: 10.1371/journal.pone.0132004
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro Bioorganic & Medicinal Chemistry, 23 (17) Sept 2015 DOI: 10.1016/j.bmc.2015.06.061
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Crystal structure of a novel two domain GH78 family α-rhamnosidase from Proteins: Structure, Function, And Bioinformatics, 83 (9) Sept 2015 DOI: 10.1002/prot.24807
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Towards detailed structural understanding of α-ʟ-fucosidase: insights through X-ray crystallography and inhibitor-binding Sept 2015
Thesis I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Differential recognition preferences of the three Src homology 3 (SH3) domains from the adaptor CD2-associated protein (CD2AP), and direct association with Ras and Rab interactor 3 (RIN3) Journal Of Biological Chemistry, Aug 2015 DOI: 10.1074/jbc.M115.637207
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The soluble Y115E–Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease Acta Crystallographica Section F Structural Biology Communications, 71 (8) Aug 2015 DOI: 10.1107/S2053230X15010389
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase Medchemcomm, 6 (10) Aug 2015 DOI: 10.1039/C5MD00241A
Conformationally restricted calpain inhibitors Chemical Science, Aug 2015 DOI: 10.1039/C5SC01158B
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug resistance Cancer Research, 75 (16) Aug 2015 DOI: 10.1158/0008-5472.CAN-14-3272
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The GH130 family of mannoside phosphorylases contains glycoside hydrolases that target beta-1,2 mannosidic linkages in Candida mannan Journal Of Biological Chemistry, Aug 2015 DOI: 10.1074/jbc.M115.681460
Mechanism of phospho-ubiquitin-induced PARKIN activation Nature, 524 (7565) Aug 2015 DOI: 10.1038/nature14879
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Structural studies reveal the functional modularity of the Scc2-Scc4 cohesin loader Cell Reports, 12 (5) Aug 2015 DOI: 10.1016/j.celrep.2015.06.071
Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction Febs Journal, 282 (16) Aug 2015 DOI: 10.1111/febs.13212
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan Elife, 4 Jul 2015 DOI: 10.7554/eLife.06554
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of the stationary phase survival protein YuiC from B.subtilis Bmc Structural Biology, 15 Jul 2015 DOI: 10.1186/s12900-015-0039-z
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structural characterization of the principal mRNA-export factor Mex67–Mtr2 from Chaetomium thermophilum Acta Crystallographica Section F Structural Biology Communications, 71 (7) Jul 2015 DOI: 10.1107/S2053230X15008766
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases Bioorganic & Medicinal Chemistry, 23 (13) Jul 2015 DOI: 10.1016/j.bmc.2015.05.005
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
The structure of Na+-translocating of NADH:ubiquinone oxidoreductase of Vibrio cholerae: implications on coupling between electron transfer and Na+ transport Biological Chemistry, 396 (9-10) Jul 2015 DOI: 10.1515/hsz-2015-0128
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody Proceedings Of The National Academy Of Sciences, 112 (30) Jul 2015 DOI: 10.1073/pnas.1510816112
Structures of CD6 and its ligand CD166 give insight into their interaction Structure, 23 (8) Jul 2015 DOI: 10.1016/j.str.2015.05.019
Identification of a class of protein ADP-ribosylating sirtuins in microbial pathogens Molecular Cell, 59 (2) Jul 2015 DOI: 10.1016/j.molcel.2015.06.013
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-mer peptide Journal Of Biological Chemistry, 290 (31) Jul 2015 DOI: 10.1074/jbc.M114.622522
Bisthiazolidines: a substrate-mimicking scaffold as an inhibitor of the NDM-1 carbapenemase Acs Infectious Diseases, 1 (11) Jul 2015 DOI: 10.1021/acsinfecdis.5b00046
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Recruitment of VPS33a to HOPS by VPS16 is required for lysosome fusion with endosomes and autophagosomes Traffic, 16 (7) Jul 2015 DOI: 10.1111/tra.12283
Neuronal calcium sensor-1 binds the D2 dopamine receptor and g-protein-coupled receptor kinase 1 (GRK1) peptides using different modes of interactions Journal Of Biological Chemistry, 290 (30) Jul 2015 DOI: 10.1074/jbc.M114.627059
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Fragment-based discovery of potent and selective DDR1/2 inhibitors Acs Medicinal Chemistry Letters, 6 (7) Jul 2015 DOI: 10.1021/acsmedchemlett.5b00143
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Crystal structure of a COG4313 outer membrane channel Scientific Reports, 5 Jul 2015 DOI: 10.1038/srep11927
Expression, purification and crystallization of a family 55 Beta-1,3-glucanase from Chaetomium thermophilum Acta Crystallographica Section F Structural Biology Communications, 71 June 2015 DOI: 10.1107/S2053230X15006366
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
The structure of the giant haemoglobin from Glossoscolex paulistus Acta Crystallographica Section D Biological Crystallography, 71 (6) June 2015 DOI: 10.1107/S1399004715005453
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Pharmacophore-based virtual screening to discover new active compounds for human choline kinase α1 Molecular Informatics, 34 June 2015 DOI: 10.1002/minf.201400140
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Crystallization and preliminary crystallographic analysis of latent, active and recombinantly expressed aurone synthase, a polyphenol oxidase, from Acta Crystallographica Section F Structural Biology Communications, 71 June 2015 DOI: 10.1107/S2053230X15007542
Exploring the role of residue 228 in substrate and inhibitor recognition by VIM metallo-β-lactamases Biochemistry, 54 (20) May 2015 DOI: 10.1021/acs.biochem.5b00106
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase Acta Crystallographica Section F Structural Biology Communications, 71 (5) May 2015 DOI: 10.1107/S2053230X15003040
Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline Chembiochem, 16 May 2015 DOI: 10.1002/cbic.201402625
