Chidinma Okolo

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Chidinma is a Support Scientist at beamline B24. Chidinma joined Diamond in 2019 after completing her PhD thesis at University of Otago, New Zealand.

Email: chidinma.okolo@diamond.ac.uk
Tel: +44 (0) 1235778662
  •  Structural Biology
  • General and Cardiovascular Physiology
  • Post-translational Modifications
  • Metabolic Syndrome and Therapeutic Approaches
  • Fish Pathology
  • Parasite Physiology
  • Zoology
  •  E U Asamudo and C A Okolo, Book Review: ”The Prevention of Cardiovascular Disease Through the Mediterranean Diet”. Frontiers in Physiology. Volume 10(52). February 2019. DOI: 10.3389/fphys.2019.00052.
  • C A Okolo and E U Asamudo. Book Review: Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and Their Interaction in Frontiers in Physiology. Volume 9(1570), Nov 2018. DOI: 10.3389/fphys.2018.01570.
  • J.Z Zhang, H.M.M Waddell, E.Wu, J. Dholakia, C.A Okolo, J.C McLay and P.P Jones, ”FKBPs facilitate the termination of spontaneous Ca2+ release in wild type RyR2 but not CPVT mutant RyR2”. Biochemical Journal. Volume 473 (July 2016), Pages 2049 2060. DOI: 10.1042/BCJ20160389.
  • Okolo, C A, Ejere, V C, Chukwuka, O C, Ezeigbo, I I, Nwibo, D D, Okorie, A N. ”Hexane Extract of Dacryodes edulis Fruits Possesses Antidiabetic and Hypolipidaemic Potentials in Alloxan Diabetes of Rats ”. African Journal of Traditional Alternative and Complementary Medicine (AJTCAM), Volume 13(4) (2016), pp 132 - 144. DOI: 10.21010/ajtcam.v13i4.18.
  • D D Nwibo, C A Levi and M I Nwibo, ”Small Molecule Drugs; Down but Not Out: A Future for Medical Research and Therapeutics”. IOSR Journal of Dental and Medical Sciences. Volume 14(1), Version I (January 2015), pp 70 - 77. 6.
  • C O Chukwuka, V C Ejere, C N Asogwa, E I Nnamonu, O C Okeke, E C Odii, G C Ugwu, L C Okanya and C A Levi, ”Eco-physiological adaptation of land snail Achatina achatina (Gastropoda: Pulmonata) in tropical agro ecosystem”. Journal of Basic and Applied Zoology, Volume 67(2) (March 2014), pp 48 - 57 DOI: 10.1016/j.jobaz.2014.06.001.
  • J E Eyo, C A Levi, C N Asogwa, E C Odii, C O Chukwuka, N I, U S Onoja and C C Onyeke. , Toxicity and effect of Carica papaya seed aqueous extract on Liver biomarkers of Clarias gariepinus in Recent Science. International Journal of indigenous medicinal plant, Asia, Volume 46(3) (August 2013), pp 1301 1307.

Research Summary

  1. Biography and Research
  2. Publications
  3. Education
  4. Awards and Grants
  5. Collaborations
Biography and Research -

Chidinma graduated from the University of Nigeria, Nsukka with a Bachelor of Science degree in Zoology (2011) and a Master of Science degree in Zoology (with specialization in Physiology) (2015). She worked for 3 years as an Assistant Lecturer at the University of Nigeria, Nsukka, before proceeding to New Zealand for her Doctoral training. She completed her Doctoral training from the University of Otago, New Zealand and was awarded the degree in December 2019. Her thesis expanded existing knowledge on the implication of post-translational modifications on the diabetic heart, with focus on the cardiac ryanodine receptor.

During her Doctoral training, she used a variety of super-resolution imaging techniques (Direct stochastic optical reconstruction microscopy (dSTORM), confocal microscopy and Expansion microscopy (ExM)) to study the cardiac ultrastructure, morphology and spatial distribution of cardiac proteins in response to acute and chronic triggers. With a grasp on the world of microscopy and the quest to achieve super-resolved images, Chidinma found herself highly interested in the organisation of cellular ultrastructure in response to biological or external cues. 

This led her to pick up a role at Beamline 24 in Diamond, where she continues to study structural changes in cellular organelles, viruses, parasites and cardiac proteins with time, in response to different stimulus using correlative light and X-ray microscopy. Her primary role is to use her array of knowledge, technical skills and soft skills to provide user support to academic and industrial users at the Beamline.

