Fragment Libraries

We routinely use the DSI-Poised library for both academic and industrial users, and can offer some follow-up support for users screening their target with this library.  

We also have several additional fragment libraries available in-house, totalling over 2000 compounds.  All are available in d6-DMSO at 100-500 mM concentrations, whilst some are also offered in ethylene glycol (EG), typically at 100 mM.  Each library is prepared in an ECHO-compatible source plates ready for rapid crystal soaking experiments.

Details of all of our libraries (both live and decommissioned), are available on each libraries relevant sub-pages, including SMILES, contact details and links to any relevant websites and publications, where available.

None of the compounds in our collection are bound by any IP. All compounds in our collection are commercially available from suppliers, or else published; if you wish to have IP assurances, please contact the suppliers in question. The only requirement Diamond places on use of its facilities, through the academic route is that all results are published (covered by the Policy Documents on Diamond's website (here).

If you want to use your own compounds or have your own fragments library, please have look at our requirements (link to dedicated page).

If you wish to use any of the additional libraries, please let your local contact know well in advance that you would want to use them:

• FragLites: Michael Waring and Martin Noble, CRUK, Newcastle University (link to library page).
• Minifrags: Astex (link to library page)
• Peplites: (Michael Waring and Martin Noble, CRUK, Newcastle University (link to library page)
• Cysteine Covalent Library: Nir London, Weizmann Institute, Israel (link to library page)
• York 3D: Peter O'Brien, University of York (link to library page)
• Leeds 3D: Adam Nelson and Steve Marsden, University of Leeds (link to library page)
• Kidd 3D: Dave Spring and Hannah Sore, University of Cambridge and Pharmenable (link to library page)

We have three decommissioned libraries. The have been in solution in plates for a long time and we are not planning on getting fresh stocks.

• Edelris Keymical (library page)
• UK 3D (library page)
• Maybridge (library page)