Julika Radecke


Julika is a Senior Electron Microscope Scientist at the electron Bio-Imaging Centre (eBIC). She joined Diamond in March 2019 after a postdoc in neuroscience at Copenhagen University.

Email: julika.radecke@diamond.ac.uk
Tel: +44 (0) 1235 77 8931

Techniques and Disciplines

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After completing her Master in Biology at Rostock University, Julika Radecke, moved to Bern where she obtained her Ph.D. in Neurobiology under the supervision of Benoit Zuber. She studied the morphological changes of synaptic vesicle exocytosis by time-resolved cryo-electron tomography (cryo-ET). Furthermore, in collaboration she investigated the ultrastructure of the pore forming toxin pneumolysin.

For her postdoc in Copenhagen with Jakob Sørensen she obtained an early postdoc mobility fellowship from the Swiss National Science Foundation to study the effects of SNARE mutations on cultured primary neurons by cryo-ET.

Following her postdoc she moved to the UK, where she started working as Senior Support Scientist for Cryo-Electron Microscopy at the Electron Bio-Imaging Centre (eBIC) at Diamond Light Source, and was promoted to Electron Microscope Scientist in August 2020.

Mendonça L, Howe A, Gilchrist JB, Sun D, Knight ML, Zanetti-Domingues LC, Bateman B, Krebs AS, Chen L, Radecke J, Sheng Y, Li VD, Ni T, Kounatidis I, Koronfel MA, Szynkiewicz M, Harkiolaki M, Martin-Fernandez ML, James W, Zhang P. Correlative Multi-scale imaging Unveils SARS-CoV-2 Assembly and Egress. Nat Comms 2021. Accepted.

Dejnirattisai, W., Zhou, D., Ginn, H. M., Duyvesteyn, H. M. E., Supasa, P., Case, J. B., Zhao, Y., Walter, T. S., Mentzer, A. J., Liu, C., Wang, B., Paesen, G. C., Slon-Campos, J., López-Camacho, C., Kafai, N. M., Bailey, A. L., Chen, R. E., Ying, B., Thompson, C., …, Radecke J, … Screaton, G. R. (2021). The antigenic anatomy of SARS-CoV-2 receptor binding domain. Cell, 184(8), 2183-2200.

Huo J, Le Bas A, Ruza RR, Duyvesteyn HME, Mikolajek H, Malinauskas T, Tan TK, Rijal P, Dumoux M, Ward PN, Ren J, Zhou D, Harrison PJ, Weckener M, Clare DK, Vogirala VK, Radecke J, Moynié L, Zhao Y, Gilbert-Jaramillo J, Knight ML, Tree JA, Buttigieg KR, Coombes N, Elmore MJ, Carroll MW, Carrique L, Shah PNM, James W, Townsend AR, Stuart DI, Owens RJ, Naismith JH (2020). Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2. Nature Structural & Molecular Biology, 27 (9), 846-854.

Zhou D, Duyvesteyn HME, Chen CP, Huang CG, Chen TH, Shih SR, Lin YC, Cheng CY, Cheng SH, Huang YC, Lin TY, Ma C, Huo J, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Donat RF, Godwin K, Buttigieg KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll MW, Gilbert-Jaramillo J, Knight ML, James W, Owens RJ, Naismith JH, Townsend AR, Fry EE, Zhao Y, Ren J, Stuart DI, Huang KA (2020). Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient. Nature Structural & Molecular Biology, 27 (10), 950-958.

Huo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI (2020). Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike. Cell Host & Microbe, 28 (3), 445-454.

Radecke J*, Kádková A*, and Sørensen JB (2019). The SNAP-25 protein family. *Shared First-Author. Neuroscience, 420, 50-71.

Adolfo Odriozola, Jaime Llodrá, Julika Radecke, Céline Ruegsegger, Stefan Tschanz, Smita Saxena, Stephan Rohr, Benoît Zuber. High contrast staining for serial block face scanning electron microscopy without uranyl acetate. bioXriv 2017.

Radecke J*, Wolfmeier H*, Schoenauer R, Koeffel R, Babiychuk VS, Druecker P, Hathaway LJ, Mitchell T, Zuber B, Draeger A and Babiychuk EB (2016). Active release of pneumolysin prepores and pores by mammalian cells undergoing a Streptococcus pneumoniae attack. Biochimica et Biophysica Acta, 1860, 2498-2509. * Shared First-Author.

Stucki DM, Ruegsegger C, Steiner S, Radecke J, Murphy MP, Zuber B and Saxena S (2016). Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ. Free Radical Biology and Medicine, 97, 427-440.

Ruegsegger C, Stucki DM, Steiner S, Angliker N, Radecke J, Keller E, Zuber B, Ruegg MA and Saxena S (2016). Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. Neuron, 89 (1), 129-146.

Di Benedetto B, Radecke J, Schmidt MVV & Rupprecht R (2013). Acute antidepressant treatment differently modulates ERK/MAPK activation in neurons and astrocytes of the adult mouse prefrontal cortex. Neuroscience, 232, 161–168.

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