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Discovery and characterisation of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries Febs Journal, 282 (15) May 2015 DOI: 10.1111/febs.13328
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein Nature Structural & Molecular Biology, 22 (6) May 2015 DOI: 10.1038/nsmb.3016
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation Nature Communications, 6 May 2015 DOI: 10.1038/ncomms7937
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Azasugar inhibitors as pharmacological chaperones for Krabbe disease Chemical Science, 6 (5) May 2015 DOI: 10.1039/C5SC00754B
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Selective inhibitors of cyclin G associated kinase (GAK) as anti-hepatitis C agents Journal Of Medicinal Chemistry, 58 (8) Apr 2015 DOI: 10.1021/jm501759m
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Molecular mechanisms of human IRE1 activation through dimerization and ligand binding Oncotarget, 6 Apr 2015 DOI: 10.18632/oncotarget.3864
Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site Febs Open Bio, 5 Apr 2015 DOI: 10.1016/j.fob.2015.03.013
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding Elife, 4 Apr 2015 DOI: 10.7554/eLife.05345
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes Chemical Science, 6 (6) Apr 2015 DOI: 10.1039/C5SC00913H
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases Structure, 23 (4) Apr 2015 DOI: 10.1016/j.str.2015.01.014
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Selective targeting of the TPX2 site of importin-α using fragment-based ligand design Chemmedchem, Apr 2015 DOI: 10.1002/cmdc.201500014
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases Elife, 4 Mar 2015 DOI: 10.7554/eLife.04871
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide Acta Crystallographica Section F Structural Biology Communications, 71 (3) Mar 2015 DOI: 10.1107/S2053230X15001065
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Vaccinia virus protein A49 is an unexpected member of the B-cell lymphoma (Bcl)-2 protein family Journal Of Biological Chemistry, 290 (10) Mar 2015 DOI: 10.1074/jbc.M114.624650
10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A Journal Of Medicinal Chemistry, 58 (7) Mar 2015 DOI: 10.1021/jm501994d
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Proceedings Of The National Academy Of Sciences, 112 (9) Mar 2015 DOI: 10.1073/pnas.1419028112
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Synthesis of dimeric ADP-ribose and its structure with human poly(ADP-ribose) glycohydrolase Journal Of The American Chemical Society, 137 (10) Mar 2015 DOI: 10.1021/ja512528p
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structure and function of a Clostridium difficile sortase enzyme Scientific Reports, 5 (9449) Mar 2015 DOI: 10.1038/srep09449
Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states Acta Crystallographica Section D Biological Crystallography, 71 Mar 2015 DOI: 10.1107/S1399004714027928
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
The structure of C290A: C393A Aurora A provides structural insights into kinase regulation Acta Crystallographica Section F Structural Biology Communications, 71 Mar 2015 DOI: 10.1107/S2053230X15002290
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structures of the Apo and FAD-bound forms of 2-hydroxybiphenyl 3-monooxygenase (HbpA) locate activity hotspots identified by using directed evolution Chembiochem, Mar 2015 DOI: 10.1002/cbic.201402701
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Evidence for a boat conformation at the transition state of GH76 α-1,6-mannanases--key enzymes in bacterial and fungal mannoprotein metabolism Angewandte Chemie International Edition, Mar 2015 DOI: 10.1002/anie.201410502
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove Acta Crystallographica Section D Biological Crystallography, 71 (3) Mar 2015 DOI: 10.1107/S139900471402776X
The role of monovalent cations in the ATPase reaction of DNA gyrase Acta Crystallographica Section D, 71 Feb 2015 DOI: 10.1107/S1399004715002916
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Family 46 Carbohydrate-Binding Modules contribute to the enzymatic hydrolysis of xyloglucan and beta-1,3-1,4-glucans through distinct mechanisms Journal Of Biological Chemistry, Feb 2015 DOI: 10.1074/jbc.M115.637827
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface Nucleic Acids Research, 43 (3) Feb 2015 DOI: 10.1093/nar/gkv030
A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape Retrovirology, 12 Feb 2015 DOI: 10.1186/s12977-015-0149-5
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Notum deacylates Wnt proteins to suppress signalling activity Nature, 519 (7542) Feb 2015 DOI: 10.1038/nature14259
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystallization and preliminary crystallographic analysis of the putative sugar-binding protein Msmeg_0515 (AgaE) from Acta Crystallographica Section F Structural Biology Communications, 71 Feb 2015 DOI: 10.1107/S2053230X15000035
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA Nucleic Acids Research, 43 (3) Feb 2015 DOI: 10.1093/nar/gkv032
Exploiting the hydrophobic terrain in fucosidases with aryl-substituted pyrrolidine iminosugars Chembiochem, 16 (2) Jan 2015 DOI: 10.1002/cbic.201402509
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7 Febs Journal, 282 (2) Jan 2015 DOI: 10.1111/febs.13140
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Targeting a dynamic protein–protein interaction: fragment screening against the malaria myosin a motor complex Chemmedchem, 10 (1) Jan 2015 DOI: 10.1002/cmdc.201402357
Subunit disassembly and inhibition of TNF by a semi-synthetic bicyclic peptide Protein Engineering Design And Selection, 28 (2) Jan 2015 DOI: 10.1093/protein/gzu055
The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages Plos One, 10 Jan 2015 DOI: 10.1371/journal.pone.0115344
Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1 Chembiochem, 16 (1) Jan 2015 DOI: 10.1002/cbic.201402512
