Fragment-based screening is now well-established as a powerful approach to early drug ("lead") discovery.
PanDDA hit identification and event and z-map quality for crystals at 2Å resolution or better was maintained at lower doses (30sec and 15sec) when compared to the original 60sec data collection strategy. Placement of ligands can be performed with equal confidence at the reduced doses whilst users sample throughput is increased.
Click here for more details on the current and ongoing dose optimisation studies for XChem data collection.
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
Copyright © 2018 Diamond Light Source
Diamond Light Source Ltd
Harwell Science & Innovation Campus