Fragment-based screening is now well-established as a powerful approach to early drug ("lead") discovery.
The PepLites is a small library of halogenated peptidomimetics that was designed in parallel to the FragLites to cover a wider range of druggable interactionsin novel proteins. This library is still under evaluation but was highlighted in the mpro crystallographic screen carried out in March 2020 - link of bioRxiv here.
The research was carried out at the CRUK Newcastle Drug Discovery Unit, Newcastle University (Mike Waring and Martin Noble) and the main investigators were Gemma Davidson - synthetic chemistry, Selma Dormen - synthetic chemistry, James Sanderson - synthetic chemistry and Matthew Martin - structural biology insights
SMILES: click to download the PepLites platemap.
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