- Umakhanth Venkatraman Girija, Christopher Furze, Alex Gingras, Takayuki Yoshizaki, Katsuki Ohtani, Jamie E Marshall, A Katrine Wallis, Wilhelm J Schwaeble, Mohammed El-Mezgueldi, Daniel A Mitchell, Peter Moody, Nobutaka Wakamiya, Russell Wallis, "Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome", Bmc Biology, 13 (2015), DOI: 10.1186/s12915-015-0136-2
- Chi T. Wong, Yingqi Xu, Akshari Gupta, James A. Garnett, Steve J. Matthews, Stephen A. Hare, "Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family", Nature Communications, 6 (2015), DOI: 10.1038/ncomms10172
- Pan F. Chan, Velupillai Srikannathasan, Jianzhong Huang, Haifeng Cui, Andrew P. Fosberry, Minghua Gu, Michael M. Hann, Martin Hibbs, Paul Homes, Karen Ingraham, Jason Pizzollo, Carol Shen, Anthony J. Shillings, Claus E. Spitzfaden, Robert Tanner, Andrew J. Theobald, Robert A. Stavenger, Benjamin D. Bax, Michael N. Gwynn, "Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin", Nature Communications, 6 (2015), DOI: 10.1038/ncomms10048
- Oakley B Cox, Tobias Krojer, Patrick Collins, Octovia Monteiro, Romain Talon, Anthony Bradley, Oleg Fedorov, Jahangir Amin, Brian D. Marsden, John Spencer, Frank Von Delft, Paul E. Brennan, "A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain", Chemical Science (2015), DOI: 10.1039/C5SC03115J
- Joseph A. Newman, Christopher D. O. Cooper, Hazel Aitkenhead, Opher Gileadi, "Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology- mediated end-joining pathway", Structure, 23 (12), 2319 - 2330 (2015), DOI: 10.1016/j.str.2015.10.014
- Mirella Vivoli, Misha Isupov, Rebecca Nicholas, Andrew Hill, Andrew e. Scott, Paul Kosma, Joann l. Prior, Nicholas Harmer, "Unraveling the B. pseudomalleiheptokinase WcbL: from structure to drug discovery", Chemistry & Biology, 22, 1622 - 1632 (2015), DOI: 10.1016/j.chembiol.2015.10.015
- A. A. Marusiak, N. L. Stephenson, H. Baik, E. W. Trotter, Y. Li, K. Blyth, S. Mason, P. Chapman, L. A. Puto, J. A. Read, C. Brassington, H. K. Pollard, C. Phillips, I. Green, R. Overman, M. Collier, E. Testoni, C. Miller, T. Hunter, O. J. Sansom, "Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis", Cancer Research (2015), DOI: 10.1158/0008-5472.CAN-15-0701-T
- Magdalena Korczynska, Daniel D. Le, Noah Younger, Elisabet Gregori-Puigjané, Anthony Tumber, Tobias Krojer, Velupillai Srikannathasan, Carina Gileadi, Radoslaw Nowak, Eriko Iwasa, Samuel B. Pollock, Idelisse Ortiz Torres, Udo Oppermann, Brian K. Shoichet, Danica Galonić Fujimori, "Docking and linking of fragments to discover Jumonji histone demethylase inhibitors", Journal Of Medicinal Chemistry (2015), DOI: 10.1021/acs.jmedchem.5b01527
- [Thesis] Michael Nicosia, "Structural studies of alpha2 macroglobulin from Limulus polyphemus" (2015)
- [Book Chapter] Raymond J. Owens, Pierre Aller, Juan Sanchez-Weatherby, James Foadi, Graeme Winter, Carina Lobley, Danny Axford, Alun Ashton, Domenico Bellini, Jose Brandao-Neto, Simone Culurgioni, Alice Douangamath, Ramona Duman, Gwyndaf Evans, Stuart Fisher, Ralf Flaig, Dave Hall, Petra Lukacik, Marco Mazzorana, Katherine Mcauley, "Application of in situ diffraction in high-throughput structure determination platforms", Methods In Molecular Biology, 1261, 233-253 (2015), DOI: 10.1007/978-1-4939-2230-7_13
- Mishail N. Isupov, Ewald Schröder, Robert P. Gibson, Jean Beecher, Giuliana Donadio, Vahid Saneei, Stephlina A. Dcunha, Emma J. Mcghie, Christopher Sayer, Colin F. Davenport, Peter C. Lau, Yoshie Hasegawa, Hiroaki Iwaki, Maria Kadow, Kathleen Balke, Uwe T. Bornscheuer, Gleb Bourenkov, Jennifer Littlechild, "The oxygenating constituent of 3,6-diketocamphane monooxygenase from the CAM plasmid of Pseudomonas putida: the first crystal structure of a type II Baeyer-Villiger monooxygenase", Acta Crystallographica Section D Biological Crystallography, 71 (11), 2344 - 2353 (2015), DOI: 10.1107/S1399004715017939
- Christopher Sayer, Zalan Szabo, Michail N. Isupov, Colin Ingham, Jennifer A Littlechild, "The structure of a novel thermophilic esterase from the planctomycetes species, Thermogutta terrifontis reveals an open active site due to a minimal ‘cap’ domain", Frontiers In Microbiology, 6 (2015), DOI: 10.3389/fmicb.2015.01294
- Goodluck Uzodinma Onwukwe, M. Kristian Koski, Petri Pihko, Werner Schmitz, Rikkert Wierenga, "Structures of yeast peroxisomal [Delta]3,[Delta]2-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole", Acta Crystallographica Section D Biological Crystallography, 71, 2178 - 2191 (2015), DOI: 10.1107/S139900471501559X
- C. K. Allerston, S. Y. Lee, J. A. Newman, C. J. Schofield, P. J. Mchugh, O. Gileadi, "The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities", Nucleic Acids Research (2015), DOI: 10.1093/nar/gkv1256
- T. Arakawa, T. Kobayashi-Yurugi, Y. Alguel, H. Iwanari, H. Hatae, M. Iwata, Y. Abe, T. Hino, C. Ikeda-Suno, H. Kuma, D. Kang, T. Murata, T. Hamakubo, A. D. Cameron, T. Kobayashi, N. Hamasaki, S. Iwata, "Crystal structure of the anion exchanger domain of human erythrocyte band 3", Science, 350 (6261), 680 - 684 (2015), DOI: 10.1126/science.aaa4335
- Rhiannon M Evans, Emily J Brooke, Sara A M Wehlin, Elena Nomerotskaia, Frank Sargent, Stephen B Carr, Simon E V Phillips, Fraser A Armstrong, "Mechanism of hydrogen activation by [NiFe] hydrogenases", Nature Chemical Biology (2015), DOI: 10.1038/nchembio.1976
- Hajo Kries, Lorenzo Caputi, Clare E M Stevenson, Mohammed O Kamileen, Nathaniel H Sherden, Fernando Geu-Flores, David Lawson, Sarah E O'Connor, "Structural determinants of reductive terpene cyclization in iridoid biosynthesis", Nature Chemical Biology (2015), DOI: 10.1038/nchembio.1955
- Jingxu Guo, Peter Erskine, Alun Coker, Steve P. Wood, Jonathan Cooper, "Structure of a Kunitz-type potato cathepsin D inhibitor", Journal Of Structural Biology, 192 (3), 554–560 (2015), DOI: 10.1016/j.jsb.2015.10.020
- Richard J. Suckling, Pak Phi Poon, Sophie M. Travis, Irina V. Majoul, Frederick M. Hughson, Philip R. Evans, Rainer Duden, David J. Owen, "Structural basis for the binding of tryptophan-based motifs by δ-COP", Proceedings Of The National Academy Of Sciences (2015), DOI: 10.1073/pnas.1506186112