 

Publications - +
  • E U Asamudo and C A Okolo, Book Review: ”The Prevention of Cardiovascular Disease Through the Mediterranean Diet”. Frontiers in Physiology. Volume 10(52). February 2019. DOI: 10.3389/fphys.2019.00052.
  • C A Okolo and E U Asamudo. Book Review: Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and Their Interaction in Frontiers in Physiology. Volume 9(1570), Nov 2018. DOI: 10.3389/fphys.2018.01570.
  • J.Z Zhang, H.M.M Waddell, E.Wu, J. Dholakia, C.A Okolo, J.C McLay and P.P Jones, ”FKBPs facilitate the termination of spontaneous Ca2+ release in wild type RyR2 but not CPVT mutant RyR2”. Biochemical Journal. Volume 473 (July 2016), Pages 2049 2060. DOI: 10.1042/BCJ20160389.
  • Okolo, C A, Ejere, V C, Chukwuka, O C, Ezeigbo, I I, Nwibo, D D, Okorie, A N. ”Hexane Extract of Dacryodes edulis Fruits Possesses Antidiabetic and Hypolipidaemic Potentials in Alloxan Diabetes of Rats ”. African Journal of Traditional Alternative and Complementary Medicine (AJTCAM), Volume 13(4) (2016), pp 132 - 144. DOI: 10.21010/ajtcam.v13i4.18.
  • D D Nwibo, C A Levi and M I Nwibo, ”Small Molecule Drugs; Down but Not Out: A Future for Medical Research and Therapeutics”. IOSR Journal of Dental and Medical Sciences. Volume 14(1), Version I (January 2015), pp 70 - 77. 6.
  • C O Chukwuka, V C Ejere, C N Asogwa, E I Nnamonu, O C Okeke, E C Odii, G C Ugwu, L C Okanya and C A Levi, ”Eco-physiological adaptation of land snail Achatina achatina (Gastropoda: Pulmonata) in tropical agro ecosystem”. Journal of Basic and Applied Zoology, Volume 67(2) (March 2014), pp 48 - 57 DOI: 10.1016/j.jobaz.2014.06.001.
  • J E Eyo, C A Levi, C N Asogwa, E C Odii, C O Chukwuka, N I, U S Onoja and C C Onyeke. , Toxicity and effect of Carica papaya seed aqueous extract on Liver biomarkers of Clarias gariepinus in Recent Science. International Journal of indigenous medicinal plant, Asia, Volume 46(3) (August 2013), pp 1301 1307.
 

 

Education - +
  • Doctor of Philosopy (PhD) in Physiology, University of Otago, Dunedin, New Zealand (2015 - 2019).

 

  • Master of Science in Zoology and Environmental Biology with specialisation in Physiology (Distinction; 5.0/5.0 cGPA), University of Nigeria, Nsukka, Nigeria (2014 – 2015).

 

  • Bachelor of Science in Zoology (First Class Honours; 4.75/5.0 cGPA), University of Nigeria, Nsukka, Nigeria (2007 - 2011).
 

 

Awards and Grants - +
  • Best Oral Communication Prize. Sponsored by eLIFE and jointly awarded by The Physiological Society, UK; Biochemical Society, UK and British Pharmacological Society (March 2019).
  • The Physiological Society, UK Travel Grant (December 2018).
  • Maurice and Phyllis Paykel Trust (MPPT) Conference Funding. Funding awarded for The Physiological Society, Biochemical Society and British Pharmacological Society joint satellite meeting titled; Life Sciences 2019: Post-translational modifications and cell signalling, in Nottingham, UK (October 2018).
  • Department of Physiology, University of Otago, Dunedin, New Zealand, Conference Travel Award. Funding awarded for The Physiological Society, Biochemical Society and British Pharmacological Society joint satellite meeting titled; Life Sciences 2019: Post-translational modifications and cell signalling, in Nottingham, UK (October 2018).
  • Division of Health Sciences, University of Otago, Dunedin, New Zealand, Conference Travel Grant (October 2018).
  • Queenstown Molecular Biology (QMB) Childcare Funding. Sponsored by QMB and New Zealand Medical Sciences (MedSci). Childcare funding to cater for childcare needs arising from travel during Queenstown research week (New Zealand Medical Sciences Congress Meeting) (August 2018).
  • Doctoral Scholarship, awarded by the University of Otago Doctoral Office. Full tuition plus stipends for 3 years (June 2015).
  • Doctoral Scholarship, awarded by the Department of Physiology, University of Otago. Full tuition plus stipends for 3 years (April 2015, forfeited).
  • Masters Scholarship Award for Staff. Full tuition waiver awarded by the University of Nigeria, Nsukka (January 2014).
  • Best Graduating Student in Department of Zoology. Award bestowed at the convocation ceremony of the University of Nigeria, Nsukka (January 2012).
  • Best Graduating Student in the Faculty of Biological Sciences. Award bestowed at the convocation ceremony of the University of Nigeria, Nsukka (January 2012).
  • Exxon Mobil Undergraduate Scholarship Award. Scholarship awarded by Exxon Mobil/NNPC for three years Scholarship towards full tuition rebate and research project (September 2009).
  • 3rd Best in WASSCE (GSCE equivalent) (FGGC Owerri) 2007 set. Award issued by Federal Government Girls' College Owerri for finishing with 7A1's, 1B2 & 1B3 (October 2007).

 

Collaborations - +
  • I have strong ties with my alma maters in Nigeria and New Zealand and have continued to forge research collaborations with my mentors, colleagues and previous supervisors.

Image result for university of nigeria nsukka"Image result for physiology department university of oatgo"

  •  We have recently established collaborative research with Prof Venugopal from Pirbright Institute.

Image result for pirbright

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