Matt Byrne


Matt is an Electron Microscope Scientist, and joined the electron Bio-Imaging Centre (eBIC) in August 2021.

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Dr Matt Byrne obtained his PhD from the University of Bristol (2016) where he undertook studies in the laboratory of Professor Paul Race, using protein x-ray crystallography to structurally and mechanistically characterise enzymes involved in natural product biosynthesis.

In 2016 Matt began postdoctoral studies at the Astbury Centre for Structural Molecular Biology (Leeds), where he used x-ray crystallography to study human kinase enzymes implicated in cancers, and later used cryo-EM to study virus capsid structures and insecticidal toxins. Following his postdoctoral studies, Matt joined eBIC in August 2021.

Byrne MJ, Iadanza MG, Perez MA, et al. Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane. Nat Commun. 2021. doi:10.1038/s41467-021-23146-4.

Thuenemann, E.C.; Byrne, M.J.; Peyret, H.; Saunders, K.; Castells-Graells, R.; Ferriol, I.; Santoni, M.; Steele, J.F.C.; Ranson, N.A.; Avesani, L.; Lopez-Moya, J.J.; Lomonossoff, G.P. A Replicating Viral Vector Greatly Enhances Accumulation of Helical Virus-Like Particles in Plants. Viruses 2021, 13, 885.

Byrne MJ, Nasir N, Basmadjian C, et al. Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine. Biochem J. 2020. doi:10.1042/BCJ20200128.

Nair A V, Robson A, Ackrill TD, et al. Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation. Sci Rep. 2020;10(1):15323. doi:10.1038/s41598-020-71850-w.

Byrne MJ, Steele JFC, Hesketh EL, et al. Combining Transient Expression and Cryo-EM to Obtain High-Resolution Structures of Luteovirid Particles. Structure. 2019. doi:10.1016/j.str.2019.09.010.

Marsh CO, Lees NR, Han LC, et al. A Natural Diels-Alder Biocatalyst Enables Efficient [4+2] Cycloaddition Under Harsh Reaction Conditions. ChemCatChem. 2019. doi:10.1002/cctc.201901285.

Lees NR, Han LC, Byrne MJ, et al. An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis. Angew Chemie - Int Ed. 2019. doi:10.1002/anie.201812105.

Hesketh EL, Tiede C, Adamson H, et al. Affimer reagents as tools in diagnosing plant virus diseases. Sci Rep. 2019. doi:10.1038/s41598-019-43945-6.

Byrne MJ, Lees NR, Han LC, et al. The Catalytic Mechanism of a Natural Diels-Alderase Revealed in Molecular Detail. J Am Chem Soc. 2016. doi:10.1021/jacs.6b00232.

Till M, Robson A, Byrne MJ, et al. Improving the success rate of protein crystallization by random microseed matrix screening. J Vis Exp. 2013. doi:10.3791/50548.

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