- Vitor Mendes, Michal Blaszczyk, Ana Maranha, Nuno Empadinhas, Tom L. Blundell, "Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism", Scientific Reports, 5 (2015), DOI: 10.1038/srep17144
- [Thesis] Sam Horrell, "Development of crystallographic techniques and their application to several protein targets" (2015)
- Marcio V. Ramos, Raquel S. B. De Oliveira, Humberto M. Pereira, Frederico B. M. B. Moreno, Marina D. P. Lobo, Luciana M. Rebelo, Jose Brandao-Neto, Jeanlex S. De Sousa, Ana C. O. Monteiro-Moreira, Cléverson D. T. Freitas, Thalles Barbosa Grangeiro, "Crystal structure of an antifungal osmotin-like protein from Calotropis procera and its effects on Fusarium solani spores, as revealed by atomic force microscopy: Insights into the mechanism of action", Phytochemistry (2015), DOI: 10.1016/j.phytochem.2015.09.012
- Edgar Morales-Rios, Martin Montgomery, Andrew Leslie, John E. Walker, "Structure of ATP synthase from Paracoccus denitrificans determined by X-ray crystallography at 4.0 Å resolution", Proceedings Of The National Academy Of Sciences (2015), DOI: 10.1073/pnas.1517542112
- Patricia Paracuellos Torrecilla, David Briggs, Federico Carafoli, Tan Loncar, Erhard Hohenester, "Insights into collagen uptake by C-type mannose receptors from the crystal structure of Endo180 domains 1–4", Structure (2015), DOI: 10.1016/j.str.2015.09.004
- Eugene Valkov, Murray Stewart, "1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex", Acta Crystallographica Section F Structural Biology Communications, 71, 1318 - 1321 (2015), DOI: 10.1107/S2053230X1501643X
- Justin M. Bradley, Dimitri A. Svistunenko, Tamara L. Lawson, Andrew M Hemmings, Geoffrey R. Moore, Nick Le Brun, "Three aromatic residues are required for electron transfer during iron mineralization in bacterioferritin", Angewandte Chemie International Edition (2015), DOI: 10.1002/anie.201507486
- Petra Lukacik, Carina Lobley, Mario Bumann, Victoria Arena De Souza, Raymond J. Owens, Paul W. O'Toole, Martin A. Walsh, "High-resolution structures of Lactobacillus salivarius transketolase in the presence and absence of thiamine pyrophosphate", Acta Crystallographica Section F Structural Biology Communications, 71, 1327 - 1334 (2015), DOI: 10.1107/S2053230X1501657X
- Richard Tunnicliffe, Mitchell Schacht, Colin Levy, Thomas A. Jowitt, Rozanne M. Sandri-Goldin, Alexander P. Golovanov, "The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer", Scientific Reports, 5 (2015), DOI: 10.1038/srep11234
- Ellis C. O'Neill, Clare E. M. Stevenson, Krit Tantanarat, Dimitrios Latousakis, Matthew I. Donaldson, Martin Rejzek, Sergey A. Nepogodiev, Tipaporn Limpaseni, Robert A. Field, David M. Lawson, "Structural dissection of the maltodextrin disproportionation cycle of the arabidopsis plastidial enzyme DPE1", Journal Of Biological Chemistry (2015), DOI: 10.1074/jbc.M115.682245
- Jamie E. Marshall, Bayan H. A. Faraj, Alexandre R. Gingras, Rana Lonnen, Md. Arif Sheikh, Mohammed El-Mezgueldi, Peter C. E. Moody, Peter W. Andrew, Russell Wallis, "The crystal structure of pneumolysin at 2.0 Å resolution reveals the molecular packing of the pre-pore complex", Scientific Reports, 5 (2015), DOI: 10.1038/srep13293
- J. Guo, P. Erskine, A. R. Coker, J. Gor, S. J. Perkins, S. P. Wood, J. B. Cooper, "Extension of resolution and oligomerization-state studies of 2,4′-dihydroxyacetophenone dioxygenase from", Acta Crystallographica Section F Structural Biology Communications, 71, 1258 - 1263 (2015), DOI: 10.1107/S2053230X15015873
- Fatma Işık Üstok, Dimitri Y Chirgadze, Graham Christie, "Structural and functional analysis of SleL, a peptidoglycan lysin involved in germination of Bacillus spores", Proteins: Structure, Function, And Bioinformatics, 83 (10), 1787 - 1799 (2015), DOI: 10.1002/prot.24861
- Jonathan M Elkins, Vita Fedele, Marta Szklarz, Kamal R Abdul Azeez, Eidarus Salah, Jowita Mikolajczyk, Sergei Romanov, Nikolai Sepetov, Xi-Ping Huang, Bryan L Roth, Ayman Al Haj Zen, Denis Fourches, Eugene Muratov, Alex Tropsha, Joel Morris, Beverly A Teicher, Mark Kunkel, David H Drewry, William J Zuercher, Stefan Knapp, "Comprehensive characterization of the Published Kinase Inhibitor Set", Nature Biotechnology (2015), DOI: 10.1038/nbt.3374
- A. Kumar, J. D. Aguirre, T. E. Condos, R. J. Martinez-Torres, V. K. Chaugule, R. Toth, R. Sundaramoorthy, P. Mercier, A. Knebel, D. E. Spratt, K. R. Barber, G. S. Shaw, H. Walden, "Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis", The Embo Journal, 34, 2506 - 2521 (2015), DOI: 10.15252/embj.201592337
- Shalini Pathak, Jana Alonso, Marianne Schimpl, Karim Rafie, David E. Blair, Vladimir S. Borodkin, Alexander W. Schüttelkopf, Osama Albarbarawi, Daan M. F. Van Aalten, "The active site of O-GlcNAc transferase imposes constraints on substrate sequence", Nature Structural & Molecular Biology, 22 (9), 744 - 750 (2015), DOI: 10.1038/nsmb.3063
- Jurgen Brem, Sander S. Van Berkel, David Zollman, Sook Y. Lee, Opher Gileadi, Peter J. Mchugh, Timothy R. Walsh, Michael Mcdonough, Christopher J. Schofield, "Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers", Antimicrobial Agents And Chemotherapy (2015), DOI: 10.1128/AAC.01335-15
- James E. Longbotham, Colin Levy, Linus O. Johannissen, Hanna Tarhonskaya, Shuo Jiang, Christoph Loenarz, Emily Flashman, Sam Hay, Christopher J. Schofield, Nigel S. Scrutton, "Structure and mechanism of a viral collagen prolyl hydroxylase", Biochemistry, 54 (39), 6093 - 6105 (2015), DOI: 10.1021/acs.biochem.5b00789
- K. Rostislavleva, N. Soler, Y. Ohashi, L. Zhang, E. Pardon, J. Burke, G. Masson, C. Johnson, J. Steyaert, N. T. Ktistakis, R. L. Williams, "Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes", Science, 350, aac7365 - aac7365 (2015), DOI: 10.1126/science.aac7365
- Cecilia Pozzi, Flavio Di Pisa, Caterina Bernacchioni, Silvia Ciambellotti, Paola Turano, Stefano Mangani, "Iron binding to human heavy-chain ferritin", Acta Crystallographica Section D Biological Crystallography, 71, 1909 - 1920 (2015), DOI: 10.1107/S1399004715013073
