Fragment-based screening is now well-established as a powerful approach to early drug ("lead") discovery.
Below are the event maps and z-maps for high resolution crystals i.e. crystals that diffract to 2Å or better in an XChem fragment screening experiment. Each row shows the data from one crystal i.e. the same fragment, each column shows the three different doses with the 15sec maps edged in magenta, the 30sec maps edged in blue and the 60sec maps edged in yellow. E
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
Copyright © 2020 Diamond Light Source
Diamond Light Source Ltd
Harwell Science & Innovation Campus
Diamond Light Source® and the Diamond logo are registered trademarks of Diamond Light Source Ltd
Registered in England and Wales at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom. Company number: 4375679. VAT number: 287 461 957. Economic Operators Registration and Identification (EORI) number: GB287461957003.