Imaging and Microscopy
Paul Quinn is the Imaging and Microscopy Science Group Leader, and former Principal Beamline Scientist for I14. Paul joined Diamond in 2006 after working at the University of Warwick.
Email: paul.quinn@diamond.ac.ukTel: +44 1235 778583
Paul Quinn
Tel: +44 1235 778583
Current Research Interests
X-ray microscopy, instrumentation and method development, studies of trace metals in biological samples.
Hard x-ray nanoprobes are currently being built around the world to provide high spatial resolution x-ray microscopy. These tools will allow us to probe structural and chemical variations in a wide range samples with a 50 nm or smaller probe. This is an emerging field and a new tool for the science community and our aim is to deliver a instrumentation, sample preparation and data analysis tools which open this tool to the broadest community and best scientific problems.
Using I18, the microfocus spectroscopy beamline, we've studied the affect of metal nanoparticule debris from metal on metal hips on tissue surrounding the hip. We identfied metal species in the tissue and they are co-located with particular cell types but we didn't had the spatial resolution to clearly resolve how individual cells take up the metal. I14 will be able to address this issue by providing a high resolution probe (50nm) capable of probing a range of materials in fine detail.
I am also interested in algorithm development for fast XRF data processing and XRF tomography.
Correlating Metal Poisoning with Zeolite Deactivation in an Individual Catalyst Particle by Chemical and Phase-Sensitive X-ray Microscopy"
Javier Ruiz-Martínez , Andrew M. Beale , Upakul Deka , Mathew G. O'Brien , Paul Quinn , Fred Mosselmans , Bert M. Weckhuysen Angewandte Chemie InternationalEdition DOI: 10.1002/anie.201210030
"Real time observation of x-ray induced surface modification using simultaneous XANES and XEOL-XANES"
Annemie Adriaens , Sergei Nikitenko , Mark Dowsett , Paul Quinn Analytical Chemistry DOI: 10.1021/ac401646q
"Cobalt from metal-on-metal hip replacements maybe the clinically relevant active agent responsible for periprosthetic tissue reactions"
Alister J Hart , Paul D Quinn , Ferdinand Lali , Barry Sampson , John A Skinner , Jonathan J Powell , John Nolan , Keith Tucker , Simon Donell , Adrienne Flanagan , J Fred W Mosselmans Acta Biomaterialia DOI: 10.1016/j.actbio.2012.05.003