- Anthony Bradley, I. D. Wall, Frank Von Delft, D. V. S. Green, C. M. Deane, B. D. Marsden, "WONKA: objective novel complex analysis for ensembles of protein–ligand structures", Journal Of Computer-Aided Molecular Design (2015), DOI: 10.1007/s10822-015-9866-z
- Richard J. R. Elliott, Ashley Jarvis, Mohan B. Rajasekaran, Malini Menon, Leandra Bowers, Ray Boffey, Melanie Bayford, Stuart Firth-Clark, Rebekah Key, Rehan Aqil, Stewart B. Kirton, Dan Niculescu-Duvaz, Laura Fish, Filipa Lopes, Robert Mcleary, Ines Trindade, Elisenda Vendrell, Felix Munkonge, Alan Ashworth, Christopher Lord, "Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors", Medchemcomm, 6 (9), 1687 - 1692 (2015), DOI: 10.1039/C5MD00210A
- Christopher Owen, Petra Lukacik, Jane A. Potter, Olivia Sleator, Garry Taylor, Martin A. Walsh, "Streptococcus Pneumoniae NanC: structural insights into the specificity and mechanism of a sialidase that produces a sialidase inhibitor", Journal Of Biological Chemistry (2015), DOI: 10.1074/jbc.M115.673632
- Elena G. Kovaleva, Melanie S. Rogers, John D. Lipscomb, "Structural basis for substrate and oxygen activation in homoprotocatechuate 2,3-dioxygenase: roles of conserved active site histidine 200", Biochemistry, 54 (34), 5329 - 5339 (2015), DOI: 10.1021/acs.biochem.5b00709
- Justyna Wojdyla, Erin Cutts, Renata Kaminska, Grigorios Papadakos, Jonathan T. S. Hopper, Phillip J. Stansfeld, David Staunton, Carol V. Robinson, Colin Kleanthous, "Structure and function of the Escherichia coli Tol-Pal stator protein TolR", Journal Of Biological Chemistry (2015), DOI: 10.1074/jbc.M115.671586
- Sean Froese, Amit Michaeli, Thomas Mccorvie, Tobias Krojer, Meitav Sasi, Esther Melaev, Amiram Goldblum, Maria Zatsepin, Alexander Lossos, Rafael Álvarez, Pablo V. Escribá, Berge A. Minassian, Frank Von Delft, Or Kakhlon, Wyatt Yue, "Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design", Human Molecular Genetics, 24 (20), 5667 - 5676 (2015), DOI: 10.1093/hmg/ddv280
- Elizabeth Anscombe, Elisa Meschini, Regina Mora-Vidal, Mathew p. Martin, David Staunton, Matthis Geitmann, U. helena Danielson, Will a. Stanley, Lan z. Wang, Tristan Reuillon, Bernard t. Golding, Celine Cano, David r. Newell, Martin Noble, Stephen r. Wedge, Jane a. Endicott, Roger j. Griffin, "Identification and characterization of an irreversible inhibitor of CDK2", Chemistry & Biology, 22 (9), 1159 - 1164 (2015), DOI: 10.1016/j.chembiol.2015.07.018
- Xue-Yuan Pei, Patricia Bralley, George H Jones, Ben Luisi, "Linkage of catalysis and 5′ end recognition in ribonuclease RNase J", Nucleic Acids Research, 43 (16), 8066 - 8076 (2015), DOI: 10.1093/nar/gkv732
- Mun Chiang Chan, Onur Atasoylu, Emma Hodson, Anthony Tumber, Ivanhoe K. H. Leung, Rasheduzzaman Chowdhury, Verónica Gómez-Pérez, Marina Demetriades, Anna M. Rydzik, James Holt-Martyn, Ya-Min Tian, Tammie Bishop, Timothy D. W. Claridge, Akane Kawamura, Christopher W. Pugh, Peter J. Ratcliffe, Christopher J. Schofield, Sonia Rocha, "Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain", Plos One, 10 (7) (2015), DOI: 10.1371/journal.pone.0132004
- Helen A. Paine, Amit Nathubhai, Esther C.y. Woon, Peter T. Sunderland, Pauline J. Wood, Mary F. Mahon, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Mohit Narwal, Lari Lehtiö, Michael D. Threadgill, "Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro", Bioorganic & Medicinal Chemistry, 23 (17), 5891 - 5908 (2015), DOI: 10.1016/j.bmc.2015.06.061
- Ellis C. O'Neill, Clare Stevenson, Michael J. Paterson, Martin Rejzek, Anne-Laure Chauvin, David Lawson, Robert A. Field, "Crystal structure of a novel two domain GH78 family α-rhamnosidase from", Proteins: Structure, Function, And Bioinformatics, 83 (9), 1742 - 1749 (2015), DOI: 10.1002/prot.24807
- [Thesis] Daniel Wayne Wright, "Towards detailed structural understanding of α-ʟ-fucosidase: insights through X-ray crystallography and inhibitor-binding" (2015)
- Evgenia Rouka, Philip C. Simister, Melanie Janning, Joerg Kumbrink, Tassos Konstantinou, João R. C. Muniz, Dhira Joshi, Nicola O'Reilly, Rudolf Volkmer, Brigitte Ritter, Stefan Knapp, Frank Von Delft, Kathrin H. Kirsch, Stephan M. Feller, "Differential recognition preferences of the three Src homology 3 (SH3) domains from the adaptor CD2-associated protein (CD2AP), and direct association with Ras and Rab interactor 3 (RIN3)", Journal Of Biological Chemistry (2015), DOI: 10.1074/jbc.M115.637207
- Flavio Dipisa, Cecilia Pozzi, Manuela Benvenuti, Matteo Andreini, Guido Marconi, Stefano Mangani, "The soluble Y115E–Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease", Acta Crystallographica Section F Structural Biology Communications, 71 (8), 986 - 992 (2015), DOI: 10.1107/S2053230X15010389
- Mark D. Rackham, Zhiyong Yu, James A. Brannigan, William P. Heal, Daniel Paape, K. Victoria Barker, Anthony J. Wilkinson, Deborah F. Smith, Robin J. Leatherbarrow, Edward W. Tate, "Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase", Medchemcomm, 6 (10), 1761 - 1766 (2015), DOI: 10.1039/C5MD00241A
- S. E. Adams, E. J. Robinson, D. J. Miller, P. Rizkallah, M. B. Hallett, R. K. Allemann, "Conformationally restricted calpain inhibitors", Chemical Science (2015), DOI: 10.1039/C5SC01158B
- M. D. Gurden, Isaac Westwood, A. Faisal, S. Naud, K. M. J. Cheung, C. Mcandrew, A. Wood, J. Schmitt, K. Boxall, G. Mak, P. Workman, R. Burke, S. Hoelder, J. Blagg, Rob Van Montfort, S. Linardopoulos, "Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug resistance", Cancer Research, 75 (16), 3340 - 3354 (2015), DOI: 10.1158/0008-5472.CAN-14-3272
- Fiona Cuskin, Arnaud Baslé, Simon Ladevèze, Alison M. Day, Harry J. Gilbert, Gideon J. Davies, Gabrielle Potocki-Véronèse, Elisabeth C. Lowe, "The GH130 family of mannoside phosphorylases contains glycoside hydrolases that target beta-1,2 mannosidic linkages in Candida mannan", Journal Of Biological Chemistry (2015), DOI: 10.1074/jbc.M115.681460
- Tobias Wauer, Michal Simicek, Alexander Schubert, David Komander, "Mechanism of phospho-ubiquitin-induced PARKIN activation", Nature, 524 (7565), 370 - 374 (2015), DOI: 10.1038/nature14879
