Applications for Rapid Access should be made in the UAS.
Please note that the standard allocation period for Rapid Access is 2 days and we award one proposal per project. An individual PI will be awarded at most 3 Rapid sessions per 6 month allocation period.
Rapid proposals are welcome at any time. If you are based outside the UK in Europe please apply via iNEXT.
Please note that the main route of access to eBIC is via the Group (BAG) Access route. So please follow this route of access if at all possible.
iNEXT will peer review the scientific merit of your application, but iNEXT will send it to eBIC for technical assessment. It is therefore essential that you follow Diamond acceptance criteria, which is to provide images of 2D classes calculated from the cryoEM sample under investigation. In most cases your 2D classes should be able to produce a map of high enough resolution to show secondary structure. This criteria is designed to ensure that projects are well progressed and investigators bring high quality grids, with good ice and optimised conditions for the sample under investigation.
Please also be aware that the standard allocation period for Rapid Access is 2 days and we award one proposal per project. An individual PI will be awarded at most 3 Rapid sessions per 6 month allocation period.
Applications should be made through the Diamond User Administration System (UAS). The BAG access route provides a mechanism for a group of users to generate a critical mass of projects to allow flexible and frequent access to eBIC over a 2 year period. Full details of the BAG system can be found here.
Once a BAG proposal commences, access for time through the Rapid access route is no longer valid. However, until your BAG commences you can still apply through the Rapid route. BAG access is the main route for microscope time at eBIC with Rapids reserved for urgent access to eBIC.
Once your BAG proposal commences all eBIC microscope time will be allocated to the BAG and requests for more or less time should be made through the BAG process and can be made bi-annually coinciding with proposal deadline dates.
We expect to allocate over 300 days of microscope time to the peer reviewed user programme during Oct 2018 – Mar 2019 of which up to 80% may be allocated to BAGS.
If you are considering a BAG application please contact the eBIC team (EBICadmin@diamond.ac.uk) ahead of the deadline, to discuss informally your requirements.
On the initial submission of a new proposal the user must supply the following details:
- People who will be attached to the proposal.
- A Principal Investigator (PI) who is responsible for the proposal and the efficient organisation of the time on the microscope.
- An Alternate Contact (AC) may be nominated by the PI to have permission to act on their behalf. Often this is the person who will be responsible for organising the visits to Diamond. Mulltiple ACs can be nominated.
- Details of the projects which are to be studied.
- Sample information for these projects must also be specified on the proposal.
- Amount of time required for the following 6 months.
Applications should be made via the UAS and users should request the eBIC - Cryo-Electron Microscopy for Life Sciences. If awarded time then the proposal will be scheduled with one of the eBIC Krios microscopes or where required the Polara microscope at OPIC.
If the BAG is awarded time then the user must provide the following information every 6 months:
- A report on the work which has been undertaken to date
- The time required for the following 6 months
- Further projects and samples could also be included at this stage as well as additional people.
Important: Users awarded a BAG will not be awarded additional time through the rapid access route.
- BAG access is the main access route for eBIC.
- BAGs consist of groups of users who apply jointly for time spread over a period of two years at a time.
- BAGs usually consist of a number of researchers from the same research institute or of researchers from smaller institutes in the same region of the UK.
- Once your BAG commences you can no longer apply for microscope time through the rapid access route.
- If you wish to join a BAG, form a new BAG, or have any further questions please contact the eBIC team(EBICadmin@diamond.ac.uk).
All proposals are awarded time based on scientific excellence and are subject to standard Diamond terms and conditions, notably that the work must be published.
It is eBIC's remit to provide a high resolution data collection service for projects that have already been developed in a users own facility. We do not offer a grid screening or project development service for academic users. This is only available for industrial/commercial clients who should contact the industrial liaison group.
Academic proposals must include images and evidence that suitable cryoEM samples have already been produced.
For the review process you must provide images of 2D classes calculated from the cryoEM sample under investigation. In most cases these 2D classes should be of high enough resolution to calculate a map that demonstrates secondary structure.
This criteria is designed to ensure that projects are well progressed and investigators bring high quality grids, with good ice and optimised conditions for the sample under investigation.
Travel and Subsistence
Accommodation, travel and subsistence is covered for UK users (normally 1-2 people per visit with a maximum of 3 people per visit).
If you are travelling to eBIC from the EU, please be aware that iNEXT will pay for flights for up to 3 people, or 2 people and a dewar. Your accommodation and subsistence will also be covered.
Diamond does not cover travel, accomodation or subsistence for users from outside the UK and EU, although it will assist with making bookings for your accomodation.
Accommodation is at the on-site guest house or nearby.