Fragment-based screening is now well-established as a powerful approach to early drug ("lead") discovery.
The original 60sec data collection strategy was reduced to test a 30sec and 15sec dose via a reduction in the number of images collected. The results revealed consistent PanDDA hit identification and event and z-map quality across all doses. Placement of ligands can be performed with equal confidence at the reduced doses whilst sample throughput is increased.
Click here for more details on the current and ongoing dose optimisation studies for XChem data collection.
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