- William C. H. Chao, Yasuto Murayama, Sofía Muñoz, Alessandro Costa, Frank Uhlmann, Martin R. Singleton, "Structural studies reveal the functional modularity of the Scc2-Scc4 cohesin loader", Cell Reports, 12 (5), 719 - 725 (2015), DOI: 10.1016/j.celrep.2015.06.071
- Domen Zafred, Barbara Steiner, Andrea R. Teufelberger, Altijana Hromic, P. Andrew Karplus, Christopher J. Schofield, Silvia Wallner, Peter Macheroux, "Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction", Febs Journal, 282 (16), 3060 - 3074 (2015), DOI: 10.1111/febs.13212
- Tao-Hsin Chang, Fu-Lien Hsieh, Matthias Zebisch, Karl Harlos, Jonathan Elegheert, E. Yvonne Jones, "Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan", Elife, 4 (2015), DOI: 10.7554/eLife.06554
- Doris Quay, Ambrose Cole, Adam Cryar, Konstantinos Thalassinos, Mark Williams, Sanjib Bhakta, Nicholas Keep, "Structure of the stationary phase survival protein YuiC from B.subtilis", Bmc Structural Biology, 15, 1349-1357 (2015), DOI: 10.1186/s12900-015-0039-z
- Shintaro Aibara, Eugene Valkov, Meindert Lamers, Lyudmila Dimitrova, Ed Hurt, Murray Stewart, "Structural characterization of the principal mRNA-export factor Mex67–Mtr2 from Chaetomium thermophilum", Acta Crystallographica Section F Structural Biology Communications, 71 (7), 876 - 888 (2015), DOI: 10.1107/S2053230X15008766
- Katerina Kumpan, Amit Nathubhai, Chenlu Zhang, Pauline J. Wood, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Lari Lehtio, Michael D. Threadgill, "Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases", Bioorganic & Medicinal Chemistry, 23 (13), 3013 - 3032 (2015), DOI: 10.1016/j.bmc.2015.05.005
- Julia Steuber, Georg Vohl, Valentin Muras, Charlotte Toulouse, Björn Claußen, Thomas Vorburger, Guenter Fritz, "The structure of Na+-translocating of NADH:ubiquinone oxidoreductase of Vibrio cholerae: implications on coupling between electron transfer and Na+ transport", Biological Chemistry, 396 (9-10) (2015), DOI: 10.1515/hsz-2015-0128
- Xiaoli Xiong, Davide Corti, Junfeng Liu, Debora Pinna, Mathilde Foglierini, Lesley J. Calder, Stephen R. Martin, Yi Pu Lin, Phil Walker, Patrick J. Collins, Isabella Monne, Amorsolo L. Suguitan, Celia Santos, Nigel J. Temperton, Kanta Subbarao, Antonio Lanzavecchia, Steven Gamblin, John J. Skehel, "Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody", Proceedings Of The National Academy Of Sciences, 112 (30), 9430 - 9435 (2015), DOI: 10.1073/pnas.1510816112
- Paul Chappell, Lee i. Garner, Jun Yan, Clive Metcalfe, Deborah Hatherley, Steven Johnson, Carol v. Robinson, Susan Lea, Marion h. Brown, "Structures of CD6 and its ligand CD166 give insight into their interaction", Structure, 23 (8), 1426 - 1436 (2015), DOI: 10.1016/j.str.2015.05.019
- Johannes Gregor Matthias Rack, Rosa Morra, Eva Barkauskaite, Rolf Kraehenbuehl, Antonio Ariza, Yue Qu, Mary Ortmayer, Orsolya Leidecker, David r Cameron, Ivan Matic, Anton y. Peleg, David Leys, Ana Traven, Ivan Ahel, "Identification of a class of protein ADP-ribosylating sirtuins in microbial pathogens", Molecular Cell, 59 (2), 309–320 (2015), DOI: 10.1016/j.molcel.2015.06.013
- Chihiro Motozono, James A. Pearson, Evy De Leenheer, Pierre J. Rizkallah, Konrad Beck, Andrew Trimby, Andrew K. Sewell, F. Susan Wong, David K. Cole, "Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-mer peptide", Journal Of Biological Chemistry, 290 (31), 18924 - 18933 (2015), DOI: 10.1074/jbc.M114.622522
- Mariano M. González, Magda Kosmopoulou, Maria F. Mojica, Valerie Castillo, Philip Hinchliffe, Ilaria Pettinati, Jurgen Brem, Christopher J. Schofield, Graciela Mahler, Robert A. Bonomo, Leticia I. Llarrull, James Spencer, Alejandro J. Vila, "Bisthiazolidines: a substrate-mimicking scaffold as an inhibitor of the NDM-1 carbapenemase", Acs Infectious Diseases, 1 (11) (2015), DOI: 10.1021/acsinfecdis.5b00046
- Lena Wartosch, Ufuk Günesdogan, Stephen C. Graham, J. Paul Luzio, "Recruitment of VPS33a to HOPS by VPS16 is required for lysosome fusion with endosomes and autophagosomes", Traffic, 16 (7), 727 - 742 (2015), DOI: 10.1111/tra.12283
- Sravan Pandalaneni, Vijaykumar Karuppiah, Muhammad Saleem, Lee P. Haynes, Robert D. Burgoyne, Olga Mayans, Jeremy Derrick, Lu-Yun Lian, "Neuronal calcium sensor-1 binds the D2 dopamine receptor and g-protein-coupled receptor kinase 1 (GRK1) peptides using different modes of interactions", Journal Of Biological Chemistry, 290 (30), 18744 - 18756 (2015), DOI: 10.1074/jbc.M114.627059
- Christopher W. Murray, Valerio Berdini, Ildiko M. Buck, Maria E. Carr, Anne Cleasby, Joseph E. Coyle, Jayne E. Curry, James E. H. Day, Phillip J. Day, Keisha Hearn, Aman Iqbal, Lydia Y. W. Lee, Vanessa Martins, Paul N. Mortenson, Joanne M. Munck, Lee W. Page, Sahil Patel, Susan Roomans, Kirsten Smith, Emiliano Tamanini, "Fragment-based discovery of potent and selective DDR1/2 inhibitors", Acs Medicinal Chemistry Letters, 6 (7), 798 - 803 (2015), DOI: 10.1021/acsmedchemlett.5b00143
- Bert Van Den Berg, Satya Prathyusha Bhamidimarri, Mathias Winterhalter, "Crystal structure of a COG4313 outer membrane channel", Scientific Reports, 5 (2015), DOI: 10.1038/srep11927
- Tassos Papageorgiou, Duo Chuan Li, "Expression, purification and crystallization of a family 55 Beta-1,3-glucanase from Chaetomium thermophilum", Acta Crystallographica Section F Structural Biology Communications, 71, 680 - 683 (2015), DOI: 10.1107/S2053230X15006366
- José Fernando Ruggiero Bachega, Fernando Vasconcelos Maluf, Babak Andi, Humberto D'Muniz Pereira, Marcelo Falsarella Carazzollea, Allen M. Orville, Marcel Tabak, Jose Brandao-Neto, Richard Charles Garratt, Eduardo Horjales Reboredo, "The structure of the giant haemoglobin from Glossoscolex paulistus", Acta Crystallographica Section D Biological Crystallography, 71 (6), 1257 - 1271 (2015), DOI: 10.1107/S1399004715005453
- Vladimir Poroikov, Lucía Serrán-Aguilera, Roberto Nuti, Luisa C. López-Cara, Miguel Á. Gallo Mezo, Antonio Macchiarulo, Antonio Entrena, Ramon Hurtado-Guerrero, "Pharmacophore-based virtual screening to discover new active compounds for human choline kinase α1", Molecular Informatics, 34, 458 - 466 (2015), DOI: 10.1002/minf.201400140
