Fragment-based screening is now well-established as a powerful approach to early drug ("lead") discovery.
Below are the event maps and z-maps for high resolution crystals i.e. crystals that diffract to 2Å or better in an XChem fragment screening experiment. Each row shows the data from one crystal i.e. the same fragment, each column shows the three different doses with the 15sec maps edged in magenta, the 30sec maps edged in blue and the 60sec maps edged in yellow. E
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