Section 2: 'Beamline Requirements Summary':
Indicates the requested usage for the next allocation period (6 months)
- Left column: Enter the individual projects that will be evaluated
- Right column: Enter how many of these will be selected for full screens (equivalent to Tier 1 and Tier 2 Standard Access projects here for more information)
- Tier 1 equivalent: 1 shift (8 hours): for experiments where a credible strategy is not yet in place for following up any hits, yet feasibility of the screen itself is high, or the science justifies exploratory XChem access to establish feasibility.
- Tier 2 equivalent: 4 shifts (32 hours): for experiments where feasibility is demonstrated and a robust strategy is articulated for progressing hits to potency.
Section 3: 'Science Case':
Use the following headings and sub-headings:
1. BAG description
- BAG overview. Describe the BAG: who are the PIs, why they would form an effective BAG, why the collectively need XCHem access, what are the various track records in small molecule development
- Target selection process. Describe the mechanism and criteria by which projects are selected and prioritised for progression, and you review that these are effective
- Target progression. Describe infrastructure and funding available for progressing targets, including biophysical assay techniques, computational chemistry support and medchem expertise
- XChem expertise. Specify the designated XChem expert(s): what is their general crystallography and specific XChem experience, by what mechanism are they available for the duration of the BAG, and
- Coordination. Describe how the BAG will operate, including any coordination of hit follow-up
2. Science cases
- Add a science case for each project due in next allocation period (6 months) (3-500 words each).
- Provide enough information that, even if the panel does not approve the BAG as a whole, it can still meaningfully evaulate the merit of individual projects.
- Provide a title as header for each project.
- If a new BAG: one report for every XChem project previously performed by all participating PIs (copy-paste from reports already submitted UAS is appropriate)
- If a current BAG: one report for every XChem screen performed in the previous allocation period
- Reports should demonstrate effectiveness of both the experiment, and of hit exploitation. Include experiment statistics, how hits were progressed, potencies achieved, further funding secured, and resulting publications
- IP sensitive information is not required
- Reuse the original title as header for each report
- Each report need only be long enough to communicate the above points to the panel