- Christian Molitor, Stephan Mauracher, Annette Rompel, "Crystallization and preliminary crystallographic analysis of latent, active and recombinantly expressed aurone synthase, a polyphenol oxidase, from", Acta Crystallographica Section F Structural Biology Communications, 71, 746 - 751 (2015), DOI: 10.1107/S2053230X15007542
- Maria F. Mojica, S. Graciela Mahler, Christopher R. Bethel, Magdalena A. Taracila, Magda Kosmopoulou, Krisztina M. Papp-Wallace, Leticia I. Llarrull, Brigid M. Wilson, Steven H. Marshall, Christopher J. Wallace, Maria V. Villegas, Michael E. Harris, Alejandro J. Vila, James Spencer, Robert A. Bonomo, "Exploring the role of residue 228 in substrate and inhibitor recognition by VIM metallo-β-lactamases", Biochemistry, 54 (20), 3183 - 3196 (2015), DOI: 10.1021/acs.biochem.5b00106
- David A Robinson, Paul G. Wyatt, "Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase", Acta Crystallographica Section F Structural Biology Communications, 71 (5), 586 - 593 (2015), DOI: 10.1107/S2053230X15003040
- Henry Man, Elizabeth Wells, Shahed Hussain, Friedemann Leipold, Sam Hart, Johan Turkenburg, Nicholas J. Turner, Gideon Grogan, "Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline", Chembiochem, 16, 1052 - 1059 (2015), DOI: 10.1002/cbic.201402625
- Erica Elisa Ferrandi, Christopher Sayer, Michail Isupov, Celeste Annovazzi, Carlotta Marchesi, Gianluca Iacobone, Xu Peng, Elizaveta Bonch- Osmolovskaya, Roland Wohlgemuth, Jennifer Littlechild, Daniela Monti, "Discovery and characterisation of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries", Febs Journal, 282 (15), 2879-2894 (2015), DOI: 10.1111/febs.13328
- Eleanor Healey, Benjamin Bishop, Jonathan Elegheert, Christian Bell, Sergi Padilla-Parra, Christian Siebold, "Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein", Nature Structural & Molecular Biology, 22 (6), 458 - 465 (2015), DOI: 10.1038/nsmb.3016
- Erandi Lira-Navarrete, Matilde De Las Rivas, Ismael Compañón, María Carmen Pallarés, Yun Kong, Javier Iglesias-Fernández, Gonçalo J. L. Bernardes, Jesús M. Peregrina, Carme Rovira, Pau Bernadó, Pierpaolo Bruscolini, Henrik Clausen, Anabel Lostao, Francisco Corzana, Ramon Hurtado-Guerrero, "Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation", Nature Communications, 6 (2015), DOI: 10.1038/ncomms7937
- Chris H. Hill, Agnete Viuff, Samantha Spratley, Stéphane Salamone, Stig H. Christensen, Randy Read, Nigel W. Moriarty, Henrik H. Jensen, Janet E. Deane, "Azasugar inhibitors as pharmacological chaperones for Krabbe disease", Chemical Science, 6 (5), 3075 - 3086 (2015), DOI: 10.1039/C5SC00754B
- Sona Kovackova, Lei Chang, Elena Bekerman, Gregory Neveu, Rina Barouch-Bentov, Apirat Chaikuad, Christina Heroven, Michal Šála, Steven De Jonghe, Stefan Knapp, Shirit Einav, Piet Herdewijn, "Selective inhibitors of cyclin G associated kinase (GAK) as anti-hepatitis C agents", Journal Of Medicinal Chemistry, 58 (8), 3393 - 3410 (2015), DOI: 10.1021/jm501759m
- Amar Joshi, Yvette Newbatt, P. Craig Mcandrew, Mark Stubbs, Rosemary Burke, Mark Richards, Chitra Bhatia, John J. Caldwell, Tatiana Mchardy, Ian Collins, Richard Bayliss, "Molecular mechanisms of human IRE1 activation through dimerization and ligand binding", Oncotarget, 6, 13019 - 13035 (2015), DOI: 10.18632/oncotarget.3864
- Shalini Iyer, Penelope J. La-Borde, Karl A. P. Payne, Mark R. Parsons, Anthony J. Turner, R. Elwyn Isaac, K. Ravi Acharya, "Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site", Febs Open Bio, 5, 292 - 302 (2015), DOI: 10.1016/j.fob.2015.03.013
- Paul Chappell, El Kahina Meziane, Michael Harrison, Łukasz Magiera, Clemens Hermann, Laura Mears, Antoni G Wrobel, Charlotte Durant, Lise Lotte Nielsen, Søren Buus, Nicola Ternette, William Mwangi, Colin Butter, Venugopal Nair, Trudy Ahyee, Richard Duggleby, Alejandro Madrigal, Pietro Roversi, Susan Lea, Jim Kaufman, "Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding", Elife, 4 (2015), DOI: 10.7554/eLife.05345
- Sarah A. Shepherd, Chinnan Karthikeyan, Jonathan Latham, Anna-Winona Struck, Mark L. Thompson, Binuraj Menon, Matthew Q. Styles, Colin Levy, David Leys, Jason Micklefield, "Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes", Chemical Science, 6 (6), 3454 - 3460 (2015), DOI: 10.1039/C5SC00913H
- Shoichiro Horita, John S Scotti, Cyrille Thinnes, Yousef S. Mottaghi-Taromsari, Armin Thalhammer, Wei Ge, Weishen Aik, Christoph Loenarz, Christopher J. Schofield, Michael A. Mcdonough, "Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases", Structure, 23 (4), 639 - 652 (2015), DOI: 10.1016/j.str.2015.01.014
- Rhian S. Holvey, Eugene Valkov, David Neal, Murray Stewart, Chris Abell, "Selective targeting of the TPX2 site of importin-α using fragment-based ligand design", Chemmedchem (2015), DOI: 10.1002/cmdc.201500014
- Ruming Chen, Cláudia Rato, Yahui Yan, Ana Crespillo-Casado, Hanna J Clarke, Heather P Harding, Stefan J Marciniak, Randy Read, David Ron, "G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases", Elife, 4 (2015), DOI: 10.7554/eLife.04871
- William J. Bradshaw, April K. Roberts, Clifford C. Shone, K. Ravi Acharya, "Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide", Acta Crystallographica Section F Structural Biology Communications, 71 (3), 295 - 303 (2015), DOI: 10.1107/S2053230X15001065
- Sarah Neidel, Carlos Maluquer De Motes, Daniel S. Mansur, Pavla Strnadova, Geoffrey L. Smith, Stephen C. Graham, "Vaccinia virus protein A49 is an unexpected member of the B-cell lymphoma (Bcl)-2 protein family", Journal Of Biological Chemistry, 290 (10), 5991 - 6002 (2015), DOI: 10.1074/jbc.M114.624650
- Hannes Falke, Apirat Chaikuad, Anja Becker, Nadã¨ge Loaec, Olivier Lozach, Samira Abu Jhaisha, Walter Becker, Peter G. Jones, Lutz Preu, Knut Baumann, Stefan Knapp, Laurent Meijer, Conrad Kunick, "10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A", Journal Of Medicinal Chemistry, 58 (7) (2015), DOI: 10.1021/jm501994d
