Fragment-based screening is now well-established as a powerful approach to early drug ("lead") discovery.
From this innovative approach a spin-out company, Pharmenable, was created to design, validate and synthesis lead molecules to accelerate the early Drug discovery stages. This library is a DOS (Diversity Oriented Synthesis) library designed by the Spring group in the University of Cambridge. It relies on two main ideas:
For more information or if you would like to use the Kidd3D library, please contact Pharmenable ahead of the screen, detailing your project and the target involved.
SMILES: click to download the Kidd 3D plate map.
S. L. Kidd et al., Demonstration of the utility of DOS-derived fragement libraries for rapid hit derivatisation in a multidirectional fashion, Chem. Sci. 2020, Edge Article. DOI
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