- Kirsty J. Mclean, Marcus Hans, Ben Meijrink, Wibo B. Van Scheppingen, Aad Vollebregt, Kang Lan Tee, Jan-Metske Van Der Laan, David Leys, Andrew W. Munro, Marco A. Van Den Berg, "Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of", Proceedings Of The National Academy Of Sciences, 112 (9), 2847 - 2852 (2015), DOI: 10.1073/pnas.1419028112
- Michael J. Lambrecht, Matthew Brichacek, Eva Barkauskaite, Antonio Ariza, Ivan Ahel, Paul J. Hergenrother, "Synthesis of dimeric ADP-ribose and its structure with human poly(ADP-ribose) glycohydrolase", Journal Of The American Chemical Society, 137 (10), 3558 - 3564 (2015), DOI: 10.1021/ja512528p
- Christopher J. Chambers, April K. Roberts, Clifford C. Shone, K. Ravi Acharya, "Structure and function of a Clostridium difficile sortase enzyme", Scientific Reports, 5 (9449) (2015), DOI: 10.1038/srep09449
- Tereza Skálová, Jan Bláha, Karl Harlos, Jarmila Duskova, Tomáš Koval', Jan Stransky, Jindřich Hašek, Ondřej Vaněk, Jan Dohnalek, "Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states", Acta Crystallographica Section D Biological Crystallography, 71, 578 - 591 (2015), DOI: 10.1107/S1399004714027928
- Selena Burgess, Richard Bayliss, "The structure of C290A: C393A Aurora A provides structural insights into kinase regulation", Acta Crystallographica Section F Structural Biology Communications, 71, 315 - 319 (2015), DOI: 10.1107/S2053230X15002290
- Chantel N. Jensen, Tamara Mielke, Joseph E. Farrugia, Annika Frank, Henry Man, Sam Hart, Johan Turkenburg, Gideon Grogan, "Structures of the Apo and FAD-bound forms of 2-hydroxybiphenyl 3-monooxygenase (HbpA) locate activity hotspots identified by using directed evolution", Chembiochem (2015), DOI: 10.1002/cbic.201402701
- Andrew J. Thompson, Gaetano Speciale, Javier Iglesias-Fernández, Zalihe Hakki, Tyson Belz, Alan Cartmell, Richard J. Spears, Emily Chandler, Max J. Temple, Judith Stepper, Harry J. Gilbert, Carme Rovira, Spencer J. Williams, Gideon J. Davies, "Evidence for a boat conformation at the transition state of GH76 α-1,6-mannanases--key enzymes in bacterial and fungal mannoprotein metabolism", Angewandte Chemie International Edition (2015), DOI: 10.1002/anie.201410502
- Marina E Ivanova, Georgina C. Fletcher, Nicola O'Reilly, Andrew G Purkiss, Barry J. Thompson, Neil Q. Mcdonald, "Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove", Acta Crystallographica Section D Biological Crystallography, 71 (3), 555 - 564 (2015), DOI: 10.1107/S139900471402776X
- Stephen Hearnshaw, Terence Chung, Clare Stevenson, Anthony Maxwell, David Lawson, "The role of monovalent cations in the ATPase reaction of DNA gyrase", Acta Crystallographica Section D, 71, 996-1005 (2015), DOI: 10.1107/S1399004715002916
- Immacolata Venditto, Shabir Najmudin, Ana S. Luis, Luis M. A. Ferreira, Kazuo Sakka, J. Paul Knox, Harry J. Gilbert, Carlos M. G. A. Fontes, "Family 46 Carbohydrate-Binding Modules contribute to the enzymatic hydrolysis of xyloglucan and beta-1,3-1,4-glucans through distinct mechanisms", Journal Of Biological Chemistry (2015), DOI: 10.1074/jbc.M115.637827
- Shintaro Aibara, Eugene Valkov, Meindert Lamers, Murray Stewart, "Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface", Nucleic Acids Research, 43 (3), 1927 - 1936 (2015), DOI: 10.1093/nar/gkv030
- Henrik N Kløverpris, David K. Cole, Anna Fuller, Jonathan Carlson, Konrad Beck, Andrea J. Schauenburg, Pierre Rizkallah, Søren Buus, Andrew K. Sewell, Philip Goulder, "A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape", Retrovirology, 12 (2015), DOI: 10.1186/s12977-015-0149-5
- Satoshi Kakugawa, Paul F. Langton, Matthias Zebisch, Steven A. Howell, Tao-Hsin Chang, Yan Liu, Ten Feizi, Ganka Bineva, Nicola O'Reilly, Ambrosius P. Snijders, E. Yvonne Jones, Jean-Paul Vincent, "Notum deacylates Wnt proteins to suppress signalling activity", Nature, 519 (7542), 187 - 192 (2015), DOI: 10.1038/nature14259
- Feras Almourfi, H. Fiona Rodgers, Svetlana E. Sedelnikova, Patrick Baker, "Crystallization and preliminary crystallographic analysis of the putative sugar-binding protein Msmeg_0515 (AgaE) from", Acta Crystallographica Section F Structural Biology Communications, 71, 189 - 193 (2015), DOI: 10.1107/S2053230X15000035
- Shintaro Aibara, Jun Katahira, Eugene Valkov, Murray Stewart, "The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA", Nucleic Acids Research, 43 (3), 1883 - 1893 (2015), DOI: 10.1093/nar/gkv032
- Audrey Hottin, Daniel Wright, Gideon J. Davies, Jean-Bernard Behr, "Exploiting the hydrophobic terrain in fucosidases with aryl-substituted pyrrolidine iminosugars", Chembiochem, 16 (2), 277 - 283 (2015), DOI: 10.1002/cbic.201402509
- Sneha Ramaswamy, Mazen H. Sleiman, Geoffrey Masuyer, Cécile Arbez-Gindre, Maria Micha-Screttas, Theodora Calogeropoulou, Barry R. Steele, Ravi Acharya, "Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7", Febs Journal, 282 (2), 372 - 387 (2015), DOI: 10.1111/febs.13140
- Christopher Douse, Nina Vrielink, Zhang Wenlin, Ernesto Cota, Edward W. Tate, "Targeting a dynamic protein–protein interaction: fragment screening against the malaria myosin a motor complex", Chemmedchem, 10 (1), 134 - 143 (2015), DOI: 10.1002/cmdc.201402357
- S. Luzi, Y. Kondo, E. Bernard, L. K. J. Stadler, M. Vaysburd, G. Winter, P. Holliger, "Subunit disassembly and inhibition of TNF by a semi-synthetic bicyclic peptide", Protein Engineering Design And Selection, 28 (2), 45 - 52 (2015), DOI: 10.1093/protein/gzu055
- Mikael Altun, Thomas Walter, Holger B. Kramer, P Herr, Alexander Iphöfer, Johan Boström, Yael David, Alia Komsany, Nicola Ternette, Ami Navon, David I. Stuart, Jingshan Ren, Benedikt M. Kessler, "The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages", Plos One, 10 (2015), DOI: 10.1371/journal.pone.0115344
- Theis S. Wilbek, Tine Skovgaard, Fiona Sorrell, Stefan Knapp, Jens Berthelsen, Kristian Stromgaard, "Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1", Chembiochem, 16 (1), 59 - 63 (2015), DOI: 10.1002/cbic.201402512
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